Semen Ziziphi Spinosae and Fructus Gardeniae extracts synergistically improve learning and memory of a mouse model

Li,Baoli; Fu,Zhaoying; Hu,Rui; Chen,Yahui; Zhang,Zhengxiang

doi:10.3892/br.2012.38

March-April 2013 Volume 1 Issue 2

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March-April 2013 Volume 1 Issue 2

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Article

Semen Ziziphi Spinosae and Fructus Gardeniae extracts synergistically improve learning and memory of a mouse model

Authors:
- Baoli Li
- Zhaoying Fu
- Rui Hu
- Yahui Chen
- Zhengxiang Zhang
View Affiliations / Copyright

Affiliations: Department of Pharmacology, Medical College of Yan'an University, Yan'an 716000, P.R. China, Department of Molecular Biology, Medical College of Yan'an University, Yan'an 716000, P.R. China, Department of Pharmacology, Shanxi University of Traditional Chinese Medicine, Xi'an 712046, P.R. China, Department of Physiology, Medical College of Yan'an University, Yan'an 716000, P.R. China
Pages: 247-250
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Published online on: November 8, 2012

https://doi.org/10.3892/br.2012.38
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Abstract

Semen Ziziphi Spinosae (SZS) and Fructus Gardeniae (FG) are two herbs commonly used in traditional Chinese medicine. Previous studies have suggested that Fructus Gardeniae as well as Semen Ziziphi Spinosae are able to regulate the function of the central nervous system. However, their effect on learning and memory has yet to be elucidated. In this study, we examined the effect of SZS and FG on the learning and memory of mice using the methods of step‑through and ‑down passive avoidance tasks and Morris water maze tasks. The results showed that SZS and FG extracts have certain effects on improving the performance of the learning and memory-impaired mouse model. Of note, compound extracts of SZS and FG have a synergistic effect on the learning and memory of mice.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Semen Ziziphi Spinosae and Fructus Gardeniae extracts synergistically improve learning and memory of a mouse model

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