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Review

Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review)

  • Authors:
    • Xianglin Dong
    • Shaolin Mao
    • Hao Wen
  • View Affiliations / Copyright

    Affiliations: Department of Burns and Plastic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China, Department of Hydatid Hepatobiliary, Digestive and Vascular Surgery Centre, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China
  • Pages: 833-836
    |
    Published online on: September 25, 2013
       https://doi.org/10.3892/br.2013.169
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Abstract

It was previously demonstrated that the main cause behind keloid formation may be keloid fibroblast abnormalities, which are closely associated with the microenvironment of the keloid lesion. The post‑traumatic and chronic inflammation of the keloid lesion area suggest that inflammatory mediators play an important role in the keloid microenvironment and are crucial for keloid fibroblast abnormalities. In this study, we hypothesized that the mechanism underlying keloid formation may involve the continuous upregulation of proinflammatory gene expression in keloid lesions. This hypothesis may explain the inflammatory response, invasive growth and recurrence following resection of keloids, as well as the selective localization of keloids in specific parts of a patient's body and the differences in localization among different patients.
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1 

Al-Attar A, Mess S, Thomassen JM, Kauffman CL and Davison SP: Keloid pathogenesis and treatment. Plast Reconstr Surg. 117:286–300. 2006. View Article : Google Scholar

2 

Atiyeh BS, Costagliola M and Hayek SN: Keloid or hypertrophic scar: the controversy: review of the literature. Ann Plast Surg. 54:676–680. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Estrem SA, Domayer M, Bardach J and Cram AE: Implantation of human keloid into athymic mice. Laryngoscope. 97:1214–1218. 1987. View Article : Google Scholar : PubMed/NCBI

4 

Pierce HE: Keloids: enigma of the plastic surgeon. J Natl Med Assoc. 71:1177–1180. 1979.PubMed/NCBI

5 

Huang C, Akaishi S, Hyakusoku H and Ogawa R: Are keloid and hypertrophic scar different forms of the same disorder? A fibroproliferative skin disorder hypothesis based on keloid findings. Int Wound J. Nov 22–2012.(Epub ahead of print).

6 

de Mesquita CJ: About strawberry, crab claws, and the Sir James Black’s invention. Hypothesis: can we battle keloids with propranolol? Med Hypotheses. 74:353–359. 2010.PubMed/NCBI

7 

Akaishi S, Ogawa R and Hyakusoku H: Keloid and hypertrophic scar: neurogenic inflammation hypotheses. Med Hypotheses. 71:32–38. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Alonso PE, Rioja LF and Pera C: Keloids: A viral hypothesis. Med Hypotheses. 70:156–166. 2008. View Article : Google Scholar : PubMed/NCBI

9 

O’Brien L and Jones DJ: Silicone gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database Syst Rev. 9:Sep 12–2013.(Epub ahead of print).

10 

Kischer CW, Shetlar MR and Chvapil M: Hypertrophic scars and keloids: a review and new concept concerning their origin. Scan Electron Microsc. 4:1699–1713. 1982.PubMed/NCBI

11 

Tredget EE, Nedelec B, Scott PG and Ghahary A: Hypertrophic scars, keloids, and contractures. The cellular and molecular basis for therapy. Surg Clin North Am. 77:701–730. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Sandulache VC, Parekh A, Li-Korotky H, Dohar JE and Hebda PA: Prostaglandin E2 inhibition of keloid fibroblast migration, contraction, and transforming growth factor (TGF)-beta 1-induced collagen synthesis. Wound Repair Regen. 15:122–133. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Clark RA: Cutaneous tissue repair: basic biologic considerations. I J Am Acad Dermatol. 13:701–725. 1985. View Article : Google Scholar : PubMed/NCBI

14 

Sahl WJ Jr and Clever H: Cutaneous scars: Part I. Int J Dermatol. 33:681–691. 1994. View Article : Google Scholar : PubMed/NCBI

15 

Nakaoka H, Miyauchi S and Miki Y: Proliferating activity of dermal fibroblasts in keloids and hypertrophic scars. Acta Derm Venereol. 75:102–104. 1995.PubMed/NCBI

16 

Nedelec B, Shankowsky H, Scott PG, Ghahary A and Tredget EE: Myofibroblasts and apoptosis in human hypertrophic scars: the effect of interferon-alpha2b. Surgery. 130:798–808. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Marneros AG and Krieg T: Keloids - clinical diagnosis, pathogenesis, and treatment options. J Dtsch Dermatol Ges. 2:905–913. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Ladin DA, Hou Z, Patel D, et al: p53 and apoptosis alterations in keloids and keloid fibroblasts. Wound Repair Regen. 6:28–37. 1998. View Article : Google Scholar : PubMed/NCBI

