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Review

Interleukin‑13 and its receptors in colorectal cancer (Review)

  • Authors:
    • Ru Zhou
    • Shiguang Qian
    • Xiaodong Gu
    • Zongyou Chen
    • Jianbin Xiang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Immunology and General Surgery, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
  • Pages: 687-690
    |
    Published online on: July 11, 2013
       https://doi.org/10.3892/br.2013.132
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Abstract

Interleukin (IL)‑13 is an immunoregulatory cytokine secreted by numerous immune cells. Its functions are similar to those of IL‑4 and they share a common receptor. This cytokine has been included in recent studies on human tumors and malignant diseases, evoking a scientific interest to investigate the role of IL‑13 and its receptors as novel biomarkers and targets for therapy. Colorectal cancer is one of the most common human malignancies, its prognosis is not promising and the efficacy of molecular‑targeted therapy has not been established. This review summarizes the currently available data on the role of IL‑13 and its receptors in colorectal cancer, including the signaling pathways involved in mediating the effects of IL‑13, the role of IL‑13 and/or its receptors in the prediction of cancer and several drugs targeting IL‑13 or its receptors that are currently under evaluation.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou R, Qian S, Gu X, Chen Z and Xiang J: Interleukin‑13 and its receptors in colorectal cancer (Review). Biomed Rep 1: 687-690, 2013.
APA
Zhou, R., Qian, S., Gu, X., Chen, Z., & Xiang, J. (2013). Interleukin‑13 and its receptors in colorectal cancer (Review). Biomedical Reports, 1, 687-690. https://doi.org/10.3892/br.2013.132
MLA
Zhou, R., Qian, S., Gu, X., Chen, Z., Xiang, J."Interleukin‑13 and its receptors in colorectal cancer (Review)". Biomedical Reports 1.5 (2013): 687-690.
Chicago
Zhou, R., Qian, S., Gu, X., Chen, Z., Xiang, J."Interleukin‑13 and its receptors in colorectal cancer (Review)". Biomedical Reports 1, no. 5 (2013): 687-690. https://doi.org/10.3892/br.2013.132
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou R, Qian S, Gu X, Chen Z and Xiang J: Interleukin‑13 and its receptors in colorectal cancer (Review). Biomed Rep 1: 687-690, 2013.
APA
Zhou, R., Qian, S., Gu, X., Chen, Z., & Xiang, J. (2013). Interleukin‑13 and its receptors in colorectal cancer (Review). Biomedical Reports, 1, 687-690. https://doi.org/10.3892/br.2013.132
MLA
Zhou, R., Qian, S., Gu, X., Chen, Z., Xiang, J."Interleukin‑13 and its receptors in colorectal cancer (Review)". Biomedical Reports 1.5 (2013): 687-690.
Chicago
Zhou, R., Qian, S., Gu, X., Chen, Z., Xiang, J."Interleukin‑13 and its receptors in colorectal cancer (Review)". Biomedical Reports 1, no. 5 (2013): 687-690. https://doi.org/10.3892/br.2013.132
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