Screening of potential cancer preventing chemicals for induction of glutathione in rat liver cells.

  • Authors:
    • E L White
    • L J Ross
    • S M Schmid
    • G J Kelloff
    • V E Steele
    • D L Hill
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  • Published online on: March 1, 1998     https://doi.org/10.3892/or.5.2.507
  • Pages: 507-519
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Abstract

With BRL 3A hepatocytes, a series of selected, potentially chemopreventive chemicals was evaluated for their capacity to elevate glutathione (GSH) levels. Since sodium selenite consistently increased GSH levels by approximately 70%, it was selected as a positive control. Of 62 test chemicals, eighteen stimulated GSH levels by >30%, but eleven of these had only a modest effect or displayed considerable toxicity. At non-toxic concentrations, seven compounds had substantial activity: black tea extract (decaffeinated), trans-chalcone, N-ethyl-9-cis-retinamide, indole-3-carbinol, dehydroepiandrosterone (DHEA) curcumin and N-(4-carboxyphenyl)retinamide. These should be considered for further development as cancer preventive agents.

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March 1998
Volume 5 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
White, E., Ross, L., Schmid, S., Kelloff, G., Steele, V., & Hill, D. (1998). Screening of potential cancer preventing chemicals for induction of glutathione in rat liver cells.. Oncology Reports, 5, 507-519. https://doi.org/10.3892/or.5.2.507
MLA
White, E., Ross, L., Schmid, S., Kelloff, G., Steele, V., Hill, D."Screening of potential cancer preventing chemicals for induction of glutathione in rat liver cells.". Oncology Reports 5.2 (1998): 507-519.
Chicago
White, E., Ross, L., Schmid, S., Kelloff, G., Steele, V., Hill, D."Screening of potential cancer preventing chemicals for induction of glutathione in rat liver cells.". Oncology Reports 5, no. 2 (1998): 507-519. https://doi.org/10.3892/or.5.2.507