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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2011 Volume 26 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

IDH mutations occur frequently in Chinese glioma patients and predict longer survival but not response to concomitant chemoradiotherapy in anaplastic gliomas

  • Authors:
    • Song-Τao Qi
    • Lei Yu
    • Yun-Tao Lu
    • Yang-Hui Ou
    • Zhi-Yong Li
    • Lan-Xiao Wu
    • Fei Yao

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R. China, Helixgen (Guangzhou) Biotech Co. Ltd., Guangzhou 510663, P.R. China
  • Pages: 1479-1485
    |
    Published online on: August 19, 2011
       https://doi.org/10.3892/or.2011.1428
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Abstract

Mutations in the isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) appear to occur frequently and selectively in gliomas. Our aim was to assess whether IDH mutations are common in Chinese glioma patients and whether the mutations predict good response to concomitant chemoradiotherapy. In this study IDH1 and IDH2 mutations were detected in a series of 203 gliomas. IDH1 mutations were present in 75 of the 203 cases (36.9%) while IDH2 mutations in 5 of the 203 cases (2.5%). No tumor was mutated in both IDH1 and IDH2. IDH1/2 mutations were associated with prolonged overall survival in the whole series of patients exclusive of pilocytic astrocytoma (P<0.001), WHO grade Ⅱ patients who received no adjuvant therapy after surgery (P=0.014) and WHO grade Ⅲ patients who received concomitant chemoradiotherapy (standard schedule) after surgery (P=0.033). Furthermore, there was no correlation between IDH1/2 mutations and reponse to concomitant chemoradiotherapy in anaplastic gliomas. Our results suggest that IDH1 mutations also occur freuqently in Chinese glioma patients but the frequency of IDH1 mutations is below the findings reported by North American and European groups. Furthermore, we confirm the prognostic significance of IDH1/2 mutations in gliomas, but the mutations cannot predict a favorable response to concomitant chemoradiotherapy in anaplastic gliomas.

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Copy and paste a formatted citation
Spandidos Publications style
Qi S, Yu L, Lu Y, Ou Y, Li Z, Wu L and Yao F: IDH mutations occur frequently in Chinese glioma patients and predict longer survival but not response to concomitant chemoradiotherapy in anaplastic gliomas. Oncol Rep 26: 1479-1485, 2011.
APA
Qi, S., Yu, L., Lu, Y., Ou, Y., Li, Z., Wu, L., & Yao, F. (2011). IDH mutations occur frequently in Chinese glioma patients and predict longer survival but not response to concomitant chemoradiotherapy in anaplastic gliomas. Oncology Reports, 26, 1479-1485. https://doi.org/10.3892/or.2011.1428
MLA
Qi, S., Yu, L., Lu, Y., Ou, Y., Li, Z., Wu, L., Yao, F."IDH mutations occur frequently in Chinese glioma patients and predict longer survival but not response to concomitant chemoradiotherapy in anaplastic gliomas". Oncology Reports 26.6 (2011): 1479-1485.
Chicago
Qi, S., Yu, L., Lu, Y., Ou, Y., Li, Z., Wu, L., Yao, F."IDH mutations occur frequently in Chinese glioma patients and predict longer survival but not response to concomitant chemoradiotherapy in anaplastic gliomas". Oncology Reports 26, no. 6 (2011): 1479-1485. https://doi.org/10.3892/or.2011.1428
Copy and paste a formatted citation
x
Spandidos Publications style
Qi S, Yu L, Lu Y, Ou Y, Li Z, Wu L and Yao F: IDH mutations occur frequently in Chinese glioma patients and predict longer survival but not response to concomitant chemoradiotherapy in anaplastic gliomas. Oncol Rep 26: 1479-1485, 2011.
APA
Qi, S., Yu, L., Lu, Y., Ou, Y., Li, Z., Wu, L., & Yao, F. (2011). IDH mutations occur frequently in Chinese glioma patients and predict longer survival but not response to concomitant chemoradiotherapy in anaplastic gliomas. Oncology Reports, 26, 1479-1485. https://doi.org/10.3892/or.2011.1428
MLA
Qi, S., Yu, L., Lu, Y., Ou, Y., Li, Z., Wu, L., Yao, F."IDH mutations occur frequently in Chinese glioma patients and predict longer survival but not response to concomitant chemoradiotherapy in anaplastic gliomas". Oncology Reports 26.6 (2011): 1479-1485.
Chicago
Qi, S., Yu, L., Lu, Y., Ou, Y., Li, Z., Wu, L., Yao, F."IDH mutations occur frequently in Chinese glioma patients and predict longer survival but not response to concomitant chemoradiotherapy in anaplastic gliomas". Oncology Reports 26, no. 6 (2011): 1479-1485. https://doi.org/10.3892/or.2011.1428
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