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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March-April 2002 Volume 9 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Polymorphism analysis of CYP3A5 in myeloid leukemia

  • Authors:
    • Ta-Chih Liu
    • Sheng-Fung Lin
    • Tyen-Po Chen
    • Jan-Gowth Chang

  • View Affiliations / Copyright

    Affiliations: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  • Pages: 327-329
    |
    Published online on: March 1, 2002
       https://doi.org/10.3892/or.9.2.327
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Abstract

The human cytochrome P450 (CYP) metabolizes more than 100 structurally diverse exogenous and endogenous molecules. The CYP3A5 is a major P450 enzyme in the liver and represents 50% of the total hepatic CYP3A content in people expressing CYP3A5. The single nucleotide polymorphisms in CYP3A5*3 and CYP3A5*6 that resulted in the absence of CYP3A5 from tissues were noted in some people. Polymorphisms of potential relevance to leukemia and myelodysplastic syndrome (MDS) have been described for various CYP. The bone marrow and/or peripheral blood from 188 acute myeloid leukemia (AML) patients, 101 chronic myeloid leukemia (CML), 40 MDS, and 270 normal controls were analyzed by a PCR-RFLP assay to evaluate the association of the CYP3A5 polymorphisms with myeloid leukemia. Our data showed that 15/188 (8%), 8/101 (7.9%), and 3/40 (7.5%) of the patients (i.e., 188 AML, 101 CML, 40 MDS) were CYP3A5*1/*1; 88/188 (46.8%), 47/101 (46.5%), and 20/40 (50%) were CYP3A5*1/*3; and 85/188 (45.2%), 46/101 (45.5%), and 17/40 (42.5%) carried the CYP3A5*3/*3 genotype, respectively. CYP3A5*6 was not found in any of the patients' specimens. Similar frequencies of CYP3A5*3 were observed in the leukemic patients and normal controls. Consequently, the finding suggests that the CYP3A5 polymorphism was not associated with the risk of myeloid leukemia.

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Copy and paste a formatted citation
Spandidos Publications style
Liu T, Lin S, Chen T and Chang J: Polymorphism analysis of CYP3A5 in myeloid leukemia. Oncol Rep 9: 327-329, 2002.
APA
Liu, T., Lin, S., Chen, T., & Chang, J. (2002). Polymorphism analysis of CYP3A5 in myeloid leukemia. Oncology Reports, 9, 327-329. https://doi.org/10.3892/or.9.2.327
MLA
Liu, T., Lin, S., Chen, T., Chang, J."Polymorphism analysis of CYP3A5 in myeloid leukemia". Oncology Reports 9.2 (2002): 327-329.
Chicago
Liu, T., Lin, S., Chen, T., Chang, J."Polymorphism analysis of CYP3A5 in myeloid leukemia". Oncology Reports 9, no. 2 (2002): 327-329. https://doi.org/10.3892/or.9.2.327
Copy and paste a formatted citation
x
Spandidos Publications style
Liu T, Lin S, Chen T and Chang J: Polymorphism analysis of CYP3A5 in myeloid leukemia. Oncol Rep 9: 327-329, 2002.
APA
Liu, T., Lin, S., Chen, T., & Chang, J. (2002). Polymorphism analysis of CYP3A5 in myeloid leukemia. Oncology Reports, 9, 327-329. https://doi.org/10.3892/or.9.2.327
MLA
Liu, T., Lin, S., Chen, T., Chang, J."Polymorphism analysis of CYP3A5 in myeloid leukemia". Oncology Reports 9.2 (2002): 327-329.
Chicago
Liu, T., Lin, S., Chen, T., Chang, J."Polymorphism analysis of CYP3A5 in myeloid leukemia". Oncology Reports 9, no. 2 (2002): 327-329. https://doi.org/10.3892/or.9.2.327
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