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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2012 Volume 27 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells

  • Authors:
    • Zeyad D. Nassar
    • Abdalrahim F.A. Aisha
    • Norshirin Idris
    • Mohamed B. Khadeer Ahamed
    • Zhari Ismail
    • Khalid M. Abu-Salah
    • Salman A. Alrokayan
    • Amin Malik Shah Abdul Majid

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, Pulau Penang, Malaysia
  • Pages: 727-733
    |
    Published online on: November 30, 2011
       https://doi.org/10.3892/or.2011.1569
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Abstract

Deregulated cell signaling pathways result in cancer development. More than one signal transduction pathway is involved in colorectal cancer pathogenesis and progression. Koetjapic acid (KA) is a naturally occurring seco-A-ring oleanene triterpene isolated from the Sandoricum koetjape stem bark. We report the cellular and molecular mechanisms of anticancer activity of KA towards human colorectal cancer. The results showed that KA induces apoptosis in HCT 116 colorectal carcinoma cells by inducing the activation of extrinsic and intrinsic caspases. We confirmed that KA-induced apoptosis was mediated by DNA fragmentation, nuclear condensation and disruption in the mitochondrial membrane potential. Further studies on the effect of KA on cancer pathways show that the compound causes down-regulation of Wnt, HIF-1α, MAP/ERK/JNK and Myc/Max signaling pathways and up-regulates the NF-κB signaling pathway. The result of this study highlights the anticancer potential of KA against colorectal cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Nassar ZD, Aisha AF, Idris N, Khadeer Ahamed MB, Ismail Z, Abu-Salah KM, Alrokayan SA and Abdul Majid AM: Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells. Oncol Rep 27: 727-733, 2012.
APA
Nassar, Z.D., Aisha, A.F., Idris, N., Khadeer Ahamed, M.B., Ismail, Z., Abu-Salah, K.M. ... Abdul Majid, A.M. (2012). Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells. Oncology Reports, 27, 727-733. https://doi.org/10.3892/or.2011.1569
MLA
Nassar, Z. D., Aisha, A. F., Idris, N., Khadeer Ahamed, M. B., Ismail, Z., Abu-Salah, K. M., Alrokayan, S. A., Abdul Majid, A. M."Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells". Oncology Reports 27.3 (2012): 727-733.
Chicago
Nassar, Z. D., Aisha, A. F., Idris, N., Khadeer Ahamed, M. B., Ismail, Z., Abu-Salah, K. M., Alrokayan, S. A., Abdul Majid, A. M."Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells". Oncology Reports 27, no. 3 (2012): 727-733. https://doi.org/10.3892/or.2011.1569
Copy and paste a formatted citation
x
Spandidos Publications style
Nassar ZD, Aisha AF, Idris N, Khadeer Ahamed MB, Ismail Z, Abu-Salah KM, Alrokayan SA and Abdul Majid AM: Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells. Oncol Rep 27: 727-733, 2012.
APA
Nassar, Z.D., Aisha, A.F., Idris, N., Khadeer Ahamed, M.B., Ismail, Z., Abu-Salah, K.M. ... Abdul Majid, A.M. (2012). Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells. Oncology Reports, 27, 727-733. https://doi.org/10.3892/or.2011.1569
MLA
Nassar, Z. D., Aisha, A. F., Idris, N., Khadeer Ahamed, M. B., Ismail, Z., Abu-Salah, K. M., Alrokayan, S. A., Abdul Majid, A. M."Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells". Oncology Reports 27.3 (2012): 727-733.
Chicago
Nassar, Z. D., Aisha, A. F., Idris, N., Khadeer Ahamed, M. B., Ismail, Z., Abu-Salah, K. M., Alrokayan, S. A., Abdul Majid, A. M."Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells". Oncology Reports 27, no. 3 (2012): 727-733. https://doi.org/10.3892/or.2011.1569
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