Antiproliferative effect of the Ginkgo biloba extract is associated with the enhancement of cytochrome P450 1B1 expression in estrogen receptor‑negative breast cancer cells

  • Authors:
    • Xiao‑Dan Zhao
    • Ni Dong
    • Hong‑Tao Man
    • Zhong‑Lin Fu
    • Mei‑Hong Zhang
    • Shuang Kou
    • Shi‑Liang Ma
  • View Affiliations

  • Published online on: July 22, 2013     https://doi.org/10.3892/br.2013.150
  • Pages: 797-801
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Abstract

Ginkgo biloba is a dioecious tree and its extract is a complex mixture that has been used for thousands of years to treat a variety of ailments in traditional Chinese medicine. The aim of this study was to present our observations on the inhibitory effects of different Ginkgo biloba extracts on human breast cancer cell proliferation and growth. Our results demonstrated that treatment of MCF‑7 and MDA‑MB‑231 human breast cancer cells with Ginkgo biloba leaves and ginkgo fruit extract inhibited cell proliferation. it was also observed that this inhibition was accompanied by the enhancement of cytochrome P450 (CYP) 1B1 expression in MDA‑MB‑231 cells. In addition, treatment with ginkgo fruit extract resulted in a higher CYP1B1 expression in MDA‑MB‑231 cells compared to treatment with the Ginkgo biloba leaves extract. Our results suggested that the inhibitory effects of the Ginkgo biloba extract on estrogen receptor‑negative breast cancer proliferation and the induction of CYP1B1 expression may be exerted through an alternative pathway, independent of the estrogen receptor or the aryl hydrocarbon receptor pathway.
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September-October 2013
Volume 1 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Zhao XD, Dong N, Man HT, Fu ZL, Zhang MH, Kou S and Ma SL: Antiproliferative effect of the Ginkgo biloba extract is associated with the enhancement of cytochrome P450 1B1 expression in estrogen receptor‑negative breast cancer cells. Biomed Rep 1: 797-801, 2013
APA
Zhao, X., Dong, N., Man, H., Fu, Z., Zhang, M., Kou, S., & Ma, S. (2013). Antiproliferative effect of the Ginkgo biloba extract is associated with the enhancement of cytochrome P450 1B1 expression in estrogen receptor‑negative breast cancer cells. Biomedical Reports, 1, 797-801. https://doi.org/10.3892/br.2013.150
MLA
Zhao, X., Dong, N., Man, H., Fu, Z., Zhang, M., Kou, S., Ma, S."Antiproliferative effect of the Ginkgo biloba extract is associated with the enhancement of cytochrome P450 1B1 expression in estrogen receptor‑negative breast cancer cells". Biomedical Reports 1.5 (2013): 797-801.
Chicago
Zhao, X., Dong, N., Man, H., Fu, Z., Zhang, M., Kou, S., Ma, S."Antiproliferative effect of the Ginkgo biloba extract is associated with the enhancement of cytochrome P450 1B1 expression in estrogen receptor‑negative breast cancer cells". Biomedical Reports 1, no. 5 (2013): 797-801. https://doi.org/10.3892/br.2013.150