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Article

Therapeutic effect of compound of White Peony Root Oral Liquids on radiation-induced esophageal toxicity via the expression of EGF and TGF-β1

  • Authors:
    • Li Shen
    • Xing Li
    • Baoen Shan
    • Li Zhang
    • Yanjun Gong
    • Zhiming Dong
    • Zhiyu Wang
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, The First Hospital of the Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China, Department of Biotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Centre of Scientific Research, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Centre of HMO Administrator of Shijiazhuang, The First Hospital of the Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China
  • Pages: 308-314
    |
    Published online on: December 21, 2012
       https://doi.org/10.3892/br.2012.51
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Abstract

The predominant pathological processes of radiation‑induced esophageal toxicity include inflammatory reactions in the early stage and the fibrotic process in the late stage. An increased expression of the epidermal growth factor (EGF) and transforming growth factor β1 (TGF‑β1) is capable of reducing inflammatory reactions and TGF‑β1 is considered responsible for the initiation, development and persistence of fibrosis. In the present study, we investigated in vivo the therapeutic effect of the compound of white peony root oral liquids (cWPROL) on reducing the toxicity via modulating the expression levels of EGF and TGF‑β1. Adult male Wistar rats were treated and tissue sections were obtained. The tissue sections were stained using histological, Masson and immunohistochemical staining. The results revealed that cWPROL had a higher rate of repairing damaged structures compared with the control group. In addition, immunohistochemistry showed that although cWPROL and the mixture of lidocaine, dexamethasone and gentamycin (mLDG) induced levels of EGF and TGF‑β1 expression, there were differences between the two types of intervention. These results are significant for understanding that the mechanism of therapeutic effect of cWPROL varied to some extent from that of mLDG.
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1 

Bradley J and Movsas B: Radiation esophagitis: predictive factors and preventive strategies. Semin Radiat Oncol. 14:280–286. 2004. View Article : Google Scholar

2 

Byhardt RW, Scott C, Sause WT, et al: Response, toxicity, failure patterns and survival in five RTOG trails of sequential and/or concurrent chemotherapy and radiotherapy for locally advanced non-small-cell carcinoma of the lung. Int J Radiat Oncol Biol Phys. 42:469–478. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Abdel-Latif MM, Duggan S, Reynolds JV and Kelleher D: Inflammation and esophageal carcinogenesis. Curr Opin Pharmacol. 9:396–404. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Liu YF, Yu HM, Zhang C, Cheng YF, Hu LK, Meng XH and Zhao YX: Protective effects of berberine on radiation-induced lung injury via intercellular adhesion molecular-1 and transforming growth factor-beta-1 in patients with lung cancer. Eur J Cancer. 44:2425–2432. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Goodlad RA and Wright NA: Epidermal growth factor (EGF). Baillieres Clin Gastroenterology. 10:33–47. 1996. View Article : Google Scholar

6 

Fatimah SS, Tan GC, Chua KH, Tan AE and Hayati AR: Effects of epidermal growth factor on the proliferation and cell cycle regulation of cultured human amnion epithelial cells. J Biosci Bioeng. 114:220–227. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Pohlers D, Brenmoehl J, Löffler I, et al: TGF-beta and fibrosis in different organs - molecular pathway imprints. Biochim Biophys Acta. 1792:746–756. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Delanian S and Lefaix JL: The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway. Radiother Oncol. 73:119–131. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Barcellos-Hoff MH: How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues. Radiat Res. 150:109–120. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Martin M, Lefaix JL and Delanian S: TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target? Int J Radiat Oncol Biol Phys. 47:277–290. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Kosaka Y, Mitsumori M, Araki N, et al: Avascular necrosis of bilateral femoral head as a result of long-term steroid administration for radiation pneumonitis after tangential irradiation of the breast. Int J Clin Oncol. 11:482–486. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Hou W and Zhou YM: Function of traditional chinese medicine in cancer radiotherapy and its prospect. Mode Tradit Chin Med Mater Med. 11:742–746. 2009.

13 

Zhang P and Hu PL: TCM VVM Therapy’s influence on tumor patients’ survival. Chin J Oncol. 25:3022003.

14 

Shen L, Shan BE, Zhang L, et al: The experimental research of compound of White Pony Root Oral Liquid on radiation-induced esophagitis. J Radiol Prot. 27:219–227. 2007.

15 

Hallahan DE: Radiation-mediated gene expression in the pathogenesis of the clinical radiation response. Semin Radiat Oncol. 6:250–267. 1996. View Article : Google Scholar : PubMed/NCBI

16 

Somosy Z: Radiation response of cell organelles. Micron. 31:165–181. 2000. View Article : Google Scholar

17 

Falcieri E, Gobbi P, Zamai L and Vitale M: Ultrastructural features of apoptosis. Scan Microsc. 8:653–666. 2000.

