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Article

Inhibition of ubiquitin protein expression and 20S proteasome activity by irbesartan prevents post‑infarction ventricular remodeling and decreases TNF‑α generation

  • Authors:
    • Naiju Zhang
    • Tianping Chen
    • Chunfang Liu
    • Bi Tang
    • Ling Nie
    • Huiling An
    • Duilan Zhao
    • Li Pan
    • Meiling Yu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China, Department of Cardiovasology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China, Department of Pharmacy, Bengbu Second People's Hospital, Bengbu, Anhui 233000, P.R. China
  • Pages: 935-939
    |
    Published online on: September 12, 2013
       https://doi.org/10.3892/br.2013.165
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Abstract

Myocardial infarction (MI) may induce severe alterations of the cardiac contractile function that may, in turn, lead to heart failure (HF). The ubiquitin‑proteasome system (UPS) plays a critical role in cardiac remodeling following MI. Angiotensin II type 1 receptor (AT1R) blockers effectively prevent left ventricular (LV) remodeling. However, it has not been elucidated whether the preventive effect of AT1R‑blockers on LV remodeling is mediated through the UPS pathway. In the present study, with the use of cardiac morphometric parameters, haemodynamic measurements and enzyme‑linked immunosorbent assay, we demonstrated that post‑ischemic HF rats exhibited a significant increase in ventricular remodeling and irbesartan was effective in reversing cardiac remodeling. The expression of TNF‑α, ubiquitin protein and 20S proteasome were significantly increased in the MI control group and irbesartan was shown to dose‑dependently inhibit the expression of TNF‑α, ubiquitin protein and 20S proteasome. In conclusion, it was hypothesized that UPS signaling is involved in ventricular remodeling following MI and the mechanism underlying the effect of irbesartan on ventricular remodeling may be associated with the downregulation of the expression of TNF‑α, ubiquitin protein and 20S proteasome.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang N, Chen T, Liu C, Tang B, Nie L, An H, Zhao D, Pan L and Yu M: Inhibition of ubiquitin protein expression and 20S proteasome activity by irbesartan prevents post‑infarction ventricular remodeling and decreases TNF‑α generation. Biomed Rep 1: 935-939, 2013.
APA
Zhang, N., Chen, T., Liu, C., Tang, B., Nie, L., An, H. ... Yu, M. (2013). Inhibition of ubiquitin protein expression and 20S proteasome activity by irbesartan prevents post‑infarction ventricular remodeling and decreases TNF‑α generation. Biomedical Reports, 1, 935-939. https://doi.org/10.3892/br.2013.165
MLA
Zhang, N., Chen, T., Liu, C., Tang, B., Nie, L., An, H., Zhao, D., Pan, L., Yu, M."Inhibition of ubiquitin protein expression and 20S proteasome activity by irbesartan prevents post‑infarction ventricular remodeling and decreases TNF‑α generation". Biomedical Reports 1.6 (2013): 935-939.
Chicago
Zhang, N., Chen, T., Liu, C., Tang, B., Nie, L., An, H., Zhao, D., Pan, L., Yu, M."Inhibition of ubiquitin protein expression and 20S proteasome activity by irbesartan prevents post‑infarction ventricular remodeling and decreases TNF‑α generation". Biomedical Reports 1, no. 6 (2013): 935-939. https://doi.org/10.3892/br.2013.165
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang N, Chen T, Liu C, Tang B, Nie L, An H, Zhao D, Pan L and Yu M: Inhibition of ubiquitin protein expression and 20S proteasome activity by irbesartan prevents post‑infarction ventricular remodeling and decreases TNF‑α generation. Biomed Rep 1: 935-939, 2013.
APA
Zhang, N., Chen, T., Liu, C., Tang, B., Nie, L., An, H. ... Yu, M. (2013). Inhibition of ubiquitin protein expression and 20S proteasome activity by irbesartan prevents post‑infarction ventricular remodeling and decreases TNF‑α generation. Biomedical Reports, 1, 935-939. https://doi.org/10.3892/br.2013.165
MLA
Zhang, N., Chen, T., Liu, C., Tang, B., Nie, L., An, H., Zhao, D., Pan, L., Yu, M."Inhibition of ubiquitin protein expression and 20S proteasome activity by irbesartan prevents post‑infarction ventricular remodeling and decreases TNF‑α generation". Biomedical Reports 1.6 (2013): 935-939.
Chicago
Zhang, N., Chen, T., Liu, C., Tang, B., Nie, L., An, H., Zhao, D., Pan, L., Yu, M."Inhibition of ubiquitin protein expression and 20S proteasome activity by irbesartan prevents post‑infarction ventricular remodeling and decreases TNF‑α generation". Biomedical Reports 1, no. 6 (2013): 935-939. https://doi.org/10.3892/br.2013.165
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