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Review

Research and clinical applications of molecular biomarkers in gastrointestinal carcinoma (Review)

  • Authors:
    • Feng Jiao
    • Ziliang Jin
    • Lei Wang
    • Liwei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 201620, P.R. China
  • Pages: 819-827
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    Published online on: August 20, 2013
       https://doi.org/10.3892/br.2013.158
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Abstract

Gastrointestinal (GI) carcinoma is a common malignant disease worldwide. Its development and progression is a multistage process involving a multifactorial etiology. Although the detailed mechanisms of the development of GI carcinoma remain controversial, the elucidation of its molecular biology over the last few years has resulted in a better perspective on its epidemiology, carcinogenesis and pathogenesis. More significantly, it is currently possible to use biological indicators or biomarkers in differential diagnosis, prognostic evaluation and specific clinical interventions. In this review, we aimed to describe the biomarkers of pathogenesis, invasion, metastasis and prognosis of GI carcinoma and discuss their potential clinical applications. The majority of these biomarkers, such as tumor‑associated antigens, oncogenes and tumor suppressor genes, metastasis‑associated genes, cell adhesion molecules, cytokines, growth factors and microRNAs, are currently broadly applicable.
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Copy and paste a formatted citation
Spandidos Publications style
Jiao F, Jin Z, Wang L and Wang L: Research and clinical applications of molecular biomarkers in gastrointestinal carcinoma (Review). Biomed Rep 1: 819-827, 2013.
APA
Jiao, F., Jin, Z., Wang, L., & Wang, L. (2013). Research and clinical applications of molecular biomarkers in gastrointestinal carcinoma (Review). Biomedical Reports, 1, 819-827. https://doi.org/10.3892/br.2013.158
MLA
Jiao, F., Jin, Z., Wang, L., Wang, L."Research and clinical applications of molecular biomarkers in gastrointestinal carcinoma (Review)". Biomedical Reports 1.6 (2013): 819-827.
Chicago
Jiao, F., Jin, Z., Wang, L., Wang, L."Research and clinical applications of molecular biomarkers in gastrointestinal carcinoma (Review)". Biomedical Reports 1, no. 6 (2013): 819-827. https://doi.org/10.3892/br.2013.158
Copy and paste a formatted citation
x
Spandidos Publications style
Jiao F, Jin Z, Wang L and Wang L: Research and clinical applications of molecular biomarkers in gastrointestinal carcinoma (Review). Biomed Rep 1: 819-827, 2013.
APA
Jiao, F., Jin, Z., Wang, L., & Wang, L. (2013). Research and clinical applications of molecular biomarkers in gastrointestinal carcinoma (Review). Biomedical Reports, 1, 819-827. https://doi.org/10.3892/br.2013.158
MLA
Jiao, F., Jin, Z., Wang, L., Wang, L."Research and clinical applications of molecular biomarkers in gastrointestinal carcinoma (Review)". Biomedical Reports 1.6 (2013): 819-827.
Chicago
Jiao, F., Jin, Z., Wang, L., Wang, L."Research and clinical applications of molecular biomarkers in gastrointestinal carcinoma (Review)". Biomedical Reports 1, no. 6 (2013): 819-827. https://doi.org/10.3892/br.2013.158
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