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Article

Identification of sequence polymorphisms in the displacement loop region of mitochondrial DNA as a risk factor for renal cell carcinoma

  • Authors:
    • Junxia Zhang
    • Zhanjun Guo
    • Yaling Bai
    • Liwen Cui
    • Shenglei Zhang
    • Jinsheng Xu
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
  • Pages: 563-566
    |
    Published online on: May 22, 2013
       https://doi.org/10.3892/br.2013.113
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Abstract

The accumulation of single‑nucleotide polymorphisms (SNPs) in the displacement loop (D‑loop) of mitochondrial DNA (mtDNA) may be associated with an increased cancer risk. in this case‑control study, the SNPs in the mitochondrial D‑loop of renal cell carcinoma (RCC) patients were identified and their association with cancer risk was evaluated. The minor alleles of nucleotides 16293A̸G, 262A̸G and 488T̸C were associated with an increased risk, whereas the minor alleles of nucleotides 16298T̸C and 16319G̸A were associated with a decreased risk for RCC. Moreover, the nucleotides 16293, 262, 16298 and 16319 were identified as specifically associated with the risk of clear cell RCC (ccRCC), whereas 262 and 488 were specifically associated with papillary RCC and renal oncocytoma. In conclusion, SNPs in mtDNA are potential modifiers of RCC. The analysis of genetic polymorphisms in the mitochondrial D‑loop may help identify the patient subgroups at a high risk of developing RCC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Guo Z, Bai Y, Cui L, Zhang S and Xu J: Identification of sequence polymorphisms in the displacement loop region of mitochondrial DNA as a risk factor for renal cell carcinoma. Biomed Rep 1: 563-566, 2013.
APA
Zhang, J., Guo, Z., Bai, Y., Cui, L., Zhang, S., & Xu, J. (2013). Identification of sequence polymorphisms in the displacement loop region of mitochondrial DNA as a risk factor for renal cell carcinoma. Biomedical Reports, 1, 563-566. https://doi.org/10.3892/br.2013.113
MLA
Zhang, J., Guo, Z., Bai, Y., Cui, L., Zhang, S., Xu, J."Identification of sequence polymorphisms in the displacement loop region of mitochondrial DNA as a risk factor for renal cell carcinoma". Biomedical Reports 1.4 (2013): 563-566.
Chicago
Zhang, J., Guo, Z., Bai, Y., Cui, L., Zhang, S., Xu, J."Identification of sequence polymorphisms in the displacement loop region of mitochondrial DNA as a risk factor for renal cell carcinoma". Biomedical Reports 1, no. 4 (2013): 563-566. https://doi.org/10.3892/br.2013.113
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Guo Z, Bai Y, Cui L, Zhang S and Xu J: Identification of sequence polymorphisms in the displacement loop region of mitochondrial DNA as a risk factor for renal cell carcinoma. Biomed Rep 1: 563-566, 2013.
APA
Zhang, J., Guo, Z., Bai, Y., Cui, L., Zhang, S., & Xu, J. (2013). Identification of sequence polymorphisms in the displacement loop region of mitochondrial DNA as a risk factor for renal cell carcinoma. Biomedical Reports, 1, 563-566. https://doi.org/10.3892/br.2013.113
MLA
Zhang, J., Guo, Z., Bai, Y., Cui, L., Zhang, S., Xu, J."Identification of sequence polymorphisms in the displacement loop region of mitochondrial DNA as a risk factor for renal cell carcinoma". Biomedical Reports 1.4 (2013): 563-566.
Chicago
Zhang, J., Guo, Z., Bai, Y., Cui, L., Zhang, S., Xu, J."Identification of sequence polymorphisms in the displacement loop region of mitochondrial DNA as a risk factor for renal cell carcinoma". Biomedical Reports 1, no. 4 (2013): 563-566. https://doi.org/10.3892/br.2013.113
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