Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
July-August 2013 Volume 1 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-August 2013 Volume 1 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Susceptibility of XPD and hOGG1 genetic variants to prostate cancer

  • Authors:
    • Cheng Zhou
    • Li‑Ping Xie
    • Yi‑Wei Lin
    • Kai Yang
    • Qi‑Qi Mao
    • Yue Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Ningbo First Hospital, Ningbo, Zhejiang 315000, P.R. China, Department of Urology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China
  • Pages: 679-683
    |
    Published online on: May 30, 2013
       https://doi.org/10.3892/br.2013.123
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

DNA repair genes are important in maintaining genomic stability and integrity. DNA repair gene polymorphisms, such as those of the human homolog of 8‑oxoguanine DNA glycosylase 1 (hOGG1) and excision repair cross‑complementing rodent repair deficiency, complementation group 2̸Xeroderma pigmentosum complementation group D (ERCC2̸XPD), contribute to carcinogenesis. The aim of this study was to investigate the association of prostate cancer (PCa) risk with hOGG1 and ERCC2̸XPD genetic variants. A case‑control study of 200 cases including 100 PCa patients and 100 healthy subjects was conducted. Two single‑nucleotide polymorphisms (SNPs) (ERCC2/XPD Arg156Arg and hOGG1 Ser326Cys) were genotyped by polymerase chain reaction‑restriction fragment length polymorphism (PCR‑RFLP). The results demonstrated a significant association of the XPD156 homozygous (AA, OR=3.80; 95% CI: 1.19‑12.18; P=0.017), heterozygous (AC, OR=2.48; 95% CI: 1.02‑6.35; P=0.033) and combined (AA+AC, OR=2.76; 95% CI: 1.18‑6.84; P=0.011) mutant genotypes with a predisposition to high‑risk PCa. In the stratified analysis, predisposition to high‑risk PCa was also associated with the mutant genotypes of hOGG1 326 homozygous mutant (GG, OR=2.93; 95% CI: 1‑8.74; P=0.033). The results also showed that the A allele of XPD Arg156Arg and the G allele of hOGG1 Ser326Cys were associated with an increased risk of PCa (OR=1.86 and 1.62; 95% CI: 1.13‑3.06 and 1‑2.67, respectively). In conclusion, the findings of this study demonstrated that the ERCC2/XPD Arg156Arg and hOGG1 Ser326Cys polymorphisms increased the susceptibility to high‑risk PCa.
View Figures

Figure 1

Figure 2

View References

1 

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer statistics, 2008. CA Cancer J Clin. 58:71–96. 2008. View Article : Google Scholar

2 

McCracken M, Olsen M, Chen MS Jr, Jemal A, Thun M, Cokkinides V, Deapen D and Ward E: Cancer incidence, mortality, and associated risk factors among Asian Americans of Chinese, Filipino, Vietnamese, Korean, and Japanese ethnicities. CA Cancer J Clin. 57:190–205. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Pienta KJ and Esper PS: Risk factors for prostate cancer. Ann Intern Med. 118:793–803. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Chan JM, Holick CN, Leitzmann MF, et al: Diet after diagnosis and the risk of prostate cancer progression, recurrence, and death (United States). Cancer Causes Control. 17:199–208. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Vogel U, Olsen A, Wallin H, Overvad K, Tjonneland A and Nexo BA: Effect of polymorphisms in XPD, RAI, ASE-1 and ERCC1 on the risk of basal cell carcinoma among Caucasians after age 50. Cancer Detect Prev. 29:209–214. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Thompson LH and West MG: XRCC1 keeps DNA from getting stranded. Mutat Res. 459:1–18. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Sancar A and Tang MS: Nucleotide excision repair. Photochem Photobiol. 57:905–921. 1993. View Article : Google Scholar

8 

Ishikawa T, Zhang SS, Qin X, et al: DNA repair and cancer: lessons from mutant mouse models. Cancer Sci. 95:112–117. 1993. View Article : Google Scholar

9 

Terry MB, Gammon MD, Zhang FF, Eng SM, Sagiv SK, Paykin AB, Wang Q, Hayes S, Teitelbaum SL, Neugut AI and Santella RM: Polymorphism in the DNA repair gene XPD, polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 13:2053–2058. 2004.PubMed/NCBI

10 

Goode EL, Ulrich CM and Potter JD: Polymorphisms in DNA repair gene and associations with cancer risk. Cancer Epidemiol Biomarkers Prev. 11:1513–1530. 2002.PubMed/NCBI

11 

Xing D, Tan W and Lin D: Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (Review). Oncol Rep. 10:1615–1623. 2003.PubMed/NCBI

12 

Park J, Chen L, Tockman MS, Elahi A and Lazarus P: The human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) DNA repair enzyme and its association with lung cancer risk. Pharmacogenetics. 14:103–109. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Kim JI, Park YJ, Kim KH, Kim JI, Song BJ, Lee MS, Kim CN and Chang SH: hOGG1 Ser326Cys polymorphism modifies the significance of the environmental risk factor for colon cancer. World J Gastroenterol. 9:956–960. 2003.PubMed/NCBI

14 

Song FJ, Zhang BL, He M, et al: Trend analysis of the incidence of prostate cancer in Tianjin between 1981 and 2004. Zhong hua Yi Xue Za Zhi. 90:2811–2814. 2010.(In Chinese).

