Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats
- F Joarder
- H AbouIssa
- F Robertson
- M Parrett
- G Alshafie
- R Harris
Affiliations: OHIO STATE UNIV, SCH PUBL HLTH, CTR COMPREHENS CANC, COLL MED & PUBL HLTH, COLUMBUS, OH 43210 USA. OHIO STATE UNIV, DEPT SURG, COLUMBUS, OH 43210 USA. OHIO STATE UNIV, DEPT MED MICROBIOL & IMMUNOL, COLUMBUS, OH 43210 USA.
- Published online on: November 1, 1997 https://doi.org/10.3892/or.4.6.1271
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We examined effects of ibuprofen on the growth and development of DMBA-induced mammary cancers in mature female Sprague-Dawley rats. Ibuprofen was added to the standard diet at approximately 1,000 mg/kg rodent chow, resulting in an average daily dose of 25 mg per day per 0.25 kg rat. After five weeks of ibuprofen treatment, there was a 37% reduction in tumor volume compared to a 260% increase in the volume of tumors in untreated rats (p<0.001). These results suggest that ibuprofen may have potential in the chemoprevention and treatment of breast cancer.