Antiproliferative effects of protopanaxadiol ginsenosides on human colorectal cancer cells

Zheng,Yan; Nan,Hongmei; Hao,Miao; Song,Chengcheng; Zhou,Yifa; Gao,Yufei

doi:10.3892/br.2013.104

July-August 2013 Volume 1 Issue 4

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July-August 2013 Volume 1 Issue 4

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Article

Antiproliferative effects of protopanaxadiol ginsenosides on human colorectal cancer cells

Authors:
- Yan Zheng
- Hongmei Nan
- Miao Hao
- Chengcheng Song
- Yifa Zhou
- Yufei Gao
View Affiliations / Copyright

Affiliations: China‑Japan Union Hospital, Jilin University, Changchun, Jilin 130033, P.R. China, The First Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin 130021, P.R. China, School of Life Sciences, Northeast Normal University, Changchun, Jilin 130024, P.R. China
Pages: 555-558
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Published online on: May 10, 2013

https://doi.org/10.3892/br.2013.104
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Abstract

Ginsenosides are the main biologically active components of ginseng. In this study, seven types of protopanaxadiol ginsenosides were assessed for their antiproliferative activity on the HCT‑116 and HT‑29 human colorectal cancer cell lines using the 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide (MTT) assay. The experimental results indicated that the native protopanaxadiol ginsenosides Rb1 and Rb2 inhibited the proliferation of the colorectal cancer cells in a dose‑dependent manner. The deglycosylation products F2 and CO (from ginsenosides Rb1 and Rb2, respectively) significantly inhibited the growth of the human colorectal cancer cell lines, whereas product C‑K (from Rb1 and Rb2) exerted no antiproliferative effects on the cancer cell lines assessed in this study. HT‑29 cells were more sensitive to these ginsenosides compared to HCT‑116 cells. In addition, the antiproliferative activity of ginsenosides was found to be correlated with the number and type of sugar residues. The potent growth inhibitory effect of protopanaxadiol ginsenosides on cancer cells may be used in the pharmaceutical industry.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Antiproliferative effects of protopanaxadiol ginsenosides on human colorectal cancer cells

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