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Review

Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis (Review)

  • Authors:
    • Juria Akasaka
    • Chiaki Uekuri
    • Hiroshi Shigetomi
    • Matsuki Koike
    • Hiroshi Kobayashi
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Nara Medical University, Nara 634-8522, Japan
  • Pages: 13-17
    |
    Published online on: October 11, 2012
       https://doi.org/10.3892/br.2012.19
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Abstract

Endometriosis is associated with pelvic pain and female infertility. Endometriosis induces inflammation and is vulnerable to oxidative stress damage. To update and summarize the literature concerning the mechanisms that serve to protect genomic DNA from the oxidative damage, the present study reviews the English‑language literature for biochemical studies on the transcription factor hepatocyte nuclear factor (HNF)‑1β target genes. Findings demonstrated that retrograde flow of the menstrual blood might give rise to endometriosis. Iron may have a significant impact on endometriosis gene expression. HNF‑1β regulates tissue‑specific gene expression in endometriosis, as well as the expression of several genes, including CD44v9, which binds several molecules, including hyaluronan, epidermal growth factor receptor (EGFR), leukemia‑associated Rho‑guanine nucleotide exchange factor (LARG), IQ motif containing GTPase activating protein 1 (IQGAP1), macrophage migration inhibitory factor (MIF), major histocompatibility complex, class II invariant chain (CD74), cystine transporter subunit (xCT), Fas and extracellular matrix (ECM) proteins. The CD44v9 system is involved in cell migration, growth, survival, anti‑apoptosis, immune response and anti‑oxidative stress through maintaining higher levels of antioxidants. HNF‑1β may serve to alleviate damage and promote survival of cells experiencing stress by upregulating antioxidant protein expression. This review expands current knowledge on the molecular mechanisms underlying the oxidative stress protection provided by HNF‑1β and provides evidence that elevated HNF‑1β activity might be associated with the CD44v9‑dependent signaling cascades.
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1. 

Kato N, Sasou S and Motoyama T: Expression of hepatocyte nuclear factor-1β (HNF-1β) in clear cell tumors and endometriosis of the ovary. Mod Pathol. 19:83–89. 2006.

2. 

Kobayashi H, Yamada Y, Kanayama S, Furukawa N, Noguchi T, Haruta S, Yoshida S, Sakata M, Sado T and Oi H: The role of hepatocyte nuclear factor-1beta in the pathogenesis of clear cell carcinoma of the ovary. Int J Gynecol Cancer. 19:471–479. 2009. View Article : Google Scholar : PubMed/NCBI

3. 

Yamada Y, Shigetomi H, Onogi A, Haruta S, Kawaguchi R, Yoshida S, Furukawa N, Nagai A, Tanase Y, Tsunemi T, Oi H and Kobayashi H: Redox-active iron-induced oxidative stress in the pathogenesis of clear cell carcinoma of the ovary. Int J Gynecol Cancer. 21:1200–1207. 2011.PubMed/NCBI

4. 

Shigetomi H, Higashiura Y, Kajihara H and Kobayashi H: A potential link of oxidative stress and cell cycle regulation for development of endometriosis. Gynecol Endocrinol. May 17–2012.(Epub ahead of print).

5. 

Yoshioka K, Kunitomo M, Yanai K, Shimizu H, Nakasono S, Negishi T and Dateki M: Hepatocyte nuclear factor 1β induced by chemical stress accelerates cell proliferation and increases genomic instability in mouse liver. J Recept Signal Transduct Res. 31:132–138. 2011.

6. 

Verdeguer F, Le Corre S, Fischer E, Callens C, Garbay S, Doyen A, Igarashi P, Terzi F and Pontoglio M: A mitotic transcriptional switch in polycystic kidney disease. Nat Med. 16:106–110. 2010. View Article : Google Scholar : PubMed/NCBI

7. 

Ogata K, Shimamura Y, Hamada K, Hisa M, Bun M, Okada N, Inoue K, Taniguchi Y, Ishihara M, Kagawa T, Horino T, Fujimoto S and Terada Y: Upregulation of HNF-1β during experimental acute kidney injury plays a crucial role in renal tubule regeneration. Am J Physiol Renal Physiol. 303:F689–F699. 2012.

8. 

Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, Masuko T, Shimizu T, Ishikawa T, Kai K, Takahashi E, Imamura Y, Baba Y, Ohmura M, Suematsu M, Baba H and Saya H: CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(−) and thereby promotes tumor growth. Cancer Cell. 19:387–400. 2011.PubMed/NCBI

9. 

Jang Bl, Li Y, Graham DY and Cen P: The role of CD44 in the pathogenesis, diagnosis, and therapy of gastric cancer. Gut Liver. 5:397–405. 2011. View Article : Google Scholar : PubMed/NCBI

10. 

