Calcium‑permeable AMPA receptors in neonatal hypoxic‑ischemic encephalopathy (Review)

  • Authors:
    • Xiao‑Juan Tang
    • Feng Xing
  • View Affiliations

  • Published online on: July 30, 2013     https://doi.org/10.3892/br.2013.154
  • Pages: 828-832
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Abstract

Hypoxic‑ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn and may result in long‑term devastating consequences. Excessive stimulation of glutamate receptors (GluRs) is a pivotal mechanism underlying ischemia‑induced selective and delayed neuronal death. Although initial studies focused on N‑methyl‑D‑aspartic acid (NMDA) receptors as critical mediators in HIE, subsequent studies supported a more central role for α‑amino‑3‑hydroxy‑5‑methyl‑4‑isoxazolepropionic acid (AMPA) receptors (AMPARs), particularly Ca2+‑permeable AMPARs, in brain damage associated with hypoxia‑ischemia. This study reviewedthe important role of Ca2+‑permeable AMPARs in HIE and the future potential neuroprotective strategies associated with Ca2+‑permeable AMPARs.
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November-December 2013
Volume 1 Issue 6

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Tang XJ and Tang XJ: Calcium‑permeable AMPA receptors in neonatal hypoxic‑ischemic encephalopathy (Review). Biomed Rep 1: 828-832, 2013
APA
Tang, X., & Tang, X. (2013). Calcium‑permeable AMPA receptors in neonatal hypoxic‑ischemic encephalopathy (Review). Biomedical Reports, 1, 828-832. https://doi.org/10.3892/br.2013.154
MLA
Tang, X., Xing, F."Calcium‑permeable AMPA receptors in neonatal hypoxic‑ischemic encephalopathy (Review)". Biomedical Reports 1.6 (2013): 828-832.
Chicago
Tang, X., Xing, F."Calcium‑permeable AMPA receptors in neonatal hypoxic‑ischemic encephalopathy (Review)". Biomedical Reports 1, no. 6 (2013): 828-832. https://doi.org/10.3892/br.2013.154