Screening of potential cancer-preventing chemicals for inhibition of induction of ornithine decarboxylase in epithelial cells from rat trachea.
- E L White
- L J Ross
- S M Schmid
- G J Kelloff
- V E Steele
- D L Hill
Affiliations: Southern Research Institute, P.O. Box 55305, Birmingham, AL 35255-5305, USA.
- Published online on: May 1, 1998 https://doi.org/10.3892/or.5.3.717
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Sixty-one selected chemicals were evaluated in rat tracheal epithelial (2C5) cells for their capacity to inhibit induction (or inhibit directly) the enzyme ornithine decarboxylase, the activity of which is associated with cell growth and division. a-Difluoromethylornithine (DFMO) was used as a positive control. At non-toxic concentrations, six test compounds had substantial activity (values for IC50 DFMO/IC50 compound >1): N-(2-carboxyphenyl)-all-trans-retinamide, ZK 119010 ¿2-(4-hydroxyphenyl)-3-methyl-1-[6-(1-pyrrolidinyl)hexyl]-1H-indol-5- ol¿, curcumin, 18-a-olean-12-ene-3 ,23,28-triol, genistein and phenethyl isothiocyanate. These should be considered for further development as cancer preventive agents.