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November-December 2013 Volume 1 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Network analysis of microRNAs, genes and their regulation in human bladder cancer

  • Authors:
    • Yang Li
    • Zhiwen Xu
    • Kunhao Wang
    • Ning Wang
    • Minghui Zhu
  • View Affiliations / Copyright

    Affiliations: College of Computer Science and Technology, Jilin University, Changchun, Jilin 130012, P.R. China
  • Pages: 918-924
    |
    Published online on: August 19, 2013
       https://doi.org/10.3892/br.2013.157
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Abstract

Bladder cancer (BC) is the fifth most common malignancy occurring worldwide and a significant cause of cancer‑related morbidity and mortality. Although BC is a serious health issue, studies available concerning the relationship of genes, microRNAs (miRNAs) and their host genes has been lacking. In the present study, we assessed experimentally validated data from various sources that reported the effect of miRNA on various diseases, miRNA targeting of mRNAs, and combined these data with initial transcription factor (TF) binding site predictions within miRNA promoter regions. Topology networks obtained in this study included the differentially expressed, BC‑associated and global networks. The three networks may be used to assess the effect of miRNAs and their regulation in human BC. By comparing and analyzing the similarities and differences among the three networks, key nodes with the largest potential of affecting the behavior of a particular network were identified. The results also showed potentially substantially influential miRNAs and TFs, which revealed subnetworks demonstrating the mechanisms involved as well as regulatory miRNA network motifs in human BC. Regulatory pathways regarding differentially expressed elements, such as genes and miRNAs, demonstrate self‑adapting associations including, self‑adapting associations and feedback loops in genes MYC, TP53, PTEN and 10 differentially expressed miRNAs. The differentially expressed network partially identified the BC mechanism. miRNA‑targeted human BC genes were also enriched in highly relevant pathways, cell cycle regulation and apoptosis. The present study systematically delineated the pathogenesis of BC and provided theoretical foundations for gene therapy investigators to focu attention on key genes and miRNAs in future studies.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Xu Z, Wang K, Wang N and Zhu M: Network analysis of microRNAs, genes and their regulation in human bladder cancer. Biomed Rep 1: 918-924, 2013.
APA
Li, Y., Xu, Z., Wang, K., Wang, N., & Zhu, M. (2013). Network analysis of microRNAs, genes and their regulation in human bladder cancer. Biomedical Reports, 1, 918-924. https://doi.org/10.3892/br.2013.157
MLA
Li, Y., Xu, Z., Wang, K., Wang, N., Zhu, M."Network analysis of microRNAs, genes and their regulation in human bladder cancer". Biomedical Reports 1.6 (2013): 918-924.
Chicago
Li, Y., Xu, Z., Wang, K., Wang, N., Zhu, M."Network analysis of microRNAs, genes and their regulation in human bladder cancer". Biomedical Reports 1, no. 6 (2013): 918-924. https://doi.org/10.3892/br.2013.157
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Xu Z, Wang K, Wang N and Zhu M: Network analysis of microRNAs, genes and their regulation in human bladder cancer. Biomed Rep 1: 918-924, 2013.
APA
Li, Y., Xu, Z., Wang, K., Wang, N., & Zhu, M. (2013). Network analysis of microRNAs, genes and their regulation in human bladder cancer. Biomedical Reports, 1, 918-924. https://doi.org/10.3892/br.2013.157
MLA
Li, Y., Xu, Z., Wang, K., Wang, N., Zhu, M."Network analysis of microRNAs, genes and their regulation in human bladder cancer". Biomedical Reports 1.6 (2013): 918-924.
Chicago
Li, Y., Xu, Z., Wang, K., Wang, N., Zhu, M."Network analysis of microRNAs, genes and their regulation in human bladder cancer". Biomedical Reports 1, no. 6 (2013): 918-924. https://doi.org/10.3892/br.2013.157
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