Association between regulating synaptic membrane exocytosis 2 gene polymorphisms and degenerative lumbar scoliosis

Kim,Ki‑Tack; Lee,Jong Seok; Lee,Byoung Wook; Seok,Hosik; Jeon,Hye Sook; Kim,Jun Ho; Chung,Joo‑Ho

doi:10.3892/br.2013.101

July-August 2013 Volume 1 Issue 4

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July-August 2013 Volume 1 Issue 4

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Article

Association between regulating synaptic membrane exocytosis 2 gene polymorphisms and degenerative lumbar scoliosis

Authors:
- Ki‑Tack Kim
- Jong Seok Lee
- Byoung Wook Lee
- Hosik Seok
- Hye Sook Jeon
- Jun Ho Kim
- Joo‑Ho Chung
View Affiliations / Copyright

Affiliations: Department of Orthopedic Surgery, Spine Center, Kyung Hee University East‑West Neo Medical Center, Kangdong‑gu, Seoul 134‑090, Republic of Korea, Department of Emergency Medicine, Kyung Hee University, Dongdaemun‑gu, Seoul 130‑701, Republic of Korea, Department of Biochemistry and Molecular Biology, Kyung Hee University, Dongdaemun‑gu, Seoul 130‑701, Republic of Korea, Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Dongdaemun‑gu, Seoul 130‑701, Republic of Korea
Pages: 619-623
|
Published online on: May 9, 2013

https://doi.org/10.3892/br.2013.101
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Abstract

Degenerative lumbar scoliosis (DLS) is a spinal deformity that develops after skeletal maturity and progresses with age. In contrast to adolescent idiopathic scoliosis, the genetic association of DLS has not yet been elucidated. The purpose of this study was to investigate the association between regulating synaptic membrane exocytosis 2 (RIMS2, OBOE) gene polymorphisms and DLS. Two coding single‑nucleotide polymorphisms [rs2028945 (Gln1200Gln) and rs10461 (Ala1327Ala)] of RIMS2 were selected and genotyped by direct sequencing. As a result, the rs10461 was associated with DLS in allele frequencies (P=0.008) and genotype distributions (P=0.006 in the codominant model, 0.018 in the dominant model and 0.029 in the recessive model). In the analysis of haplotypes, two haplotypes exhibited significant differences between the control and DLS groups (CC haplotype, P=0.009 in the codominant model, 0.038 in the dominant model and 0.030 in the recessive model; CT haplotype, P=0.041 in the codominant model and 0.021 in the dominant model). These findings suggest that RIMS2 may be associated with the development of DLS.

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