18 

Payne CM, Bjore CG and Schultz DA: Change in the frequency of apoptosis after low- and high-dose X-irradiation of human lymphocytes. J Leukoc Biol. 52:433–440. 1992.PubMed/NCBI

19 

Barnard JA, Beauchamp RD, Russell WE, et al: Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology. 108:564–580. 1995. View Article : Google Scholar : PubMed/NCBI

20 

Garner A: Therapeutic potential of growth factors and their antagonists. Yale J Biol Med. 65:715–723. 1992.PubMed/NCBI

21 

Gibbs S, Silva Pinto AN, Murli S, Huber M, Hohl D and Ponec M: Epidermal growth factor and keratinocyte growth factor differentially regulate epidermal migration, growth, and differentiation. Wound Repair Regen. 8:192–203. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Reuter S, Gupta SC, Chaturvedi MM and Aggarwal B: Oxidative stress, inflammation, and cancer: How are they linked? Free Radical Bio Med. 49:1603–1616. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Rodemann HP and Marcel AB: Responses of normal cells to ionizing radiation. Semin Radiat Oncol. 17:81–88. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Fournier C, Scholz M, Kraft-Weyrather W, et al: Changes of fibrosis-related parameters after high- and low-LET irradiation of fibroblasts. Int J Radiat Biol. 77:713–722. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Rodemann HP and Bamberg M: Cellular basis of radiation-induced fibrosis. Radiother Oncol. 35:83–90. 1995. View Article : Google Scholar : PubMed/NCBI

26 

Border WA and Noble NA: Transforming growth factor beta in tissue fibrosis. N Engl J Med. 331:1286–1292. 1994. View Article : Google Scholar : PubMed/NCBI

27 

Schultze-Mosgau S, Blaese MA, Grabenbauer G, Wehrhan F, et al: Smad-3 and Smad-7 expression following antitransforming growth factor beta 1 (TGFbeta1)-treatment in irradiated rat tissue. Radiother Oncol. 70:249–259. 2004. View Article : Google Scholar : PubMed/NCBI

28 

McGinnis WL, Loprinzi CL, Buskirk SJ, et al: Placebo-controlled trail of sucralfate for inhibiting radiation-induced esophagitis. J Clin Oncol. 15:1239–1243. 1997.PubMed/NCBI

29 

Movsas B, Scott C, Langer C, et al: Phase III study of amifostine in patients with locally advanced non-small cell lung cancer (NSCLC) receiving chemotherapy and hyperfractionated radiation (Chemo/HFxRT): Radiation Therapy Oncology Group (RTOG) 98-01 (abstract 2559). Proc Am Soc Clin Oncol. 22:6362003.

30 

Steen VD, Medsger TA Jr and Rodnan GP: D-penicillamine therapy in progressive systemic sclerosis. Ann Intern Med. 97:652–659. 1982. View Article : Google Scholar : PubMed/NCBI

31 

Tsushima H, Kawata S, Tanura S, et al: Reduced plasma transforming growth factor-beta1 levels in patients with chronic hepatitis C after interferon alpha therapy: association with regression of hepatic fibrosis. J Hepatol. 30:1–7. 1999. View Article : Google Scholar

32 

Vozenin-Brotons MC, Sivan V, Gault N, et al: Anti-fibrotic action of Cu/Zn SOD is mediated by TGF-beta1 repression and phenotypic reversion of myofibroblasts. Free Radic Biol Med. 30:30–42. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shen L, Li X, Shan B, Zhang L, Gong Y, Dong Z and Wang Z: Therapeutic effect of compound of White Peony Root Oral Liquids on radiation-induced esophageal toxicity via the expression of EGF and TGF-β1. Biomed Rep 1: 308-314, 2013.
APA
Shen, L., Li, X., Shan, B., Zhang, L., Gong, Y., Dong, Z., & Wang, Z. (2013). Therapeutic effect of compound of White Peony Root Oral Liquids on radiation-induced esophageal toxicity via the expression of EGF and TGF-β1. Biomedical Reports, 1, 308-314. https://doi.org/10.3892/br.2012.51
MLA
Shen, L., Li, X., Shan, B., Zhang, L., Gong, Y., Dong, Z., Wang, Z."Therapeutic effect of compound of White Peony Root Oral Liquids on radiation-induced esophageal toxicity via the expression of EGF and TGF-β1". Biomedical Reports 1.2 (2013): 308-314.
Chicago
Shen, L., Li, X., Shan, B., Zhang, L., Gong, Y., Dong, Z., Wang, Z."Therapeutic effect of compound of White Peony Root Oral Liquids on radiation-induced esophageal toxicity via the expression of EGF and TGF-β1". Biomedical Reports 1, no. 2 (2013): 308-314. https://doi.org/10.3892/br.2012.51
Copy and paste a formatted citation
x
Spandidos Publications style
Shen L, Li X, Shan B, Zhang L, Gong Y, Dong Z and Wang Z: Therapeutic effect of compound of White Peony Root Oral Liquids on radiation-induced esophageal toxicity via the expression of EGF and TGF-β1. Biomed Rep 1: 308-314, 2013.
APA
Shen, L., Li, X., Shan, B., Zhang, L., Gong, Y., Dong, Z., & Wang, Z. (2013). Therapeutic effect of compound of White Peony Root Oral Liquids on radiation-induced esophageal toxicity via the expression of EGF and TGF-β1. Biomedical Reports, 1, 308-314. https://doi.org/10.3892/br.2012.51
MLA
Shen, L., Li, X., Shan, B., Zhang, L., Gong, Y., Dong, Z., Wang, Z."Therapeutic effect of compound of White Peony Root Oral Liquids on radiation-induced esophageal toxicity via the expression of EGF and TGF-β1". Biomedical Reports 1.2 (2013): 308-314.
Chicago
Shen, L., Li, X., Shan, B., Zhang, L., Gong, Y., Dong, Z., Wang, Z."Therapeutic effect of compound of White Peony Root Oral Liquids on radiation-induced esophageal toxicity via the expression of EGF and TGF-β1". Biomedical Reports 1, no. 2 (2013): 308-314. https://doi.org/10.3892/br.2012.51
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