Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies

  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
July-August 2013 Volume 1 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-August 2013 Volume 1 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Early diagnosis of asparaginase‑associated pancreatitis based on elevated serum elastase‑1 levels: Case reports

  • Authors:
    • Tsuyoshi Morimoto
    • Kota Hirai
    • Akiko Fukumura
    • Hiromitsu Takakura
    • Takashi Koike
    • Takashi Shimizu

  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Tokai University School of Medicine, Isehara, Kanagawa 259‑1193, Japan
  • Pages: 651-653
    |
    Published online on: May 17, 2013
       https://doi.org/10.3892/br.2013.108
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

L‑asparaginase (L‑asp) is a well‑known anticancer agent used in the treatment of acute lymphoblastic leukemia (ALL) in children. However, it is also known to induce several acute complications, such as acute pancreatitis. This is a presentation of two pediatric acute lymphoblastic leukemia (ALL) cases of asparaginase‑associated pancreatitis (AAP) diagnosed at an early stage based on elevated serum elastase‑1 levels, in the presence of normal serum amylase levels. Early diagnosis and treatment of AAP, although imperative, is occasionally difficult if only standard diagnostic procedures are followed. Elastase‑1 is a potentially useful marker for the early diagnosis of AAP. Therefore, the measurement of elastase‑1 levels, in addition to amylase and lipase levels, is recommended in L‑asp‑treated patients.
View Figures

Figure 1

Figure 2

View References

1. 

Pui CH and Evans WE: Treatment of acute lymphoblastic leukemia. N Engl J Med. 354:166–178. 2006. View Article : Google Scholar : PubMed/NCBI

2. 

Land VJ, Sutow WW, Fernbach DJ, et al: Toxicity of L-asparaginase in children with advanced leukemia. Cancer. 30:339–347. 1972. View Article : Google Scholar : PubMed/NCBI

3. 

Sahu S, Saika S, Pai S and Advani SH: L-asparaginase (Leunase) induced pancreatitis in childhood acute lymphoblastic leukemia. Pediatr Hematol Oncol. 15:533–538. 1998. View Article : Google Scholar : PubMed/NCBI

4. 

Muller HJ and Boos J: Use of L-asparaginase in childhood ALL. Crit Rev Oncol Hematol. 28:97–113. 1998. View Article : Google Scholar : PubMed/NCBI

5. 

Knoderer HM, Robarge J and Flockhart DA: Predicting asparaginase-associated pancreatitis. Pediatr Blood Cancer. 49:634–639. 2007. View Article : Google Scholar

6. 

Raetz EA and Salzer WL: Tolerability and efficacy of L-asparaginase therapy in pediatric patients with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 32:554–563. 2010. View Article : Google Scholar : PubMed/NCBI

7. 

Raja RA, Schmiegelow K and Frandsen TL: Asparaginase-associated pancreatitis in children. Br J Haematol. 159:18–27. 2012. View Article : Google Scholar

8. 

Steinberg W and Tenner S: Acute pancreatitis. N Engl J Med. 330:1198–1210. 1994. View Article : Google Scholar : PubMed/NCBI

9. 

DeBanto JR, Goday PS, Pedroso MR, et al: Acute pancreatitis in children. Am J Gastroenterol. 97:1726–1731. 2002. View Article : Google Scholar : PubMed/NCBI

10. 

Silverman LB, Gelber RD, Dalton VK, et al: Improved outcome for children with acute lymphoblastic leukemia: results of the Dana-Farber Consortium Protocol 91-01. Blood. 97:1211–1218. 2001. View Article : Google Scholar : PubMed/NCBI

11. 

Treepongkaruna S, Thongpak N, Pakakasama S, et al: Acute pancreatitis in children with acute lymphoblastic leukemia after chemotherapy. J Pediatr Hematol Oncol. 31:812–815. 2009. View Article : Google Scholar : PubMed/NCBI

12. 

Yadav D, Agarwal N and Pitchumoni CS: A critical evaluation of laboratory tests in acute pancreatitis. Am J Gastroenterol. 97:1309–1318. 2002. View Article : Google Scholar : PubMed/NCBI

13. 

