Association of genetic variants of CELSR1 and 3q28 with hypertension in community‑dwelling individuals

Ueyama,Chikara; Horibe,Hideki; Fujimaki,Tetsuo; Oguri,Mitsutoshi; Kato,Kimihiko; Yamada,Yoshiji

doi:10.3892/br.2013.168

November-December 2013 Volume 1 Issue 6

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November-December 2013 Volume 1 Issue 6

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Article

Association of genetic variants of CELSR1 and 3q28 with hypertension in community‑dwelling individuals

Authors:
- Chikara Ueyama
- Hideki Horibe
- Tetsuo Fujimaki
- Mitsutoshi Oguri
- Kimihiko Kato
- Yoshiji Yamada
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Affiliations: Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi 507-8522, Japan, Department of Cardiovascular Medicine, Inabe General Hospital, Inabe 511-0428, Japan, Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya 453-0046, Japan, Department of Internal Medicine, Meitoh Hospital, Nagoya 465-0025, Japan, Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu 514-8507, Japan
Pages: 840-844
|
Published online on: September 24, 2013

https://doi.org/10.3892/br.2013.168
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Abstract

Findings of previous studies demonstrated that rs6007897 (C→T, Ala2268Thr) of the cadherin, epidermal growth factor (EGF) laminin A G‑type repeats (LAG) seven‑pass G‑type receptor 1 gene (CELSR1) and rs9846911 (A→G) at chromosome 3q28 were significantly associated with ischemic stroke and chronic kidney disease, respectively. Given that hypertension is a risk factor for both ischemic stroke and chronic kidney disease, it was hypothesized that the association of rs6007897 with ischemic stroke or of rs9846911 with chronic kidney disease might be attributable, at least in part, to their effects on genetic susceptibility to hypertension. The purpose of the present study was to examine a possible association of rs6007897 of CELSR1 or rs9846911 at 3q28 with hypertension in community‑dwelling individuals. Study subjects comprised 5,959 community‑dwelling individuals (1,670 subjects with hypertension and 4,289 controls) who were recruited to a population‑based cohort study. Comparisons of allele frequencies by the Chi‑square test revealed that rs6007897 of CELSR1 (P=0.0280) and rs9846911 at 3q28 (P=0.0171) were significantly associated with the prevalence of hypertension. Multivariate logistic regression analysis with adjustment for age, gender, body mass index (BMI), smoking status, the serum concentration of creatinine and the prevalence of dyslipidemia and diabetes mellitus revealed that rs6007897 (P=0.0308; recessive model; odds ratio, 1.56) and rs9846911 (P=0.0353; dominant model; odds ratio, 1.22) were significantly associated with hypertension with the T allele rs6007897 and the G allele rs984691 representing risk factors for this condition. CELSR1 and 3q28 may thus be susceptibility loci for hypertension.

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1	Lifton RP, Gharavi AG and Geller DS: Molecular mechanisms of human hypertension. Cell. 104:545–556. 2001. View Article : Google Scholar
2	Dominiczak AF, Negrin DC, Clark JS, Brosnan MJ, McBride MW and Alexander MY: Genes and hypertension from gene mapping in experimental models to vascular gene transfer strategies. Hypertension. 35:164–172. 2000. View Article : Google Scholar : PubMed/NCBI
3	Kannel WB: Elevated systolic blood pressure as a cardiovascular risk factor. Am J Cardiol. 85:251–255. 2000. View Article : Google Scholar : PubMed/NCBI
4	Kannel WB: Historic perspectives on the relative contributions of diastolic and systolic blood pressure elevation to cardiovascular risk profile. Am Heart J. 138:S205–S210. 1999. View Article : Google Scholar : PubMed/NCBI
5	The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 447:661–678. 2007. View Article : Google Scholar : PubMed/NCBI
6	Newton-Cheh C, Johnson T, Gateva V, et al: Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet. 41:666–676. 2009. View Article : Google Scholar : PubMed/NCBI
7	Levy D, Ehret GB, Rice K, et al: Genome-wide association study of blood pressure and hypertension. Nat Genet. 41:677–687. 2009. View Article : Google Scholar : PubMed/NCBI
8	Org E, Eyheramendy S, Juhanson P, et al: Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. Hum Mol Genet. 18:2288–2296. 2009. View Article : Google Scholar : PubMed/NCBI
9	Adeyemo A, Gerry N, Chen G, et al: A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet. 5:e10005642009. View Article : Google Scholar : PubMed/NCBI
10	Kato N, Miyata T, Tabara Y, et al: High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project. Hum Mol Genet. 17:617–627. 2008. View Article : Google Scholar : PubMed/NCBI
11	Yamada Y, Fuku N, Tanaka M, et al: Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. Atherosclerosis. 207:144–149. 2009. View Article : Google Scholar : PubMed/NCBI
12	Yamada Y, Nishida T, Ichihara S, et al: Identification of chromosome 3q28 and ALPK1 as susceptibility loci for chronic kidney disease in Japanese individuals by a genome-wide association study. J Med Genet. 50:410–418. 2013. View Article : Google Scholar : PubMed/NCBI
13	Perloff D, Grim C, Flack J, Frohlich ED, Hill M, McDonald M and Morgenstern BZ: Human blood pressure determination by sphygmomanometry. Circulation. 88:2460–2470. 1993. View Article : Google Scholar : PubMed/NCBI
14	Itoh Y, Mizuki N, Shimada T, et al: High-throughput DNA typing of HLA-A, -B, -C, and -DRB1 loci by a PCR-SSOP-Luminex method in the Japanese population. Immunogenetics. 57:717–729. 2005. View Article : Google Scholar : PubMed/NCBI
15	Hadjantonakis AK, Sheward WJ, Harmar AJ, et al: Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter. Genomics. 45:97–104. 1997. View Article : Google Scholar : PubMed/NCBI
16	Wu Q and Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 97:779–790. 1999. View Article : Google Scholar : PubMed/NCBI
17	Nollet F, Kools P and van Roy F: Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. J Mol Biol. 299:551–572. 2000. View Article : Google Scholar
18	Gouveia LO, Sobral J, Vicente AM, Ferro JM and Oliveira SA: Replication of the CELSR1 association with ischemic stroke in a Portuguese case-control cohort. Atherosclerosis. 217:260–262. 2011. View Article : Google Scholar : PubMed/NCBI
19	Katoh Y and Katoh M: Comparative integromics on FAT1, FAT2, FAT3 and FAT4. Int J Mol Med. 18:523–528. 2006.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Association of genetic variants of CELSR1 and 3q28 with hypertension in community‑dwelling individuals

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