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Article

FAS‑670 gene polymorphism and cervical carcinogenesis risk: A meta‑analysis

  • Authors:
    • Qiaoying Huang
    • Jie Wang
    • Yanling Hu
  • View Affiliations / Copyright

    Affiliations: Graduate School, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China, Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China
  • Pages: 889-894
    |
    Published online on: August 20, 2013
       https://doi.org/10.3892/br.2013.159
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Abstract

FAS is a cell surface receptor that plays an important role in the etiology of cancer. Previous studies on the association between FAS‑670 polymorphism and cervical carcinogenesis failed to reach a consensus; therefore, this meta‑analysis was conducted to estimate the association of FAS‑670 polymorphism and the risk of cervical cancer. This meta‑analysis included 10 studies on FAS‑670 genotyping, including a total of 2,901 cases and 2,831 controls. The complete overdominant model was applied in our meta‑analysis [AB vs. AA: odds ratio (OR)=0.879, 95% confidence interval (CI): 0.775‑0.998, P=0.046; BB vs. AA: OR=0.903, 95% CI: 0.775‑1.052, P=0.190]. The random effects OR was 1.13 (95% CI: 0.95‑1.34, I2=52.7%, Pheterogeneity=0.03). An ethnic subgroup analysis was subsequently performed. The OR for Asians was 1.25 (6 comparisons, 95% CI: 1.05‑1.48, I2=23.5%, Pheterogeneity=0.03), whereas for Caucasians, no significant association was observed between FAS‑670 polymorphism and cervical carcinogenesis (4 comparisons, OR=0.96, 95% CI: 0.75‑1.24, I2=45.9%, Pheterogeneity=0.14).
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Copy and paste a formatted citation
Spandidos Publications style
Huang Q, Wang J and Hu Y: FAS‑670 gene polymorphism and cervical carcinogenesis risk: A meta‑analysis. Biomed Rep 1: 889-894, 2013.
APA
Huang, Q., Wang, J., & Hu, Y. (2013). FAS‑670 gene polymorphism and cervical carcinogenesis risk: A meta‑analysis. Biomedical Reports, 1, 889-894. https://doi.org/10.3892/br.2013.159
MLA
Huang, Q., Wang, J., Hu, Y."FAS‑670 gene polymorphism and cervical carcinogenesis risk: A meta‑analysis". Biomedical Reports 1.6 (2013): 889-894.
Chicago
Huang, Q., Wang, J., Hu, Y."FAS‑670 gene polymorphism and cervical carcinogenesis risk: A meta‑analysis". Biomedical Reports 1, no. 6 (2013): 889-894. https://doi.org/10.3892/br.2013.159
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Q, Wang J and Hu Y: FAS‑670 gene polymorphism and cervical carcinogenesis risk: A meta‑analysis. Biomed Rep 1: 889-894, 2013.
APA
Huang, Q., Wang, J., & Hu, Y. (2013). FAS‑670 gene polymorphism and cervical carcinogenesis risk: A meta‑analysis. Biomedical Reports, 1, 889-894. https://doi.org/10.3892/br.2013.159
MLA
Huang, Q., Wang, J., Hu, Y."FAS‑670 gene polymorphism and cervical carcinogenesis risk: A meta‑analysis". Biomedical Reports 1.6 (2013): 889-894.
Chicago
Huang, Q., Wang, J., Hu, Y."FAS‑670 gene polymorphism and cervical carcinogenesis risk: A meta‑analysis". Biomedical Reports 1, no. 6 (2013): 889-894. https://doi.org/10.3892/br.2013.159
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