Lu D, Tawfik O, Pantazis C, Hobart W, Chapman J and Iczkowski K: Altered expression of CD44 and variant isoforms in human adenocarcinoma of the endocervix during progression. Gynecol Oncol. 75:84–90. 1999. View Article : Google Scholar : PubMed/NCBI

11. 

Koyama S, Maruyama T and Adachi S: Expression of epidermal growth factor receptor and CD44 splicing variants sharing exons 6 and 9 on gastric and esophageal carcinomas: a two-color flow-cytometric analysis. J Cancer Res Clin Oncol. 125:47–54. 1999. View Article : Google Scholar

12. 

Seki K, Yamaguchi A, Goi T, Nakagawara G, Matsukawa S, Urano T and Furukawa K: Inhibition of liver metastasis formation by anti-CD44 variant exon 9 monoclonal antibody. Int J Oncol. 11:1257–1261. 1997.PubMed/NCBI

13. 

Omara-Opyene AL, Qiu J, Shah GV and Iczkowski KA: Prostate cancer invasion is influenced more by expression of a CD44 isoform including variant 9 than by Muc18. Lab Invest. 84:894–907. 2004. View Article : Google Scholar : PubMed/NCBI

14. 

Goi T, Koneri K, Katayama K, Hirose K and Yamaguchi A: Evaluation of clinicopathological factors and the correlation between the adhesion molecule CD44 variant 9 expression and pulmonary metastases from colorectal cancers. Int Surg. 87:130–136. 2002.PubMed/NCBI

15. 

Okano K, Shimoda T and Matsumura Y: Clinicopathologic and immunohistochemical study of early colorectal cancer with liver metastases. J Gastroenterol. 34:334–340. 1999. View Article : Google Scholar : PubMed/NCBI

16. 

Rodríguez-Rodríguez L, Sancho-Torres I, Leakey P, Gibbon DG, Comerci JT, Ludlow JW and Mesonero C: CD44 splice variant expression in clear cell carcinoma of the ovary. Gynecol Oncol. 71:223–229. 1998.PubMed/NCBI

17. 

Eisterer W, Bechter O, Hilbe W, van Driel M, Lokhorst HM, Thaler J, Bloem AC, Günthert U and Stauder R: CD44 isoforms are differentially regulated in plasma cell dyscrasias and CD44v9 represents a new independent prognostic parameter in multiple myeloma. Leuk Res. 25:1051–1057. 2001. View Article : Google Scholar : PubMed/NCBI

18. 

Akisik E, Bavbek S and Dalay N: CD44 variant exons in leukemia and lymphoma. Pathol Oncol Res. 8:36–40. 2002. View Article : Google Scholar : PubMed/NCBI

19. 

Mielgo A, van Driel M, Bloem A, Landmann L and Günthert U: A novel antiapoptotic mechanism based on interference of Fas signaling by CD44 variant isoforms. Cell Death Differ. 13:465–477. 2006. View Article : Google Scholar : PubMed/NCBI

20. 

Echiburú-Chau C, Roy D and Calaf GM: Metastatic suppressor CD44 is related with oxidative stress in breast cancer cell lines. Int J Oncol. 39:1481–1489. 2011.PubMed/NCBI

21. 

Sato S, Miyauchi M, Takekoshi T, Zhao M, Kudo Y, Ogawa I, Kitagawa S, Fujita M and Takata T: Reduced expression of CD44 variant 9 is related to lymph node metastasis and poor survival in squamous cell carcinoma of tongue. Oral Oncol. 36:545–549. 2000. View Article : Google Scholar : PubMed/NCBI

22. 

Kahara N, Ozaki T, Doi T, Nishida K, Kawai A, Shibahara M and Inoue H: CD44 expression in soft tissue sarcomas. Virchows Arch. 436:574–578. 2000. View Article : Google Scholar : PubMed/NCBI

23. 

Imam H, Eriksson B and Oberg K: Expression of CD44 variant isoforms and association to the benign form of endocrine pancreatic tumours. Ann Oncol. 11:295–300. 2000. View Article : Google Scholar : PubMed/NCBI

24. 

Shimabukuro K, Toyama-Sorimachi N, Ozaki Y, Goi T, Furukawa K, Miyasaka M and Aso T: The expression patterns of standard and variant CD44 molecules in normal uterine cervix and cervical cancer. Gynecol Oncol. 64:26–34. 1997. View Article : Google Scholar : PubMed/NCBI

25. 

Wang SJ and Bourguignon LY: Role of hyaluronan-mediated CD44 signaling in head and neck squamous cell carcinoma progression and chemoresistance. Am J Pathol. 178:956–963. 2011. View Article : Google Scholar : PubMed/NCBI

26. 

