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Print ISSN: 2049-9434 Online ISSN: 2049-9442
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July-August 2013 Volume 1 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Preliminary study on XAGE-1b gene and its mechanism for promoting tumor cell growth

  • Authors:
    • Bo Zhou
    • Tingxiu Li
    • Yang Liu
    • Naishuo Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Gerontology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu 210009, P.R. China, Department of Chemotherapy, Cancer Hospital, Guangxi Medical University, Nanning, Guangxi 530000, P.R. China, Laboratory of Molecular Virology and Immunology, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China
  • Pages: 567-572
    |
    Published online on: May 30, 2013
       https://doi.org/10.3892/br.2013.122
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Abstract

The XAGE-1b gene has been identified in numerous malignancies in the human body. However, little is known regarding its mechanism for promoting tumorigenesis in adenoid cystic carcinoma. The aim of this study was to explore the correlation between tumor cell growth and the XAGE-1b gene. The constructed PCMV‑Myc plasmid vector containing the XAGE-1b gene and transfected adenoid cystic carcinoma (ACC)‑2 cells was applied to study cell cycle alterations and anti‑apoptotic effects. These were assessed by flow cytometry with PI staining and the measurement of cell content at its Sub‑G1 phase, respectively. The fluorescence intensity representing the regulation of XAGE-1b on the transcription factors located downstream of the signaling pathway using the Mercury pathway profiling system was also detected. XAGE‑1b over­expression promoted cell growth by shortening G0-G1 and prolonging the G2-M phase. Additionally, XAGE‑1b overexpression enhanced the anti‑apoptotic effects induced by tumor necrosis factor-α (TNF-α) and serum deprivation in ACC‑2 cells. The results of the present study suggested that XAGE‑1b gene is crucial in the tumorigenesis of ACC, and its mechanism should be further investigated.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou B, Li T, Liu Y and Zhu N: Preliminary study on XAGE-1b gene and its mechanism for promoting tumor cell growth. Biomed Rep 1: 567-572, 2013.
APA
Zhou, B., Li, T., Liu, Y., & Zhu, N. (2013). Preliminary study on XAGE-1b gene and its mechanism for promoting tumor cell growth. Biomedical Reports, 1, 567-572. https://doi.org/10.3892/br.2013.122
MLA
Zhou, B., Li, T., Liu, Y., Zhu, N."Preliminary study on XAGE-1b gene and its mechanism for promoting tumor cell growth". Biomedical Reports 1.4 (2013): 567-572.
Chicago
Zhou, B., Li, T., Liu, Y., Zhu, N."Preliminary study on XAGE-1b gene and its mechanism for promoting tumor cell growth". Biomedical Reports 1, no. 4 (2013): 567-572. https://doi.org/10.3892/br.2013.122
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou B, Li T, Liu Y and Zhu N: Preliminary study on XAGE-1b gene and its mechanism for promoting tumor cell growth. Biomed Rep 1: 567-572, 2013.
APA
Zhou, B., Li, T., Liu, Y., & Zhu, N. (2013). Preliminary study on XAGE-1b gene and its mechanism for promoting tumor cell growth. Biomedical Reports, 1, 567-572. https://doi.org/10.3892/br.2013.122
MLA
Zhou, B., Li, T., Liu, Y., Zhu, N."Preliminary study on XAGE-1b gene and its mechanism for promoting tumor cell growth". Biomedical Reports 1.4 (2013): 567-572.
Chicago
Zhou, B., Li, T., Liu, Y., Zhu, N."Preliminary study on XAGE-1b gene and its mechanism for promoting tumor cell growth". Biomedical Reports 1, no. 4 (2013): 567-572. https://doi.org/10.3892/br.2013.122
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