19 

Messadi DV, Le A, Berg S, et al: Effect of TGF-beta 1 on PDGF receptors expression in human scar fibroblasts. Front Biosci. 3:a16–a22. 1998.PubMed/NCBI

20 

Sayah DN, Soo C, Shaw WW, et al: Downregulation of apoptosis-related genes in keloid tissues. J Surg Res. 87:209–216. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Fujiwara M, Muragaki Y and Ooshima A: Keloid-derived fibroblasts show increased secretion of factors involved in collagen turnover and depend on matrix metalloproteinase for migration. Br J Dermatol. 153:295–300. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Calderon M, Lawrence WT and Banes AJ: Increased proliferation in keloid fibroblasts wounded in vitro. J Surg Res. 61:343–347. 1996. View Article : Google Scholar : PubMed/NCBI

23 

Moon JH, Kwak SS, Park G, et al: Isolation and characterization of multipotent human keloid-derived mesenchymal-like stem cells. Stem Cells Dev. 17:713–724. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Chen W, Fu X, Sun X, et al: Analysis of differentially expressed genes in keloids and normal skin with cDNA microarray. J Surg Res. 113:208–216. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Messadi DV, Doung HS, Zhang Q, et al: Activation of NFkappaB signal pathways in keloid fibroblasts. Arch Dermatol Res. 296:125–133. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Tosa M, Ghazizadeh M, Shimizu H, et al: Global gene expression analysis of keloid fibroblasts in response to electron beam irradiation reveals the involvement of interleukin-6 pathway. J Invest Dermatol. 124:704–713. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Ehrlich HP, Desmouliere A, Diegelmann RF, et al: Morphological and immunochemical differences between keloid and hypertrophic scar. Am J Pathol. 145:105–113. 1994.PubMed/NCBI

28 

Szulgit G, Rudolph R, Wandel A, et al: Alterations in fibroblast alpha1beta1 integrin collagen receptor expression in keloids and hypertrophic scars. J Invest Dermatol. 118:409–415. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Alster TS and Tanzi EL: Hypertrophic scars and keloids: etiology and management. Am J Clin Dermatol. 4:235–243. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Tuan TL and Nichter LS: The molecular basis of keloid and hypertrophic scar formation. Mol Med Today. 4:19–24. 1998. View Article : Google Scholar : PubMed/NCBI

31 

Zhang Q, Oh CK, Messadi DV, et al: Hypoxia-induced HIF-1 alpha accumulation is augmented in a co-culture of keloid fibroblasts and human mast cells: involvement of ERK1/2 and PI-3K/Akt. Exp Cell Res. 312:145–155. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Harty M, Neff AW, King MW and Mescher AL: Regeneration or scarring: an immunologic perspective. Dev Dyn. 226:268–279. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Makino S, Mitsutake N, Nakashima M, et al: DHMEQ, a novel NF-kappaB inhibitor, suppresses growth and type I collagen accumulation in keloid fibroblasts. J Dermatol Sci. 51:171–180. 2008. View Article : Google Scholar : PubMed/NCBI

34 

De Bosscher K, Schmitz ML, Vanden Berghe W, et al: Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation. Proc Natl Acad Sci USA. 94:13504–13509. 1997.

35 

Yin MJ, Yamamoto Y and Gaynor RB: The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β. Nature. 396:77–80. 1998.

36 

Gilmore TD and Herscovitch M: Inhibitors of NF-kappaB signaling: 785 and counting. Oncogene. 25:6887–6899. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dong X, Mao S and Wen H: Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review). Biomed Rep 1: 833-836, 2013.
APA
Dong, X., Mao, S., & Wen, H. (2013). Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review). Biomedical Reports, 1, 833-836. https://doi.org/10.3892/br.2013.169
MLA
Dong, X., Mao, S., Wen, H."Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review)". Biomedical Reports 1.6 (2013): 833-836.
Chicago
Dong, X., Mao, S., Wen, H."Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review)". Biomedical Reports 1, no. 6 (2013): 833-836. https://doi.org/10.3892/br.2013.169
Copy and paste a formatted citation
x
Spandidos Publications style
Dong X, Mao S and Wen H: Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review). Biomed Rep 1: 833-836, 2013.
APA
Dong, X., Mao, S., & Wen, H. (2013). Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review). Biomedical Reports, 1, 833-836. https://doi.org/10.3892/br.2013.169
MLA
Dong, X., Mao, S., Wen, H."Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review)". Biomedical Reports 1.6 (2013): 833-836.
Chicago
Dong, X., Mao, S., Wen, H."Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review)". Biomedical Reports 1, no. 6 (2013): 833-836. https://doi.org/10.3892/br.2013.169
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