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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2002 Volume 9 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September-October 2002 Volume 9 Issue 5

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Article

Genetic alterations related to lymph node metastasis and peritoneal dissemination in epithelial ovarian cancers

  • Authors:
    • Kenji Umayahara
    • Fumitaka Numa
    • Akiko Inokuma
    • Kotaro Sueoka
    • Keiko Kawasaki
    • Hiroshi Hirakawa
    • Tomoko Emoto
    • Yuko Sakaguchi
    • Shugo Nawata
    • Hidenobu Ogata
    • Masaru Sakamoto
    • Katsuhiko Hasumi
    • Shigeto Kawauchi
    • Kohsuke Sasaki
    • Hiroshi Kato

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan. kenji-u@po.cc.yamaguchi-u.ac.jp
  • Pages: 1115-1119
    |
    Published online on: September 1, 2002
       https://doi.org/10.3892/or.9.5.1115
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Abstract

Genetic alterations are assumed to be necessary for the development and progression of ovarian cancer. However, the genetic alterations that occur during lymph node metastasis and peritoneal dissemination are poorly understood. In the present study, we used comparative genomic hybridization to detect genetic alterations in 30 tumors from patients with primary ovarian cancers and analyzed the associations of these genetic alterations with clinical stage and surgical pathological factors, such as histological grade, lymph node metastasis, and peritoneal dissemination. The total number of genetic alterations per tumor ranged from 0 to 39, with an average of 17.7 alterations per tumor. Among the genetic alterations in ovarian cancers, gains on chromosomes 8q and 3q and losses on chromosomes 17p, 18q, and 4q were observed frequently. Although the difference in total numbers of genetic alterations between early-stage tumors and advanced-stage tumors was not significant, the difference was significant when high-grade cancers were compared with low-grade cancers. Eight regions on seven chromosomes showed genetic alterations related to lymph node metastasis or peritoneal dissemination. Gain at 11q13-q14 and loss at 17q11.2-q21 were related not only to lymph node metastasis and peritoneal dissemination but also to clinical stage and histological grade.

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Copy and paste a formatted citation
Spandidos Publications style
Umayahara K, Numa F, Inokuma A, Sueoka K, Kawasaki K, Hirakawa H, Emoto T, Sakaguchi Y, Nawata S, Ogata H, Ogata H, et al: Genetic alterations related to lymph node metastasis and peritoneal dissemination in epithelial ovarian cancers. Oncol Rep 9: 1115-1119, 2002.
APA
Umayahara, K., Numa, F., Inokuma, A., Sueoka, K., Kawasaki, K., Hirakawa, H. ... Kato, H. (2002). Genetic alterations related to lymph node metastasis and peritoneal dissemination in epithelial ovarian cancers. Oncology Reports, 9, 1115-1119. https://doi.org/10.3892/or.9.5.1115
MLA
Umayahara, K., Numa, F., Inokuma, A., Sueoka, K., Kawasaki, K., Hirakawa, H., Emoto, T., Sakaguchi, Y., Nawata, S., Ogata, H., Sakamoto, M., Hasumi, K., Kawauchi, S., Sasaki, K., Kato, H."Genetic alterations related to lymph node metastasis and peritoneal dissemination in epithelial ovarian cancers". Oncology Reports 9.5 (2002): 1115-1119.
Chicago
Umayahara, K., Numa, F., Inokuma, A., Sueoka, K., Kawasaki, K., Hirakawa, H., Emoto, T., Sakaguchi, Y., Nawata, S., Ogata, H., Sakamoto, M., Hasumi, K., Kawauchi, S., Sasaki, K., Kato, H."Genetic alterations related to lymph node metastasis and peritoneal dissemination in epithelial ovarian cancers". Oncology Reports 9, no. 5 (2002): 1115-1119. https://doi.org/10.3892/or.9.5.1115
Copy and paste a formatted citation
x
Spandidos Publications style
Umayahara K, Numa F, Inokuma A, Sueoka K, Kawasaki K, Hirakawa H, Emoto T, Sakaguchi Y, Nawata S, Ogata H, Ogata H, et al: Genetic alterations related to lymph node metastasis and peritoneal dissemination in epithelial ovarian cancers. Oncol Rep 9: 1115-1119, 2002.
APA
Umayahara, K., Numa, F., Inokuma, A., Sueoka, K., Kawasaki, K., Hirakawa, H. ... Kato, H. (2002). Genetic alterations related to lymph node metastasis and peritoneal dissemination in epithelial ovarian cancers. Oncology Reports, 9, 1115-1119. https://doi.org/10.3892/or.9.5.1115
MLA
Umayahara, K., Numa, F., Inokuma, A., Sueoka, K., Kawasaki, K., Hirakawa, H., Emoto, T., Sakaguchi, Y., Nawata, S., Ogata, H., Sakamoto, M., Hasumi, K., Kawauchi, S., Sasaki, K., Kato, H."Genetic alterations related to lymph node metastasis and peritoneal dissemination in epithelial ovarian cancers". Oncology Reports 9.5 (2002): 1115-1119.
Chicago
Umayahara, K., Numa, F., Inokuma, A., Sueoka, K., Kawasaki, K., Hirakawa, H., Emoto, T., Sakaguchi, Y., Nawata, S., Ogata, H., Sakamoto, M., Hasumi, K., Kawauchi, S., Sasaki, K., Kato, H."Genetic alterations related to lymph node metastasis and peritoneal dissemination in epithelial ovarian cancers". Oncology Reports 9, no. 5 (2002): 1115-1119. https://doi.org/10.3892/or.9.5.1115
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