Association of annexin A5 polymorphisms with obesity

Seok,Hosik; Park,Hae   Jeong; Lee,Byoung  Wook; Kim,Jong  Woo; Jung,Min; Lee,Seo  Ra; Park,Ki  Ho; Park,Young  Guk; Baik,Hyung  Hwan; Chung,Joo‑Ho

doi:10.3892/br.2013.118

July-August 2013 Volume 1 Issue 4

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July-August 2013 Volume 1 Issue 4

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Article

Association of annexin A5 polymorphisms with obesity

Authors:
- Hosik Seok
- Hae Jeong Park
- Byoung Wook Lee
- Jong Woo Kim
- Min Jung
- Seo Ra Lee
- Ki Ho Park
- Young Guk Park
- Hyung Hwan Baik
- Joo‑Ho Chung
View Affiliations / Copyright

Affiliations: Department of Pharmacology and Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea, Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea, Department of Neuropsychiatry, School of Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea, Department of Orthodontics, School of Dentistry, Kyung Hee University, Seoul 130‑701, Republic of Korea
Pages: 654-658
|
Published online on: May 29, 2013

https://doi.org/10.3892/br.2013.118
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Abstract

Annexin A5 (ANXA5), which is known as a protein with anticoagulative function, may play a role in triglyceride biosynthesis. Triglycerides are involved in lipid and energy metabolism, which are important in the elucidation of obesity. To investigate the association between single‑nucleotide polymorphisms (SNPs) of ANXA5 and obesity in a Korean population, 372 participants (213 overweight/obese individuals and 159 control subjects) were enrolled from the Kyung Hee University Medical Center and Keimyung University Dongsan Medical Center. the genotypes of five SNPs (rs12510548, rs4240260, rs3756281, rs13136094 and rs6534313) were evaluated in ANXA5 using the multiple logistic regression analysis with the codominant 1, codominant 2, dominant, recessive and log‑additive models. The genotype and allele frequencies of the five investigated SNPs exhibited significant differences between the control and the overweight/obese groups: rs12510548 (P=0.004 in the codominant 2 model, P=0.0019 in the recessive model, P=0.027 in the log‑additive model and P=0.026 in allele frequencies); rs4240260 (P=0.002 and Fisher's exact P=0.0006 in the codominant 2 model, P=0.0007 and Fisher's exact P=0.0007 in the recessive model, P=0.020 and Fisher's exact P=0.0019 in the log‑additive model and P=0.020 in allele frequencies); rs3756281 (P=0.016 in the codominant 2 model and P=0.0094 in the recessive model); rs13136094 (P=0.0030 and Fisher's exact P=0.0011 in the codominant 2 model, P=0.0012 and Fisher's exact P=0.0013 in the recessive model, P=0.034 and Fisher's exact P=0.0035 in the log‑additive model and P=0.024 in allele frequencies); and rs6534313 (P=0.0010 and Fisher's exact P=0.0003 in the codominant 2 model, P=0.0003 and Fisher's exact P=0.0003 in the recessive model, P=0.0075 and Fisher's exact P=0.0010 in the log‑additive model and P=0.005 in allele frequencies). Two haplotypes were weakly associated with obesity (GGATG, P=0.037 and CAGCC, P=0.020). Results of the present study suggested that ANXA5 may be associated with the development of obesity in a Korean population.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Association of annexin A5 polymorphisms with obesity

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Abstract

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