Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
September-October 2013 Volume 1 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-October 2013 Volume 1 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population‑based study

  • Authors:
    • Jing-Jie Zhao
    • Xi-Bing Wang
    • Yun Luan
    • Jun-Li Liu
    • Ling Liu
    • Hong-Ying Jia
  • View Affiliations / Copyright

    Affiliations: Clinical Molecular Biology Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Department of Gynaecology and Obstetrics, Maternal and Child Health Care Service Center of Zaozhuang, Shandong 277102, P.R. China, Central Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Department of Scientific Research, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China
  • Pages: 751-756
    |
    Published online on: July 22, 2013
       https://doi.org/10.3892/br.2013.152
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the association of human leukocyte antigen (HLA) gene polymorphism and clinical phenotypes of patients with mesangial proliferative glomerulonephritis (MsPGN). The genotyping of HLA‑A, HLA‑B and HLA‑DRB1 alleles was detected in 1,536 consecutive MsPGN patients during the previous five years and 2,027 age‑ and gender‑matched healthy individuals by using the polymerase chain reaction‑sequence‑specific primers method. The clinical and pathological data of the patients were collected and the genotype frequencies (GF) and odds ratio (OR) were analyzed. The allele frequencies of HLA‑A*23, A*25, B*15, B*40, B*53 and DRB1*18 were significantly higher in MsPGN patients than in the controls (P<0.05). These alleles were considered as the suspected susceptibility genes (SSG) for MsPGN. Of note, results of the follow‑up survey study demonstrated poorer prognosis of patients with SSG than those without SSG. On the other hand, the frequencies of A*32, A*33, B*50, B*58, B*60, B*71, DRB1*16 were lower in MsPGN patients than in the controls (P<0.05). However, the alleles A*20, A*22, A*35, A*36, A*38, B*21, B*73 and B*78 were not expressed in MsPGN patients. HLA gene polymorphism is associated with hereditary susceptibility to MsPGN. Therefore, there might be corresponding susceptibility and protective genes associated with MsPGN.
View Figures
View References

1 

Zhao J, Jiang Y, Lei Y, Zou K, Wang C, Huang S, Yi F and Xia B: Functional MICA-129 polymorphism and serum levels of soluble MICA are correlated with ulcerative colitis in Chinese patients. J Gastroenterol Hepatol. 26:593–598. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Chang DY, Luo H, Zhou XJ, Chen M and Zhao MH: Association of HLA genes with clinical outcomes of ANCA-associated vasculitis. Clin J Am Soc Nephrol. 7:1293–1299. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Elahi S and Horton H: Association of HLA- alleles with the immune regulation of chronic viral infections. Int J Biochem Cell Biol. 44:1361–1365. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Binh TQ, Phuong PT, Nhung BT, Thoang DD, Lien HT and Thanh DV: Association of the common FTO-rs9939609 polymorphism with type 2 diabetes, independent of obesity-related traits in a Vietnamese population. Gene. 513:31–35. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Mangalam AK, Taneja V and David CS: HLA class II molecules influence susceptibility versus protection in inflammatory diseases by determining the cytokine profile. J Immunol. 190:513–518. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Jonsson T, Gudmundsson KG, Bjarnadottir K, Hjalmarsdotti IB, Gudmundsson S and Arngrimsson R: Association of HLA-DRB1*01 with Dupuytren’s disease. Scand J Rheumatol. 42:45–47. 2013.

7 

Howson JM, Roy MS, Zeitels L, Stevens H and Todd JA: HLA class II gene associations in African American Type 1 diabetes reveal a protective HLA-DRB1*03 haplotype. Diabet Med. 30:710–716. 2013.PubMed/NCBI

8 

Ooi JD, Chang J, O’Sullivan KM, Pedchenko V, Hudson BG, Vandenbark AA, Fugger L, Holdsworth SR and Kitching AR: The HLA-DRB1*15:01-restricted goodpasture’s T cell epitope induces GN. J Am Soc Nephrol. 24:419–431. 2013.

9 

Cui G, Zhang L, Xu Y, Cianflone K, Ding H and Wang DW: Development of a high resolution melting method for genotyping of risk HLA-DQA1 and PLA2R1 alleles and ethnic distribution of these risk alleles. Gene. 514:125–130. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Blankenhorn EP: Comparative immunogenetics of the major histocompatibility complex. Immuno Ser. 43:287–318. 1989.PubMed/NCBI

11 

Sui W, Dai Y, Zhang Y, Chen J, Liu H and Huang H: Proteomic profiling of nephrotic syndrome in serum using magnetic bead based sample fractionation & MALDI-TOF MS. Indian J Med Res. 135:305–311. 2012.PubMed/NCBI

