Analysis of the risk factors for influenza A (H1N1) pneumonia

Zhang,Qing; Zhao,Zhi‑Wei; Xing,Zhi‑Li; Zhang,Bo; Zheng,Hong‑Fei; Sun,Li‑Xin

doi:10.3892/br.2013.128

September-October 2013 Volume 1 Issue 5

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September-October 2013 Volume 1 Issue 5

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Article

Analysis of the risk factors for influenza A (H1N1) pneumonia

Authors:
- Qing Zhang
- Zhi‑Wei Zhao
- Zhi‑Li Xing
- Bo Zhang
- Hong‑Fei Zheng
- Li‑Xin Sun
View Affiliations / Copyright

Affiliations: Department of Respiratory Disease, The Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, P.R. China, Department of Emergency, The Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, P.R. China, Central Laboratory, The Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, P.R. China
Pages: 723-726
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Published online on: June 3, 2013

https://doi.org/10.3892/br.2013.128
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Abstract

Pneumonia is the most common complication of influenza A (H1N1). However, there has been no identification of any single initial symptom as an independent risk factor. in 2009, 206 patients were diagnosed with H1N1 in the Chengde area, China and they were assembled in the Chengde Hospital for Infectious Diseases. The diagnosis and treatment were performed in accordance with the Protocol for Diagnosis and Treatment of Influenza A (H1N1) (2009, third edition), issued by the General Office of the Ministry of Health, with detailed records by the medical staff assigned by the Bureau of Health of the Chengde government. all the patients had viral nucleic acid‑positive throat swabs detected with quantitative reverse transcription polymerase chain reaction (qPCR). Based on the final imaging findings, patients were divided into the pneumonia and non‑pneumonia groups for this case control study. The univariate analysis demonstrated that the ratios of patients aged 0‑5 and ≥45 years, with underlying diseases, with initial symptoms including cough, expectoration and dyspnea and with onset‑to‑treatment interval of >48 h were higher in the pneumonia compared to the non‑pneumonia group (P<0.001, P<0.001, P=0.018, P<0.001, P<0.001 and P<0.001, respectively). The multivariate logistic regression analysis demonstrated that age 0‑5 years, presence of underlying diseases, expectoration as the initial symptom and onset‑to‑treatment interval of >48 h were the independent risk factors for pneumonia with relative odds ratios (OR) and 95% confidence intervals (95% CIs) of 6.120 and 1.779‑21.088, 11.188 and 2.021‑61.935, 5.263 and 2.042‑13.562, and 22.873 and 6.110‑85.631, respectively (P<0.01). Therefore, it is recommended that patients with H1N1 presenting with expectoration as the initial symptom be treated with caution during influenza pandemics.

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1	No authors listed. New influenza A (H1N1) virus: global epidemiological situation. June;2009. Wkly Epidemiol Rec. 84:249–257. 2009.PubMed/NCBI
2	Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic (H1N1) 2009 Influenza. Bautista E, Chotpitayasunondh T, Gao Z, Harper SA, Shaw M, Uyeki TM, Zaki SR, Hayden FG, Hui DS, Kettner JD, Kumar A, Lim M, Shindo N, Penn C and Nicholson KG: Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. N Engl J Med. 362:1708–1719. 2010. View Article : Google Scholar : PubMed/NCBI
3	World Health Organization. Pandemic (H1N1) 2009-update 112 [EB/OL]. http://www.who.int/csr/don/2010_08_06/en/uri. Accessed October 13, 2009
4	General Office of the Ministry of Health. Program of diagnosis and treatment of influenza A H1N1 (Version III, 2009) [EB/OL]. http://news.xinhuanet.com/health/2009-11/11/content_12431885_3.htmuri. Accessed October 13, 2009(In Chinese).
5	Trifonov V, Khiabanian H and Rabadan R: Geographic dependence, surveillance, and origins of the 2009 influenza A (H1N1) virus. N Engl J Med. 361:115–119. 2009. View Article : Google Scholar : PubMed/NCBI
6	Hancock K, Veguilla V, Lu X, Zhong W, Butler EN, et al: Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus. N Engl J Med. 361:1945–1952. 2009. View Article : Google Scholar : PubMed/NCBI
7	Webb SA, Pettilä V, Seppelt I, et al; ANZIC Influenza Investigators. Critical care services and 2009 H1N1 influenza in Australia and New Zealand. N Engl J Med. 361:1925–1934. 2009. View Article : Google Scholar : PubMed/NCBI
8	Kumar A, Zarychanski R, Pinto R, et al: Critically ill patients with 2009 influenza A (H1N1) infection in Canada. JAMA. 302:1872–1879. 2009. View Article : Google Scholar : PubMed/NCBI
9	Louie JK, Aeosta M, Willter K, et al: Factors associated with death or hospitalization due to pandemic 2009 influenza A (H1N1) infection in Califomia. JAMA. 302:1896–1902. 2009. View Article : Google Scholar : PubMed/NCBI
10	Van Kerkhove MD, Vandemaele KA, Shinde V, Jaramillo-Gutierrez G, Koukounari A, et al: Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis. PLoS Med. 8:e10010532011.PubMed/NCBI
11	Jain S, Kamimoto L, Bramley AM, Schmitz AM, Benoit SR, et al: Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009. N Engl J Med. 361:1935–1944. 2009. View Article : Google Scholar : PubMed/NCBI
12	Echevarría Zuno S, Mejía-Aranguré JM, Mar-Obeso AJ, et al: Infection and death from influenza A H1N1 virus in Mexico: a retrospective analysis. Lancet. 374:2072–2079. 2009.PubMed/NCBI
13	Higuera Iglesias AL, Kudo K, Manabe T, Corcho Berdugo AE, Corrales Baeza AC, et al: Reducing occurrence and severity of pneumonia due to pandemic H1N1 2009 by early oseltamivir administration: a retrospective study in Mexico. PLoS One. 6:e218382011.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Analysis of the risk factors for influenza A (H1N1) pneumonia

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