Treacy J, Williams A, Bais R, et al: Evaluation of amylase and lipase in the diagnosis of acute pancreatitis. ANZ J Surg. 71:577–582. 2001. View Article : Google Scholar : PubMed/NCBI

14. 

Satake K, Chung YS and Umeyama K: Serum elastase 1 levels in pancreatic disease. Am J Surg. 144:239–242. 1982. View Article : Google Scholar

15. 

Gullo L, Ventrucci M, Pezzilli R, et al: Diagnositic value of serum elastase 1 in pancreatic disease. Br J Surg. 74:44–47. 1987. View Article : Google Scholar : PubMed/NCBI

16. 

Büchler M, Malfertheiner P, Uhl W and Beger HG: Diagnostic and prognostic value of serum elastase 1 in acute pancreatitis. Klin Wochenschr. 64:1186–1191. 1986.PubMed/NCBI

17. 

Millson CE, Charles K, Poon P, et al: A prospective study of serum pancreatic elastase-1 in the diagnosis and assessment of acute pancreatitis. Scand J Gastroenterol. 33:664–668. 1998. View Article : Google Scholar : PubMed/NCBI

18. 

Flamion B, Delhaye M, Horanyi Z, et al: Comparison of elastase-1 with amylase, lipase, and trypsin-like immunoreactivity in the diagnosis of acute pancreatitis. Am J Gastroenterol. 82:532–535. 1987.PubMed/NCBI

19. 

Shimizu T, Yamashiro Y, Igarashi J, et al: Increased serum trypsin and elastase-1 levels in patients undergoing L-asparaginase therapy. Eur J Pediatr. 157:561–563. 1998. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Morimoto T, Hirai K, Fukumura A, Takakura H, Koike T and Shimizu T: Early diagnosis of asparaginase‑associated pancreatitis based on elevated serum elastase‑1 levels: Case reports. Biomed Rep 1: 651-653, 2013.
APA
Morimoto, T., Hirai, K., Fukumura, A., Takakura, H., Koike, T., & Shimizu, T. (2013). Early diagnosis of asparaginase‑associated pancreatitis based on elevated serum elastase‑1 levels: Case reports. Biomedical Reports, 1, 651-653. https://doi.org/10.3892/br.2013.108
MLA
Morimoto, T., Hirai, K., Fukumura, A., Takakura, H., Koike, T., Shimizu, T."Early diagnosis of asparaginase‑associated pancreatitis based on elevated serum elastase‑1 levels: Case reports". Biomedical Reports 1.4 (2013): 651-653.
Chicago
Morimoto, T., Hirai, K., Fukumura, A., Takakura, H., Koike, T., Shimizu, T."Early diagnosis of asparaginase‑associated pancreatitis based on elevated serum elastase‑1 levels: Case reports". Biomedical Reports 1, no. 4 (2013): 651-653. https://doi.org/10.3892/br.2013.108
Copy and paste a formatted citation
x
Spandidos Publications style
Morimoto T, Hirai K, Fukumura A, Takakura H, Koike T and Shimizu T: Early diagnosis of asparaginase‑associated pancreatitis based on elevated serum elastase‑1 levels: Case reports. Biomed Rep 1: 651-653, 2013.
APA
Morimoto, T., Hirai, K., Fukumura, A., Takakura, H., Koike, T., & Shimizu, T. (2013). Early diagnosis of asparaginase‑associated pancreatitis based on elevated serum elastase‑1 levels: Case reports. Biomedical Reports, 1, 651-653. https://doi.org/10.3892/br.2013.108
MLA
Morimoto, T., Hirai, K., Fukumura, A., Takakura, H., Koike, T., Shimizu, T."Early diagnosis of asparaginase‑associated pancreatitis based on elevated serum elastase‑1 levels: Case reports". Biomedical Reports 1.4 (2013): 651-653.
Chicago
Morimoto, T., Hirai, K., Fukumura, A., Takakura, H., Koike, T., Shimizu, T."Early diagnosis of asparaginase‑associated pancreatitis based on elevated serum elastase‑1 levels: Case reports". Biomedical Reports 1, no. 4 (2013): 651-653. https://doi.org/10.3892/br.2013.108
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team