12 

Fekih-Mrissa N, Klai S, Zaouali J, Gritli N and Mrissa R: Association of HLA-DR/DQ polymorphism with myasthenia gravis in Tunisian patients. Clin Neurol Neurosurg. 115:32–36. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Oomura A, Nakamura T, Arakawa M, Ooshima A and Isemura M: Alteration in the extracellular matrix components in human glomerular diseases. Virchows Arch A Pathol Anat Histopathol. 415:151–159. 1989. View Article : Google Scholar : PubMed/NCBI

14 

Liu N, Makino T, Nogaki F, Kusano H, Suyama K, Muso E, Honda G, Kita T and Ono T: Coagulation in the mesangial area promotes ECM accumulation through factor V expression in MsPGN in rats. Am J Physiol Renal Physiol. 287:F612–F620. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Richman IB, Taylor KE, Chung SA, Trupin L, Petri M, Yelin E, Graham RR, Lee A, Behrens TW, Gregersen PK, Seldin MF and Criswell LA: European genetic ancestry is associated with a decreased risk of lupus nephritis. Arthritis Rheum. 64:3374–3382. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Marchini M, Antonioli R, Lleo A, Barili M, Caronni M, Origgi L, Vanoli M and Scorza R: HLA class II antigens associated with lupus nephritis in Italian SLE patients. Hum Immunol. 64:462–468. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Smith HJ, Hanvesakul R, Bentall A, Shabir S, Morgan MD, Briggs D, Cockwell P, Borrows R, Larche M and Ball S: T lymphocyte responses to nonpolymorphic HLA-derived peptides are associated with chronic renal allograft dysfunction. Transplantation. 91:279–286. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Langan LL, Park LP, Hughes TL, Irish A, Luxton G and Witt CS: Christiansen FT: Post-transplant HLA class II antibodies and high soluble CD30 levels are independently associated with poor kidney graft survival. Am J Transplant. 7:847–856. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Shishkin AN, Ashirova KV, Balliuzek MF and Volovnikova VA: The immunogenetic risk factors in the nephrotic syndrome. Ter Arkh. 66:32–34. 1994.(In Russian).

20 

Vaughan RW, Tighe MR, Boki K, Alexoupolos S, Papadakis J, Lanchbury JS, Welsh KI and Williams DG: An analysis of HLA class II gene polymorphism in British and Greek idiopathic membranous nephropathy patients. Eur J Immunogenet. 22:179–186. 1995. View Article : Google Scholar : PubMed/NCBI

21 

Papasteriades C, Hatziyannakos D, Siakotos M, Pappas H, Tarassi K, Nikolopoulou N, Michael S, Kaninis CH, Vosnides G, Sotsiou F and Billis A: HLA antigens in microscopic polyarteritis (MP) with renal involvement. Dis Markers. 13:117–122. 1997.PubMed/NCBI

22 

Fisher M, Pusey CD, Vaughan RW and Rees AJ: Susceptibility to anti-glomerular basement membrane disease is strongly associated with HLA-DRB1 genes. Kidney Int. 51:222–229. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Luo H, Chen M, Cui Z, Yang R, Xu PC, Zhou XJ and Zhao MH: The association of HLA-DQB1, -DQA1 and -DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients. BMC Nephrol. 13:12–21. 2013.PubMed/NCBI

24 

Cheng HF, Nolasco F, Cameron JS, Hildreth G, Neild GH and Hartley B: HLA-DR display by renal tubular epithelium and phenotype of infiltrate in interstitial nephritis. Nephrol Dial Transplant. 4:205–215. 1989.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao J, Wang X, Luan Y, Liu J, Liu L and Jia H: Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population‑based study. Biomed Rep 1: 751-756, 2013.
APA
Zhao, J., Wang, X., Luan, Y., Liu, J., Liu, L., & Jia, H. (2013). Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population‑based study. Biomedical Reports, 1, 751-756. https://doi.org/10.3892/br.2013.152
MLA
Zhao, J., Wang, X., Luan, Y., Liu, J., Liu, L., Jia, H."Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population‑based study". Biomedical Reports 1.5 (2013): 751-756.
Chicago
Zhao, J., Wang, X., Luan, Y., Liu, J., Liu, L., Jia, H."Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population‑based study". Biomedical Reports 1, no. 5 (2013): 751-756. https://doi.org/10.3892/br.2013.152
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao J, Wang X, Luan Y, Liu J, Liu L and Jia H: Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population‑based study. Biomed Rep 1: 751-756, 2013.
APA
Zhao, J., Wang, X., Luan, Y., Liu, J., Liu, L., & Jia, H. (2013). Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population‑based study. Biomedical Reports, 1, 751-756. https://doi.org/10.3892/br.2013.152
MLA
Zhao, J., Wang, X., Luan, Y., Liu, J., Liu, L., Jia, H."Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population‑based study". Biomedical Reports 1.5 (2013): 751-756.
Chicago
Zhao, J., Wang, X., Luan, Y., Liu, J., Liu, L., Jia, H."Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population‑based study". Biomedical Reports 1, no. 5 (2013): 751-756. https://doi.org/10.3892/br.2013.152
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team