Kozlova I, Ruusala A, Voytyuk O, Skandalis SS and Heldin P: IQGAP1 regulates hyaluronan-mediated fibroblast motility and proliferation. Cell Signal. 24:1856–1862. 2012. View Article : Google Scholar : PubMed/NCBI

27. 

Ohta S, Misawa A, Fukaya R, Inoue S, Kanemura Y, Okano H, Kawakami Y and Toda M: Macrophage migration inhibitory factor (MIF) promotes cell survival and proliferation of neural stem/progenitor cells. J Cell Sci. 125:3210–3220. 2012. View Article : Google Scholar : PubMed/NCBI

28. 

Zaytseva YY, Rychahou PG, Gulhati P, Elliott VA, Mustain WC, O’Connor K, Morris AJ, Sunkara M, Weiss HL, Lee EY and Evers BM: Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Cancer Res. 72:1504–1517. 2012. View Article : Google Scholar : PubMed/NCBI

29. 

Li J, Zha XM, Wang R, Li XD, Xu B, Xu YJ and Yin YM: Regulation of CD44 expression by tumor necrosis factor-α and its potential role in breast cancer cell migration. Biomed Pharmacother. 66:144–150. 2012.

30. 

Darzynkiewicz Z and Balazs EA: Genome integrity, stem cells and hyaluronan. Aging (Albany NY). 4:78–88. 2012.PubMed/NCBI

31. 

Pauloin T, Dutot M, Warnet JM and Rat P: In vitro modulation of preservative toxicity: high molecular weight hyaluronan decreases apoptosis and oxidative stress induced by benzalkonium chloride. Eur J Pharm Sci. 34:263–273. 2008. View Article : Google Scholar

32. 

Zhao H, Tanaka T, Mitlitski V, Heeter J, Balazs EA and Darzynkiewicz Z: Protective effect of hyaluronate on oxidative DNA damage in WI-38 and A549 cells. Int J Oncol. 32:1159–1167. 2008.PubMed/NCBI

33. 

Witz CA, Allsup KT, Montoya-Rodriguez IA, Vaughan SL, Centonze VE and Schenken RS: Pathogenesis of endometriosis - current research. Hum Fertil (Camb). 6:34–40. 2003. View Article : Google Scholar : PubMed/NCBI

34. 

Ketola K, Hilvo M, Hyötyläinen T, Vuoristo A, Ruskeepää AL, Orešič M, Kallioniemi O and Iljin K: Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress. Br J Cancer. 106:99–106. 2012. View Article : Google Scholar : PubMed/NCBI

35. 

Leir SH, Baker JE, Holgate ST and Lackie PM: Increased CD44 expression in human bronchial epithelial repair after damage or plating at low cell densities. Am J Physiol Lung Cell Mol Physiol. 278:L1129–L1137. 2000.PubMed/NCBI

36. 

Daraï E, Leblanc M, Walker-Combrouze F, Bringuier AF, Madelenat P and Scoazec JY: Expression of cadherins and CD44 isoforms in ovarian endometrial cysts. Hum Reprod. 13:1346–1352. 1998.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Akasaka J, Uekuri C, Shigetomi H, Koike M and Kobayashi H: Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis (Review). Biomed Rep 1: 13-17, 2013.
APA
Akasaka, J., Uekuri, C., Shigetomi, H., Koike, M., & Kobayashi, H. (2013). Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis (Review). Biomedical Reports, 1, 13-17. https://doi.org/10.3892/br.2012.19
MLA
Akasaka, J., Uekuri, C., Shigetomi, H., Koike, M., Kobayashi, H."Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis (Review)". Biomedical Reports 1.1 (2013): 13-17.
Chicago
Akasaka, J., Uekuri, C., Shigetomi, H., Koike, M., Kobayashi, H."Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis (Review)". Biomedical Reports 1, no. 1 (2013): 13-17. https://doi.org/10.3892/br.2012.19
Copy and paste a formatted citation
x
Spandidos Publications style
Akasaka J, Uekuri C, Shigetomi H, Koike M and Kobayashi H: Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis (Review). Biomed Rep 1: 13-17, 2013.
APA
Akasaka, J., Uekuri, C., Shigetomi, H., Koike, M., & Kobayashi, H. (2013). Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis (Review). Biomedical Reports, 1, 13-17. https://doi.org/10.3892/br.2012.19
MLA
Akasaka, J., Uekuri, C., Shigetomi, H., Koike, M., Kobayashi, H."Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis (Review)". Biomedical Reports 1.1 (2013): 13-17.
Chicago
Akasaka, J., Uekuri, C., Shigetomi, H., Koike, M., Kobayashi, H."Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis (Review)". Biomedical Reports 1, no. 1 (2013): 13-17. https://doi.org/10.3892/br.2012.19
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