[Corrigendum] Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K‑AKT‑mTOR pathway in osteoarthritic chondrocytes

• Authors:
  • Yubiao Zhang
  • Weisong Cai
  • Guangtao Han
  • Siqi Zhou
  • Jianping Li
  • Mao Chen
  • Haohuan Li

• View Affiliations

  
  Affiliations: Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
• Published online on: January 17, 2022     https://doi.org/10.3892/ijmm.2022.5085
• Article Number: 30

• Copyright : © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

Article

Int J Mol Med 45: [Related article:] 1225-1236, 2020; DOI: 10.3892/ijmm.2020.4491

Following the publication of the above article (and a Corrigendum that has already been published with the intention of showing the corrected version of Fig. 6 (DOI:10.3892/ijmm.2020.4786; published online on November 11, 2020), an interested reader drew to the authors' attention that, in Fig. 5B on p. 1233, the 'OA' and 'OA+IGF-1+PNS' data panels appeared to show overlapping data.

Figure 5 PNS regulates the expression levels of degeneration-related genes and ultrastructural changes in cartilage. (A) Immunofluorescence staining showing the protein levels of COL-II and the levels of (B) MMP-3 and (C) MMP-13 along with (D) quantification. Quantification of the (E) MMP-3 and (F) MMP-13 levels. (G) Reverse transcription-PCR results are shown for COL-II, MMP-3 and MMP-13. The data are expressed as the means ± standard deviation (n=3). *P<0.05 vs. control; #P<0.05 vs. OA and &P<0.05 vs. OA+IGF-1. MMP, matrix metalloproteinase; OA, osteoarthritis; PNS, Panax notoginseng saponins.

The authors have re-examined their original data, and realize that Fig. 5 was assembled incorrectly; essentially, the 'OA+IGF-1+PNS' data panel for Fig. 5B was selected in error. The corrected version of Fig. 5 is shown on the next page. Note that this inadvertent error did not affect the main conclusions reported in this study. The authors are grateful to the Editor of International Journal of Molecular Medicine for granting them the opportunity to publish this Corrigendum, and apologize to the readership for any inconvenience caused.

Figure 5 PNS regulates the expression levels of degeneration-related genes and ultrastructural changes in cartilage. (A) Immunofluorescence staining showing the protein levels of COL-II and the levels of (B) MMP-3 and (C) MMP-13 along with (D) quantification. Quantification of the (E) MMP-3 and (F) MMP-13 levels. (G) Reverse transcription-PCR results are shown for COL-II, MMP-3 and MMP-13. The data are expressed as the means ± standard deviation (n=3). *P<0.05 vs. control; #P<0.05 vs. OA and &P<0.05 vs. OA+IGF-1. MMP, matrix metalloproteinase; OA, osteoarthritis; PNS, Panax notoginseng saponins.