Antitumor effects of fotemustine and busulfan against a human neuroblastoma xenograft.

  • Authors:
    • H Ikeda
    • Y Tsuchida
    • J Wu
    • N Suzuki
    • M Kuroiwa
    • S H Choi
    • A Morikawa
  • View Affiliations

  • Published online on: November 1, 2000     https://doi.org/10.3892/or.7.6.1265
  • Pages: 1265-1273
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Abstract

We examined whether or not fotemustine, a new nitrosourea derivative, and busulfan, an agent already clinically used, are effective against human neuroblastoma, using a human neuroblastoma xenograft model designated TNB9. The maximum inhibition rate (MIR) of fotemustine against the TNB9 model was 44.6% with a total dose of fotemustine of 75 mg/kg, indicating that fotemustine is not effective against TNB9. The MIR of busulfan against the same model was 26.7% when a total dose of 135 mg/kg was administered orally to nude mice. Busulfan was also suspended in carboxy-methylcellulose, and was administered intraperitoneally. The MIRs were 19.4% and 36. 4% when busulfan was administered intraperitoneally at a total dose of 40 mg/kg and 60 mg/kg, respectively. The total doses of 40 mg/kg and 60 mg/kg did not show any adverse effects on mice, but were found to be ineffective against TNB9, indicating that busulfan might not be an effective chemotherapeutic agent against human neuroblastoma.

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Nov-Dec 2000
Volume 7 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ikeda H, Tsuchida Y, Wu J, Suzuki N, Kuroiwa M, Choi S and Morikawa A: Antitumor effects of fotemustine and busulfan against a human neuroblastoma xenograft.. Oncol Rep 7: 1265-1273, 2000.
APA
Ikeda, H., Tsuchida, Y., Wu, J., Suzuki, N., Kuroiwa, M., Choi, S., & Morikawa, A. (2000). Antitumor effects of fotemustine and busulfan against a human neuroblastoma xenograft.. Oncology Reports, 7, 1265-1273. https://doi.org/10.3892/or.7.6.1265
MLA
Ikeda, H., Tsuchida, Y., Wu, J., Suzuki, N., Kuroiwa, M., Choi, S., Morikawa, A."Antitumor effects of fotemustine and busulfan against a human neuroblastoma xenograft.". Oncology Reports 7.6 (2000): 1265-1273.
Chicago
Ikeda, H., Tsuchida, Y., Wu, J., Suzuki, N., Kuroiwa, M., Choi, S., Morikawa, A."Antitumor effects of fotemustine and busulfan against a human neuroblastoma xenograft.". Oncology Reports 7, no. 6 (2000): 1265-1273. https://doi.org/10.3892/or.7.6.1265