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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2011 Volume 26 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2011 Volume 26 Issue 5

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Article

Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines

  • Authors:
    • Mitsuhiro Masuda
    • Manami Shimomura
    • Ken Kobayashi
    • Shuji Kojima
    • Tetsuya Nakatsura
  • View Affiliations / Copyright

    Affiliations: Section for Cancer Immunotherapy, Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan, Section for Cancer Immunotherapy, Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan
  • Pages: 1273-1279
    |
    Published online on: July 1, 2011
       https://doi.org/10.3892/or.2011.1370
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Abstract

Dysregulation of the phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway frequently occurs in human tumors, and is therefore considered to be a good molecular target for treatment. In hepatocellular carcinoma (HCC), overexpression of p-Akt and decrease of PTEN expression have been reported. NVP-BEZ235 is a novel dual inhibitor of PI3K and mTOR; however, its effect on HCC has not been documented. Consequently, we investigated the effects of NVP-BEZ235 on the PLC/PRF/5, HLE, JHH7 and HepG2 HCC cell lines in vitro and in vivo. NVP-BEZ235 decreased the levels of p-Akt and p-p70S6K and inhibited cell proliferation in all HCC cell lines in a dose-dependent manner. Flow cytometric analysis revealed that inhibition of cell proliferation by NVP-BEZ235 was accompanied by G1 arrest in all cell lines, and that NVP-BEZ235 induced apoptosis in PLC/PRF/5 and HLE cells. Tumor growth was suppressed without body weight loss when NVP-BEZ235 was orally administered to JHH-7 tumor-bearing mice for 11 days. These results suggest that NVP-BEZ235 is a potential new candidate for targeted HCC therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Masuda M, Shimomura M, Kobayashi K, Kojima S and Nakatsura T: Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines. Oncol Rep 26: 1273-1279, 2011.
APA
Masuda, M., Shimomura, M., Kobayashi, K., Kojima, S., & Nakatsura, T. (2011). Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines. Oncology Reports, 26, 1273-1279. https://doi.org/10.3892/or.2011.1370
MLA
Masuda, M., Shimomura, M., Kobayashi, K., Kojima, S., Nakatsura, T."Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines". Oncology Reports 26.5 (2011): 1273-1279.
Chicago
Masuda, M., Shimomura, M., Kobayashi, K., Kojima, S., Nakatsura, T."Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines". Oncology Reports 26, no. 5 (2011): 1273-1279. https://doi.org/10.3892/or.2011.1370
Copy and paste a formatted citation
x
Spandidos Publications style
Masuda M, Shimomura M, Kobayashi K, Kojima S and Nakatsura T: Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines. Oncol Rep 26: 1273-1279, 2011.
APA
Masuda, M., Shimomura, M., Kobayashi, K., Kojima, S., & Nakatsura, T. (2011). Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines. Oncology Reports, 26, 1273-1279. https://doi.org/10.3892/or.2011.1370
MLA
Masuda, M., Shimomura, M., Kobayashi, K., Kojima, S., Nakatsura, T."Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines". Oncology Reports 26.5 (2011): 1273-1279.
Chicago
Masuda, M., Shimomura, M., Kobayashi, K., Kojima, S., Nakatsura, T."Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines". Oncology Reports 26, no. 5 (2011): 1273-1279. https://doi.org/10.3892/or.2011.1370
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