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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2012 Volume 28 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2012 Volume 28 Issue 1

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Article

The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways

  • Authors:
    • Jin Meng
    • Hai-Hua Zhang
    • Chun-Xiang Zhou
    • Chen Li
    • Feng Zhang
    • Qi-Bing Mei

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an 710032, P.R. China, School of Clinical Medicine and Stomatology, The Fourth Military Medical University, Xi'an 710032, P.R. China, Department of Pharmacy, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, P.R. China
  • Pages: 384-388
    |
    Published online on: April 30, 2012
       https://doi.org/10.3892/or.2012.1793
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Abstract

Many chemotherapeutic agents induce apoptosis via a p53-dependent pathway. However, up to 50% of human cancers have p53 mutation and loss of p53 function. Histone deacetylase inhibitors (HDACIs) are emerging as a potentially important new class of anticancer agents. Here, we report that, Trichostatin A (TSA), a pan-HDAC inhibitor, could induce G2/M cell cycle arrest and apoptosis in both colorectal cancer cell lines with wild-type p53 (HT116 cells) and mutant p53 (HT29 cells), although HCT116 cells had more apoptotic cells than HT29 cells. TSA induces apoptosis in both cell lines via the mitochondrial pathway as indicated by decrease of the mitochondrial membrane potential (MMP) and activation of caspase-3. Additionally, TSA induces expression of the pro-apoptotic protein Bax and decreases the expression of the anti-apoptotic proteins Bcl-2 and Bcl-xL in both cell lines. Bax knockdown by siRNA significantly impaired TSA-induced apoptosis in both cell lines. These data suggest that TSA induces G2/M cell cycle arrest and Bax-dependent apoptosis in colorectal cancer cells (HCT116 cells and HT29 cells) by both p53-dependent and -independent mechanisms. However, cells with normal p53 function are more sensitive to TSA-induced apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Meng J, Zhang H, Zhou C, Li C, Zhang F and Mei Q: The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. Oncol Rep 28: 384-388, 2012.
APA
Meng, J., Zhang, H., Zhou, C., Li, C., Zhang, F., & Mei, Q. (2012). The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. Oncology Reports, 28, 384-388. https://doi.org/10.3892/or.2012.1793
MLA
Meng, J., Zhang, H., Zhou, C., Li, C., Zhang, F., Mei, Q."The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways". Oncology Reports 28.1 (2012): 384-388.
Chicago
Meng, J., Zhang, H., Zhou, C., Li, C., Zhang, F., Mei, Q."The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways". Oncology Reports 28, no. 1 (2012): 384-388. https://doi.org/10.3892/or.2012.1793
Copy and paste a formatted citation
x
Spandidos Publications style
Meng J, Zhang H, Zhou C, Li C, Zhang F and Mei Q: The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. Oncol Rep 28: 384-388, 2012.
APA
Meng, J., Zhang, H., Zhou, C., Li, C., Zhang, F., & Mei, Q. (2012). The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. Oncology Reports, 28, 384-388. https://doi.org/10.3892/or.2012.1793
MLA
Meng, J., Zhang, H., Zhou, C., Li, C., Zhang, F., Mei, Q."The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways". Oncology Reports 28.1 (2012): 384-388.
Chicago
Meng, J., Zhang, H., Zhou, C., Li, C., Zhang, F., Mei, Q."The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways". Oncology Reports 28, no. 1 (2012): 384-388. https://doi.org/10.3892/or.2012.1793
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