15 

Zheng SL, Sun J, Wiklund F, et al: Cumulative association of five genetic variants with prostate cancer. N Engl J Med. 358:910–919. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Heidenreich A, Aus G, Bolla M, et al: Guidelines on Prostate Cancer. European Association of Urology (EAU); Arnhem, The Netherlands: 2010

17 

Yuan H, Niu YM, Wang RX, Li HZ and Chen N: Association between XPD Lys751Gln polymorphism and risk of head and neck cancer: a meta-analysis. Genet Mol Res. 22:3356–3364. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Ding DP, Ma WL, He XF and Zhang Y: XPD Lys751Gln polymorphism and esophageal cancer susceptibility: a meta-analysis of case-control studies. Mol Biol Rep. 39:2533–2540. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Vogel U, Nexo BA, Tjonneland A, et al: ERCC1, XPD and RAI mRNA levels in lymphocytes are not associated with lung cancer risk in a prospective study of Danes. Mutat Res. 593:88–96. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Wu W, Zhang W, Qiao R, et al: Association of XPD polymorphisms with severe toxicity in non-small cell lung cancer patients in a Chinese population. Clin Cancer Res. 15:3889–3895. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Shao J, Gu M, Xu Z, et al: Polymorphisms of the DNA gene XPD and risk of bladder cancer in a Southeastern Chinese population. Cancer Genet Cytogenet. 177:30–36. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Yin J, Liang D, Vogel U, et al: The polymorphism of DNA repair gene ERCC2/XPD Arg156Arg and susceptibility to breast cancer in a Chinese population. Biochem Genet. 47:582–590. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Guan P, Huang D, Yin Z and Zhou B: Association of the hOGG1 Ser326Cys polymorphism with increased lung cancer susceptibility in Asians: a meta-analysis of 18 studies including 7592 cases and 8129 controls. Asian Pac J Cancer Prev. 12:1067–1072. 2011.PubMed/NCBI

24 

Ni M, Qiu J, He W and Wang X: The functional Ser326Cys polymorphism in hOGG1 is associated with gastric cancer risk: evidence from 1180 cases and 2444 controls. Eur J Gastroenterol Hepatol. 24:683–687. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Srivastava K, Srivastava A and Mittal B: Polymorphisms in ERCC2, MSH2, and OGG1 DNA repair genes and gallbladder cancer risk in a population of Northern India. Cancer. 116:3160–3169. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Arizono K, Osada Y and Kuroda Y: DNA repair gene hOGG1 codon 326 and XRCC1 codon 399 polymorphisms and bladder cancer risk in a Japanese population. Jpn J Clin Oncol. 38:186–191. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Okasaka T, Matsuo K, Suzuki T, et al: hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type. J Hum Genet. 54:739–745. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Li H, Hao X and Zhang W: The hOGG1 Ser326Cys polymorphism and lung cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 17:1739–1745. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Xu J, Zheng SL, Turner A, et al: Associations between hOGG1 sequence variants and prostate cancer susceptibility. Cancer Res. 62:2253–2257. 2002.PubMed/NCBI

30 

Zhang J, Dhakal IB, Greene G, Lang NP and Kadlubar FF: Polymorphisms in hOGG1 and XRCC1 and risk of prostate cancer: effects modified by plasma antioxidants. Urology. 75:779–785. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Nam RK, Zhang WW, Jewett MA, et al: The use of genetic markers to determine risk for prostate cancer at prostate biopsy. Clin Cancer Res. 11:8391–8397. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Chen L, Elahi A, Pow-Sang J, Lazarus P and Park J: Association between polymorphism of human oxoguanine glycosylase 1 and risk of prostate cancer. J Urol. 170(6 Pt 1): 2471–2474. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhou C, Xie LP, Lin YW, Yang K, Mao QQ and Cheng Y: Susceptibility of XPD and hOGG1 genetic variants to prostate cancer. Biomed Rep 1: 679-683, 2013.
APA
Zhou, C., Xie, L., Lin, Y., Yang, K., Mao, Q., & Cheng, Y. (2013). Susceptibility of XPD and hOGG1 genetic variants to prostate cancer. Biomedical Reports, 1, 679-683. https://doi.org/10.3892/br.2013.123
MLA
Zhou, C., Xie, L., Lin, Y., Yang, K., Mao, Q., Cheng, Y."Susceptibility of XPD and hOGG1 genetic variants to prostate cancer". Biomedical Reports 1.4 (2013): 679-683.
Chicago
Zhou, C., Xie, L., Lin, Y., Yang, K., Mao, Q., Cheng, Y."Susceptibility of XPD and hOGG1 genetic variants to prostate cancer". Biomedical Reports 1, no. 4 (2013): 679-683. https://doi.org/10.3892/br.2013.123
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou C, Xie LP, Lin YW, Yang K, Mao QQ and Cheng Y: Susceptibility of XPD and hOGG1 genetic variants to prostate cancer. Biomed Rep 1: 679-683, 2013.
APA
Zhou, C., Xie, L., Lin, Y., Yang, K., Mao, Q., & Cheng, Y. (2013). Susceptibility of XPD and hOGG1 genetic variants to prostate cancer. Biomedical Reports, 1, 679-683. https://doi.org/10.3892/br.2013.123
MLA
Zhou, C., Xie, L., Lin, Y., Yang, K., Mao, Q., Cheng, Y."Susceptibility of XPD and hOGG1 genetic variants to prostate cancer". Biomedical Reports 1.4 (2013): 679-683.
Chicago
Zhou, C., Xie, L., Lin, Y., Yang, K., Mao, Q., Cheng, Y."Susceptibility of XPD and hOGG1 genetic variants to prostate cancer". Biomedical Reports 1, no. 4 (2013): 679-683. https://doi.org/10.3892/br.2013.123
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team