Tumor-specific apoptosis induced by the human monoclonal antibody SC-1: a new therapeutical approach for stomach cancer.

  • Authors:
    • H P Vollmers
    • F Hensel
    • R Hermann
    • J Dämmrich
    • E Wozniak
    • P Gessner
    • B Herrmann
    • U Zimmermann
    • H K Müller-Hermelink
  • View Affiliations

  • Published online on: January 1, 1998     https://doi.org/10.3892/or.5.1.35
  • Pages: 35-75
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Abstract

Stomach cancer is one of the most frequently occurring cancers worldwide, with a very poor prognosis, even after complete gastrectomy. We describe here an alternative therapeutical approach using a human monoclonal antibody (SC-1), which was isolated from a patient with diffuse-type gastric adenocarcinoma. We demonstrate that the antibody significantly reduces stomach cancer growth in vivo, by inducing tumor-specific apoptosis and that the antibody, even delivered in high doses, shows no toxic crossreactivity to other organs or tissues. The data presented here show that tumor-specific apoptosis can be induced and they give rise to the hope that human monoclonal antibodies with biological activity might present a completely new type of adjuvant cancer therapy.

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January 1998
Volume 5 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Vollmers, H., Hensel, F., Hermann, R., Dämmrich, J., Wozniak, E., Gessner, P. ... Müller-Hermelink, H. (1998). Tumor-specific apoptosis induced by the human monoclonal antibody SC-1: a new therapeutical approach for stomach cancer.. Oncology Reports, 5, 35-75. https://doi.org/10.3892/or.5.1.35
MLA
Vollmers, H., Hensel, F., Hermann, R., Dämmrich, J., Wozniak, E., Gessner, P., Herrmann, B., Zimmermann, U., Müller-Hermelink, H."Tumor-specific apoptosis induced by the human monoclonal antibody SC-1: a new therapeutical approach for stomach cancer.". Oncology Reports 5.1 (1998): 35-75.
Chicago
Vollmers, H., Hensel, F., Hermann, R., Dämmrich, J., Wozniak, E., Gessner, P., Herrmann, B., Zimmermann, U., Müller-Hermelink, H."Tumor-specific apoptosis induced by the human monoclonal antibody SC-1: a new therapeutical approach for stomach cancer.". Oncology Reports 5, no. 1 (1998): 35-75. https://doi.org/10.3892/or.5.1.35