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Article

Association of genetic polymorphism of HLA‑DRB1 antigens with the susceptibility to lepromatous leprosy

  • Authors:
    • Monica Escamilla‑Tilch
    • Nora Magdalena Torres‑Carrillo
    • Rosalio Ramos Payan
    • Maribel Aguilar‑Medina
    • Ma Isabel Salazar
    • Mary Fafutis‑Morris
    • Roberto Arenas‑Guzman
    • Sergio Estrada‑Parra
    • Iris Estrada‑Garcia
    • Julio Granados
  • View Affiliations / Copyright

    Affiliations: Department of Immunology, National School of Biological Sciences, National Polytechnic Institute, Mexico City 11340, Mexico, Department of Basic Science Research, National Institute of Geriatrics, Ministry of Health, Mexico City, 10200, Mexico, School of Chemical and Biological Sciences, Autonomous University of Sinaloa, Culiacan, Sinaloa 80040, Mexico, Department of Immunology, National School of Biological Sciences, National Polytechnic Institute, Mexico City 11340, Mexico, Center for Research in Immunology and Dermatology, Dermatological Institute of Jalisco, Guadalajara, Jalisco 45190, Mexico, Mycology Section, General Hospital Dr Manuel Gea Gonzalez, Mexico City 14000, Mexico, Department of Transplantation, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City 14000, Mexico
  • Pages: 945-949
    |
    Published online on: September 19, 2013
       https://doi.org/10.3892/br.2013.167
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Abstract

Despite the introduction of multidrug therapy and the overall reduction of leprosy prevalence in Mexico, the disease remains endemic in certain regions of the country. A genetic basis for the immune susceptibility to Mycobacterium leprae has already been established in different populations worldwide. In this study, we investigated the possible association of the HLA‑DRB1 alleles with leprosy in a Mexican mestizo population. The results demonstrated that the HLA‑DRB1*01 allele is associated with lepromatous and dimorphic leprosy [P<0.001, odds ratio (OR)=4.6, 95% confidence interval (95% CI): 1.8‑11.4; and P=0.03, OR=6.2, 95% CI: 1.1‑31.6, respectively] and the frequency of the HLA‑DRB1*08 allele was found to be significantly lower among leprosy patients compared to controls (P=0.046, OR=2.4, 95% CI: 1‑5.8). In conclusion, although the association of the HLA‑DR locus with leprosy has been established in different populations and several studies have demonstrated significant differences in the DR alleles, this study demonstrated an association of the HLA‑DRB1*01 allele with susceptibility to lepromatous and dimorphic leprosy, as well as an association of the HLA‑DRB1*08 allele with protection against leprosy in a Mexican mestizo population.
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Copy and paste a formatted citation
Spandidos Publications style
Escamilla‑Tilch M, Torres‑Carrillo NM, Ramos Payan R, Aguilar‑Medina M, Salazar MI, Fafutis‑Morris M, Arenas‑Guzman R, Estrada‑Parra S, Estrada‑Garcia I, Granados J, Granados J, et al: Association of genetic polymorphism of HLA‑DRB1 antigens with the susceptibility to lepromatous leprosy. Biomed Rep 1: 945-949, 2013.
APA
Escamilla‑Tilch, M., Torres‑Carrillo, N.M., Ramos Payan, R., Aguilar‑Medina, M., Salazar, M.I., Fafutis‑Morris, M. ... Granados, J. (2013). Association of genetic polymorphism of HLA‑DRB1 antigens with the susceptibility to lepromatous leprosy. Biomedical Reports, 1, 945-949. https://doi.org/10.3892/br.2013.167
MLA
Escamilla‑Tilch, M., Torres‑Carrillo, N. M., Ramos Payan, R., Aguilar‑Medina, M., Salazar, M. I., Fafutis‑Morris, M., Arenas‑Guzman, R., Estrada‑Parra, S., Estrada‑Garcia, I., Granados, J."Association of genetic polymorphism of HLA‑DRB1 antigens with the susceptibility to lepromatous leprosy". Biomedical Reports 1.6 (2013): 945-949.
Chicago
Escamilla‑Tilch, M., Torres‑Carrillo, N. M., Ramos Payan, R., Aguilar‑Medina, M., Salazar, M. I., Fafutis‑Morris, M., Arenas‑Guzman, R., Estrada‑Parra, S., Estrada‑Garcia, I., Granados, J."Association of genetic polymorphism of HLA‑DRB1 antigens with the susceptibility to lepromatous leprosy". Biomedical Reports 1, no. 6 (2013): 945-949. https://doi.org/10.3892/br.2013.167
Copy and paste a formatted citation
x
Spandidos Publications style
Escamilla‑Tilch M, Torres‑Carrillo NM, Ramos Payan R, Aguilar‑Medina M, Salazar MI, Fafutis‑Morris M, Arenas‑Guzman R, Estrada‑Parra S, Estrada‑Garcia I, Granados J, Granados J, et al: Association of genetic polymorphism of HLA‑DRB1 antigens with the susceptibility to lepromatous leprosy. Biomed Rep 1: 945-949, 2013.
APA
Escamilla‑Tilch, M., Torres‑Carrillo, N.M., Ramos Payan, R., Aguilar‑Medina, M., Salazar, M.I., Fafutis‑Morris, M. ... Granados, J. (2013). Association of genetic polymorphism of HLA‑DRB1 antigens with the susceptibility to lepromatous leprosy. Biomedical Reports, 1, 945-949. https://doi.org/10.3892/br.2013.167
MLA
Escamilla‑Tilch, M., Torres‑Carrillo, N. M., Ramos Payan, R., Aguilar‑Medina, M., Salazar, M. I., Fafutis‑Morris, M., Arenas‑Guzman, R., Estrada‑Parra, S., Estrada‑Garcia, I., Granados, J."Association of genetic polymorphism of HLA‑DRB1 antigens with the susceptibility to lepromatous leprosy". Biomedical Reports 1.6 (2013): 945-949.
Chicago
Escamilla‑Tilch, M., Torres‑Carrillo, N. M., Ramos Payan, R., Aguilar‑Medina, M., Salazar, M. I., Fafutis‑Morris, M., Arenas‑Guzman, R., Estrada‑Parra, S., Estrada‑Garcia, I., Granados, J."Association of genetic polymorphism of HLA‑DRB1 antigens with the susceptibility to lepromatous leprosy". Biomedical Reports 1, no. 6 (2013): 945-949. https://doi.org/10.3892/br.2013.167
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