Semen Ziziphi Spinosae and Fructus Gardeniae extracts synergistically improve learning and memory of a mouse model

Li,Baoli; Fu,Zhaoying; Hu,Rui; Chen,Yahui; Zhang,Zhengxiang

doi:10.3892/br.2012.38

Semen Ziziphi Spinosae and Fructus Gardeniae extracts synergistically improve learning and memory of a mouse model

Authors:
- Baoli Li
- Zhaoying Fu
- Rui Hu
- Yahui Chen
- Zhengxiang Zhang
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Affiliations: Department of Pharmacology, Medical College of Yan'an University, Yan'an 716000, P.R. China, Department of Molecular Biology, Medical College of Yan'an University, Yan'an 716000, P.R. China, Department of Pharmacology, Shanxi University of Traditional Chinese Medicine, Xi'an 712046, P.R. China, Department of Physiology, Medical College of Yan'an University, Yan'an 716000, P.R. China
Published online on: November 8, 2012 https://doi.org/10.3892/br.2012.38
Pages: 247-250

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Abstract

Semen Ziziphi Spinosae (SZS) and Fructus Gardeniae (FG) are two herbs commonly used in traditional Chinese medicine. Previous studies have suggested that Fructus Gardeniae as well as Semen Ziziphi Spinosae are able to regulate the function of the central nervous system. However, their effect on learning and memory has yet to be elucidated. In this study, we examined the effect of SZS and FG on the learning and memory of mice using the methods of step‑through and ‑down passive avoidance tasks and Morris water maze tasks. The results showed that SZS and FG extracts have certain effects on improving the performance of the learning and memory-impaired mouse model. Of note, compound extracts of SZS and FG have a synergistic effect on the learning and memory of mice.

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1	Yan ZH: Chinese Materia Medica. 2nd edition. People’s Medical Publishing House; Beijing: pp. 148–150. 2010
2	Hou SL: Detailed annotation of eight hundred traditional Chinese medicines. Science and Technology Press of Henan; Zhengzhou: pp. 680–682. 2009
3	Li J: Formulas of traditional Chinese medicine. Higher Education press; Beijing: pp. 233–234. 2006
4	Zhang TM: Chinese Materia Medica. Higher Education press; Beijing: pp. 697–698. 2006
5	Zhang TM: Chinese Materia Medica. Beijing: Higher Education press; pp. 380–382. 2006
6	Li B, Xia C and Yuan B: Sedative and hypnotic effects of oil of spine date seeds from different extraction technologies in mice. J Xian Jiaotong Univ Med Sci. 29:227–229. 2008.(In Chinese).
7	Zhang Z, Li B, Chen Y, et al: Assay of the compositions of the compound oil of semen Ziziphi spinosae and fructus Gardeniae. J Shanxi Med Univ. 38:792–793. 2009.
8	Li B, Chen Y, Zhang Z, et al: Effect of compound jujube seed oil and gardenia oil on improving the ability of learning and memory in mice. J Xian Jiaotong Univ Med Sci. 31:673–676. 7072010.
9	Akanmu MA, Adeosun SO and Ilesanmi OR: Neuropharmacological effects of oleamide in male and female mice. Behav Brain Res. 182:88–94. 2007. View Article : Google Scholar : PubMed/NCBI
10	Micale V, Cristino L, Tamburella A, et al: Enhanced cognitive performance of dopamine D3 receptor ‘knock-out’ mice in the step-through passive-avoidance test: assessing the role of the endocannabinoid/endovanilloid systems. Pharmacol Res. 61:531–536. 2010.
11	Ahmadi S, Malekmohammadi N and Zarrindast MR: Repeated histamine pretreatment decreased amnesia induced by post-training administration of the drug in a step-down inhibitory avoidance test in mice. Arch Iran Med. 13:209–216. 2010.PubMed/NCBI
12	Yang X, Sheng W, Sun GY, et al: Effects of fatty acid unsaturation numbers on membrane fluidity and α-secretase-dependent amyloid precursor protein processing. Neurochem Int. 58:321–329. 2011.PubMed/NCBI
13	Saha SS, Chakraborty A, Ghosh S, et al: Comparative study of hypocholesterolemic and hypolipidemic effects of conjugated linolenic acid isomers against induced biochemical perturbations and aberration in erythrocyte membrane fluidity. Eur J Nutr. 51:483–495. 2012. View Article : Google Scholar
14	Lauretani F, Bandinelli S, Bartali B, et al: Omega-6 and omega-3 fatty acids predict accelerated decline of peripheral nerve function in older persons. Eur J Neurol. 14:801–808. 2007. View Article : Google Scholar : PubMed/NCBI
15	Villegas-Comonfort S, Serna-Marquez N, Galindo-Hernandez O, et al: Arachidonic acid induces an increase of β-1,4-galactosyltransferase I expression in MDA-MB-231 breast cancer cells. J Cell Biochem. 113:3330–3341. 2012.
16	Rossen NS, Hansen AJ, Selhuber-Unkel C, et al: Arachidonic acid randomizes endothelial cell motion and regulates adhesion and migration. PLoS One. 6:e251962011. View Article : Google Scholar : PubMed/NCBI
17	Das UN: Long-chain polyunsaturated fatty acids in growth and development of brain and memory. Nutrition. 19:62–65. 2003. View Article : Google Scholar
18	Fu ZY, Wang YP and Chen Y: Observation of insulin exocytosis by a pancreatic β cell line with total internal reflection fluorescence microscopy. Chin Med Sci J. 26:60–63. 2011.
19	Matsuyama M and Yoshimura R: Arachidonic acid pathway: A molecular target in human testicular cancer (Review). Mol Med Rep. 2:527–531. 2009.PubMed/NCBI
20	DeCostanzo AJ, Voloshyna I, Rosen ZB, et al: 12-Lipoxygenase regulates hippocampal long-term potentiation by modulating L-type Ca²⁺ channels. J Neurosci. 30:1822–1831. 2010. View Article : Google Scholar : PubMed/NCBI
21	Alescio-Lautier B and Soumireu-Mourat B: Role of vasopressin in learning and memory in the hippocampus. Prog Brain Res. 119:501–521. 1998. View Article : Google Scholar : PubMed/NCBI
22	Engelmann M, Wotjak CT, Ebner K and Landgraf R: Behavioral impact of intraseptally released vasopressin and oxytocin in rats. Exp Physiol. 85:S125–S130. 2000. View Article : Google Scholar : PubMed/NCBI