Clinical value of circulating liver cancer cells for the diagnosis of hepatocellular carcinoma: A meta-analysis

Jin,Tao; Peng,Hao; Wu,Hongyan

doi:10.3892/br.2013.139

September-October 2013 Volume 1 Issue 5

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September-October 2013 Volume 1 Issue 5

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Article

Clinical value of circulating liver cancer cells for the diagnosis of hepatocellular carcinoma: A meta-analysis

Authors:
- Tao Jin
- Hao Peng
- Hongyan Wu
View Affiliations / Copyright

Affiliations: Department of Orthopedics, Renmin Hospital of Three Gorges University, Yichang, Hubei 443000, P.R. China, Department of Immunology, Medical College of Three Gorges University, Yichang, Hubei 443002, P.R. China
Pages: 731-736
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Published online on: July 18, 2013

https://doi.org/10.3892/br.2013.139
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Abstract

This meta‑analysis was conducted to evaluate the clinical value of circulating tumor cells (CTCs) for liver tumor size, clinical stage and metastasis. the clinical studies on CTCs and liver cancer were electronically and manually retrieved and Review Manager 5.1 software was used to evaluate the quality of the obtained studies, extract data and conduct a meta‑analysis. a total of 5 studies including 535 liver cancer patients were identified. The results of the meta‑analysis revealed that the odds ratio (OR) values of CTCs‑positive rates between large and small tumor size, tumor stage Ⅰ/Ⅱ and Ⅲ/Ⅳ, as well as metastatic and non‑metastatic groups were 12.12 (95% CI: 7.84‑18.74), 0.10 (95% CI: 0.07‑0.16) and 0.09 (95% CI: 0.05‑0.15), respectively, which demonstrated a significant difference. In conclusion, the detection of CTCs in the peripheral blood was clearly associated with tumor size, clinical stage and metastasis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical value of circulating liver cancer cells for the diagnosis of hepatocellular carcinoma: A meta-analysis

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