Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats

  • Authors:
    • F Joarder
    • H AbouIssa
    • F Robertson
    • M Parrett
    • G Alshafie
    • R Harris
  • View Affiliations

  • Published online on: November 1, 1997     https://doi.org/10.3892/or.4.6.1271
  • Pages: 1271-1273
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Abstract

We examined effects of ibuprofen on the growth and development of DMBA-induced mammary cancers in mature female Sprague-Dawley rats. Ibuprofen was added to the standard diet at approximately 1,000 mg/kg rodent chow, resulting in an average daily dose of 25 mg per day per 0.25 kg rat. After five weeks of ibuprofen treatment, there was a 37% reduction in tumor volume compared to a 260% increase in the volume of tumors in untreated rats (p<0.001). These results suggest that ibuprofen may have potential in the chemoprevention and treatment of breast cancer.

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November 1997
Volume 4 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Joarder, F., AbouIssa, H., Robertson, F., Parrett, M., Alshafie, G., & Harris, R. (1997). Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats. Oncology Reports, 4, 1271-1273. https://doi.org/10.3892/or.4.6.1271
MLA
Joarder, F., AbouIssa, H., Robertson, F., Parrett, M., Alshafie, G., Harris, R."Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats". Oncology Reports 4.6 (1997): 1271-1273.
Chicago
Joarder, F., AbouIssa, H., Robertson, F., Parrett, M., Alshafie, G., Harris, R."Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats". Oncology Reports 4, no. 6 (1997): 1271-1273. https://doi.org/10.3892/or.4.6.1271