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Article

A/G polymorphism of matrix metalloproteinase 7 gene promoter region and cancer risk: A meta‑analysis

  • Authors:
    • Jin Wu
    • Xuan Guan
    • Kui Zhang
    • Ya‑Ting Li
    • Peng Bai
  • View Affiliations / Copyright

    Affiliations: Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China, School of Basic Medical Sciences, Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China, Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 792-796
    |
    Published online on: July 11, 2013
       https://doi.org/10.3892/br.2013.131
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Abstract

This meta‑analysis was conducted to evaluate the effect of the matrix metalloproteinase 7 (MMP7)‑181A/G polymorphism on cancer risk. Twenty‑seven case‑control studies were identified via a literature search through PubMed, web of science and China National Knowledge Infrastructure databases. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were applied to assess the strength of the association between MMP7‑181A/G polymorphism and cancer risk. The 27 studies were further assessed according to Hardy‑Weinberg equilibrium (HWE) and Hardy‑Weinberg disequilibrium (HWD), with 24 case‑control studies found to be under HWE. A significant association was observed between MMP7‑181A̸G polymorphism and increased cancer risk (cervical and other types of cancer) in Asian, but not in European populations.
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Copy and paste a formatted citation
Spandidos Publications style
Wu J, Guan X, Zhang K, Li YT and Bai P: A/G polymorphism of matrix metalloproteinase 7 gene promoter region and cancer risk: A meta‑analysis. Biomed Rep 1: 792-796, 2013.
APA
Wu, J., Guan, X., Zhang, K., Li, Y., & Bai, P. (2013). A/G polymorphism of matrix metalloproteinase 7 gene promoter region and cancer risk: A meta‑analysis. Biomedical Reports, 1, 792-796. https://doi.org/10.3892/br.2013.131
MLA
Wu, J., Guan, X., Zhang, K., Li, Y., Bai, P."A/G polymorphism of matrix metalloproteinase 7 gene promoter region and cancer risk: A meta‑analysis". Biomedical Reports 1.5 (2013): 792-796.
Chicago
Wu, J., Guan, X., Zhang, K., Li, Y., Bai, P."A/G polymorphism of matrix metalloproteinase 7 gene promoter region and cancer risk: A meta‑analysis". Biomedical Reports 1, no. 5 (2013): 792-796. https://doi.org/10.3892/br.2013.131
Copy and paste a formatted citation
x
Spandidos Publications style
Wu J, Guan X, Zhang K, Li YT and Bai P: A/G polymorphism of matrix metalloproteinase 7 gene promoter region and cancer risk: A meta‑analysis. Biomed Rep 1: 792-796, 2013.
APA
Wu, J., Guan, X., Zhang, K., Li, Y., & Bai, P. (2013). A/G polymorphism of matrix metalloproteinase 7 gene promoter region and cancer risk: A meta‑analysis. Biomedical Reports, 1, 792-796. https://doi.org/10.3892/br.2013.131
MLA
Wu, J., Guan, X., Zhang, K., Li, Y., Bai, P."A/G polymorphism of matrix metalloproteinase 7 gene promoter region and cancer risk: A meta‑analysis". Biomedical Reports 1.5 (2013): 792-796.
Chicago
Wu, J., Guan, X., Zhang, K., Li, Y., Bai, P."A/G polymorphism of matrix metalloproteinase 7 gene promoter region and cancer risk: A meta‑analysis". Biomedical Reports 1, no. 5 (2013): 792-796. https://doi.org/10.3892/br.2013.131
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