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Article

Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta‑analysis

  • Authors:
    • Mengmeng Zhao
    • Xuelian Li
    • Chengzhong Xing
    • Baosen Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Anorectal Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 781-791
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    Published online on: July 15, 2013
       https://doi.org/10.3892/br.2013.134
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Abstract

Colorectal cancer (CRC) is one of the most common types of cancer worldwide and a leading cause of cancer‑related mortality. This meta‑analysis was conducted to determine the effect of methylenetetrahydrofolate reductase (MTHFR) mutants on the risk of CRC. A literature search was conducted on PubMed, Medline and the China National Knowledge Infrastructure (CNKI) databases. Eligible studies were collected based on rigorous criteria of inclusion. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by the fixed‑ or random‑effects model. After all the studies were pooled, the OR of CRC for individuals carrying the MTHFR 677TT genotype, compared to the CC genotype, was 0.89 (95% CI: 0.82‑0.97). When analyzed by ethnicity, Asians with the MTHFR 1298CC genotype exhibited a decreased risk of CRC (OR=0.69; 95% CI: 0.54‑0.89). In a mixed population, a significantly reduced risk of CRC was observed among carriers of the 677TT (OR=0.86; 95% CI: 0.76‑0.96) and the 1298CC (OR=0.82; 95% CI: 0.69‑0.98) genotypes, compared to the wild‑type homozygous genotype. In the subgroup of colon cancer, the OR of 677TT vs. CC+CT was 0.83 (95% CI: 0.72‑0.96) and the OR of 1298CC vs. AA+AC was 0.81 (95% CI: 0.69‑0.96). In the rectal cancer subgroup, the OR of 677TT vs. CC+CT was 0.86 (95% CI: 0.77‑0.97). Therefore, this meta‑analysis suggested that the MTHFR 677T and 1298C alleles were associated with a low risk of CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao M, Li X, Xing C and Zhou B: Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta‑analysis. Biomed Rep 1: 781-791, 2013.
APA
Zhao, M., Li, X., Xing, C., & Zhou, B. (2013). Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta‑analysis. Biomedical Reports, 1, 781-791. https://doi.org/10.3892/br.2013.134
MLA
Zhao, M., Li, X., Xing, C., Zhou, B."Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta‑analysis". Biomedical Reports 1.5 (2013): 781-791.
Chicago
Zhao, M., Li, X., Xing, C., Zhou, B."Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta‑analysis". Biomedical Reports 1, no. 5 (2013): 781-791. https://doi.org/10.3892/br.2013.134
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao M, Li X, Xing C and Zhou B: Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta‑analysis. Biomed Rep 1: 781-791, 2013.
APA
Zhao, M., Li, X., Xing, C., & Zhou, B. (2013). Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta‑analysis. Biomedical Reports, 1, 781-791. https://doi.org/10.3892/br.2013.134
MLA
Zhao, M., Li, X., Xing, C., Zhou, B."Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta‑analysis". Biomedical Reports 1.5 (2013): 781-791.
Chicago
Zhao, M., Li, X., Xing, C., Zhou, B."Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta‑analysis". Biomedical Reports 1, no. 5 (2013): 781-791. https://doi.org/10.3892/br.2013.134
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