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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2011 Volume 26 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3

  • Authors:
    • Yukio Fujiwara
    • Yoshihiro Komohara
    • Rino Kudo
    • Keiichiro Tsurushima
    • Koji Ohnishi
    • Tsuyoshi Ikeda
    • Motohiro Takeya

  • View Affiliations / Copyright

    Affiliations: Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Honjo 1-1-1, Kumamoto 860-8556, Japan
  • Pages: 1533-1537
    |
    Published online on: September 12, 2011
       https://doi.org/10.3892/or.2011.1454
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Abstract

Tumor-associated macrophages (TAMs) polarized to the M2 phenotype promote tumor cell proliferation and are associated with a poor prognosis in patients with high grade glioma. We previously revealed that corosolic acid, a triterpenoid compound, inhibits the M2 polarization of human monocyte-derived macrophages (HMDM). In the present study, we examined whether oleanolic acid (OA), a triterpenoid compound whose structure is similar to corosolic acid, also shows inhibitory effects on M2 polarization in HMDM. OA significantly inhibited the expression of CD163, one of the phenotype markers of M2 macrophages, as well as suppressed the secretion of IL-10, one of the anti-inflammatory cytokines preferentially produced by M2 macrophages, thus suggesting that OA suppresses the M2 polarization of macrophages. Furthermore, OA inhibited the proliferation of U373 human glioblastoma cells, and the activation of signal transducer and activator of transcription-3 (STAT3) in both human macrophages and glioblastoma cells. These results indicate that OA suppresses the M2 polarization of macrophages and tumor cell proliferation by inhibiting STAT3 activation. Therefore, OA may be a potentially new agent that can be used for the prevention and treatment of various malignant tumors, including glioma.

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Copy and paste a formatted citation
Spandidos Publications style
Fujiwara Y, Komohara Y, Kudo R, Tsurushima K, Ohnishi K, Ikeda T and Takeya M: Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3. Oncol Rep 26: 1533-1537, 2011.
APA
Fujiwara, Y., Komohara, Y., Kudo, R., Tsurushima, K., Ohnishi, K., Ikeda, T., & Takeya, M. (2011). Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3. Oncology Reports, 26, 1533-1537. https://doi.org/10.3892/or.2011.1454
MLA
Fujiwara, Y., Komohara, Y., Kudo, R., Tsurushima, K., Ohnishi, K., Ikeda, T., Takeya, M."Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3". Oncology Reports 26.6 (2011): 1533-1537.
Chicago
Fujiwara, Y., Komohara, Y., Kudo, R., Tsurushima, K., Ohnishi, K., Ikeda, T., Takeya, M."Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3". Oncology Reports 26, no. 6 (2011): 1533-1537. https://doi.org/10.3892/or.2011.1454
Copy and paste a formatted citation
x
Spandidos Publications style
Fujiwara Y, Komohara Y, Kudo R, Tsurushima K, Ohnishi K, Ikeda T and Takeya M: Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3. Oncol Rep 26: 1533-1537, 2011.
APA
Fujiwara, Y., Komohara, Y., Kudo, R., Tsurushima, K., Ohnishi, K., Ikeda, T., & Takeya, M. (2011). Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3. Oncology Reports, 26, 1533-1537. https://doi.org/10.3892/or.2011.1454
MLA
Fujiwara, Y., Komohara, Y., Kudo, R., Tsurushima, K., Ohnishi, K., Ikeda, T., Takeya, M."Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3". Oncology Reports 26.6 (2011): 1533-1537.
Chicago
Fujiwara, Y., Komohara, Y., Kudo, R., Tsurushima, K., Ohnishi, K., Ikeda, T., Takeya, M."Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3". Oncology Reports 26, no. 6 (2011): 1533-1537. https://doi.org/10.3892/or.2011.1454
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