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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2012 Volume 28 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

7,8-dihydroxyflavone induces G1 arrest of the cell cycle in U937 human monocytic leukemia cells via induction of the Cdk inhibitor p27 and downregulation of pRB phosphorylation

  • Authors:
    • Hye Young Park
    • Gi-Young Kim
    • Jin Won Hyun
    • Nam Deuk Kim
    • Chan Gil Kim
    • Wun-Jae Kim
    • Young Hyun Yoo
    • Yung Hyun Choi

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614-714, Republic of Korea , Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea, School of Medicine and Applied Radiological Science Research Institute, Jeju National University, Jeju 690-756, Republic of Korea, Department of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea, Department of Biotechnology, Konkuk University, Chungju 380-701, Republic of Korea, Department of Urology, Chungbuk National University College of Medicine, Cheongju 361-763, Republic of Korea, Department of Anatomy and Cell Biology and Mitochondria Hub Regulation Center, College of Medicine, Dong-A University, Busan 602-714, Republic of Korea
  • Pages: 353-357
    |
    Published online on: April 23, 2012
       https://doi.org/10.3892/or.2012.1773
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Abstract

We investigated the mechanisms of the anti-proliferative action of 7,8-dihydroxyflavone (7,8-DHF), a member of the flavonoid family, in U937 human monocytic leukemia cells. We found that 7,8-DHF time-dependently inhibited the growth of U937 cells, arresting them in the G1 phase of their cell cycle and inducing apoptosis. 7,8-DHF-induced G1 arrest was correlated with downregulation of cyclin E, with a concomitant upregulation of cyclin-dependent kinase (Cdk) inhibitors including p27, and association of p27 with Cdk2 was markedly induced in 7,8-DHF-treated cells. We also observed that downregulation of the phosphorylation of retinoblastoma protein (pRB) by this flavonoid was associated with enhanced binding of pRB and the transcription factor E2F-1. Overall, our results demonstrate a combined mechanism for the anticancer effects of 7,8-DHF that involves the inhibition of pRB phosphorylation and induction of p27 as targets for 7,8-DHF.

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Copy and paste a formatted citation
Spandidos Publications style
Park H, Kim G, Hyun J, Kim N, Kim C, Kim W, Yoo Y and Choi Y: 7,8-dihydroxyflavone induces G1 arrest of the cell cycle in U937 human monocytic leukemia cells via induction of the Cdk inhibitor p27 and downregulation of pRB phosphorylation. Oncol Rep 28: 353-357, 2012.
APA
Park, H., Kim, G., Hyun, J., Kim, N., Kim, C., Kim, W. ... Choi, Y. (2012). 7,8-dihydroxyflavone induces G1 arrest of the cell cycle in U937 human monocytic leukemia cells via induction of the Cdk inhibitor p27 and downregulation of pRB phosphorylation. Oncology Reports, 28, 353-357. https://doi.org/10.3892/or.2012.1773
MLA
Park, H., Kim, G., Hyun, J., Kim, N., Kim, C., Kim, W., Yoo, Y., Choi, Y."7,8-dihydroxyflavone induces G1 arrest of the cell cycle in U937 human monocytic leukemia cells via induction of the Cdk inhibitor p27 and downregulation of pRB phosphorylation". Oncology Reports 28.1 (2012): 353-357.
Chicago
Park, H., Kim, G., Hyun, J., Kim, N., Kim, C., Kim, W., Yoo, Y., Choi, Y."7,8-dihydroxyflavone induces G1 arrest of the cell cycle in U937 human monocytic leukemia cells via induction of the Cdk inhibitor p27 and downregulation of pRB phosphorylation". Oncology Reports 28, no. 1 (2012): 353-357. https://doi.org/10.3892/or.2012.1773
Copy and paste a formatted citation
x
Spandidos Publications style
Park H, Kim G, Hyun J, Kim N, Kim C, Kim W, Yoo Y and Choi Y: 7,8-dihydroxyflavone induces G1 arrest of the cell cycle in U937 human monocytic leukemia cells via induction of the Cdk inhibitor p27 and downregulation of pRB phosphorylation. Oncol Rep 28: 353-357, 2012.
APA
Park, H., Kim, G., Hyun, J., Kim, N., Kim, C., Kim, W. ... Choi, Y. (2012). 7,8-dihydroxyflavone induces G1 arrest of the cell cycle in U937 human monocytic leukemia cells via induction of the Cdk inhibitor p27 and downregulation of pRB phosphorylation. Oncology Reports, 28, 353-357. https://doi.org/10.3892/or.2012.1773
MLA
Park, H., Kim, G., Hyun, J., Kim, N., Kim, C., Kim, W., Yoo, Y., Choi, Y."7,8-dihydroxyflavone induces G1 arrest of the cell cycle in U937 human monocytic leukemia cells via induction of the Cdk inhibitor p27 and downregulation of pRB phosphorylation". Oncology Reports 28.1 (2012): 353-357.
Chicago
Park, H., Kim, G., Hyun, J., Kim, N., Kim, C., Kim, W., Yoo, Y., Choi, Y."7,8-dihydroxyflavone induces G1 arrest of the cell cycle in U937 human monocytic leukemia cells via induction of the Cdk inhibitor p27 and downregulation of pRB phosphorylation". Oncology Reports 28, no. 1 (2012): 353-357. https://doi.org/10.3892/or.2012.1773
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