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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January-February 2002 Volume 9 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-February 2002 Volume 9 Issue 1

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Article

Cell cycle arrest and the induction of apoptosis in pancreatic cancer cells exposed to adenosine triphosphate in vitro

  • Authors:
    • Takayuki Yamada
    • Fumikazu Okajima
    • Mohammed Akbar
    • Hideaki Tomura
    • T. Narita
    • Tatsuya Yamada
    • Susumu Ohwada
    • Yasuo Morishita
    • Yoichi Kondo

  • View Affiliations / Copyright

    Affiliations: Second Department of Surgery, Gunma University, Showamachi, Gunma 371-8511, Japan
  • Pages: 113-117
    |
    Published online on: January 1, 2002
       https://doi.org/10.3892/or.9.1.113
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Abstract

Adenosine triphosphate (ATP) has been shown to be an inhibitory or a stimulatory agent for cell growth in various types of cells. Here, we studied the effects of extracellular ATP on two pancreatic cancer cell lines, PK-1 and YAPC established by us. In both cell lines, ATP inhibited cell growth in a time- and dose-dependent manner, whereas the same doses of ATP stimulated DNA synthesis. Flow cytometric analysis of the cells incubated with or without ATP demonstrated the ATP-induced striking increase in cells at S-phase. The same analysis showed also the increase in sub-G0/G1 population in the same analysis and the electrophoretic pattern of DNA showed the occurrence of ATP-induced cell disintegration likely to be apoptosis. We suggest that extracellular ATP is cytotoxic for pancreatic cancer cells because of its induction of cell cycle arrest at S-phase and cell death, possibly apoptosis, overcoming the promotion of the entry into S-phase.

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Copy and paste a formatted citation
Spandidos Publications style
Yamada T, Okajima F, Akbar M, Tomura H, Narita T, Yamada T, Ohwada S, Morishita Y and Kondo Y: Cell cycle arrest and the induction of apoptosis in pancreatic cancer cells exposed to adenosine triphosphate in vitro. Oncol Rep 9: 113-117, 2002.
APA
Yamada, T., Okajima, F., Akbar, M., Tomura, H., Narita, T., Yamada, T. ... Kondo, Y. (2002). Cell cycle arrest and the induction of apoptosis in pancreatic cancer cells exposed to adenosine triphosphate in vitro. Oncology Reports, 9, 113-117. https://doi.org/10.3892/or.9.1.113
MLA
Yamada, T., Okajima, F., Akbar, M., Tomura, H., Narita, T., Yamada, T., Ohwada, S., Morishita, Y., Kondo, Y."Cell cycle arrest and the induction of apoptosis in pancreatic cancer cells exposed to adenosine triphosphate in vitro". Oncology Reports 9.1 (2002): 113-117.
Chicago
Yamada, T., Okajima, F., Akbar, M., Tomura, H., Narita, T., Yamada, T., Ohwada, S., Morishita, Y., Kondo, Y."Cell cycle arrest and the induction of apoptosis in pancreatic cancer cells exposed to adenosine triphosphate in vitro". Oncology Reports 9, no. 1 (2002): 113-117. https://doi.org/10.3892/or.9.1.113
Copy and paste a formatted citation
x
Spandidos Publications style
Yamada T, Okajima F, Akbar M, Tomura H, Narita T, Yamada T, Ohwada S, Morishita Y and Kondo Y: Cell cycle arrest and the induction of apoptosis in pancreatic cancer cells exposed to adenosine triphosphate in vitro. Oncol Rep 9: 113-117, 2002.
APA
Yamada, T., Okajima, F., Akbar, M., Tomura, H., Narita, T., Yamada, T. ... Kondo, Y. (2002). Cell cycle arrest and the induction of apoptosis in pancreatic cancer cells exposed to adenosine triphosphate in vitro. Oncology Reports, 9, 113-117. https://doi.org/10.3892/or.9.1.113
MLA
Yamada, T., Okajima, F., Akbar, M., Tomura, H., Narita, T., Yamada, T., Ohwada, S., Morishita, Y., Kondo, Y."Cell cycle arrest and the induction of apoptosis in pancreatic cancer cells exposed to adenosine triphosphate in vitro". Oncology Reports 9.1 (2002): 113-117.
Chicago
Yamada, T., Okajima, F., Akbar, M., Tomura, H., Narita, T., Yamada, T., Ohwada, S., Morishita, Y., Kondo, Y."Cell cycle arrest and the induction of apoptosis in pancreatic cancer cells exposed to adenosine triphosphate in vitro". Oncology Reports 9, no. 1 (2002): 113-117. https://doi.org/10.3892/or.9.1.113
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