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Article

Association between polymorphisms of the α-kinase 1 gene and type 2 diabetes mellitus in community‑dwelling individuals

  • Authors:
    • Shigetaka Shimokata
    • Mitsutoshi Oguri
    • Tetsuo Fujimaki
    • Hideki Horibe
    • Kimihiko Kato
    • Yoshiji Yamada
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Aichi, Japan, Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Mie, Japan, Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan, Meitoh Hospital, Nagoya, Aichi, Japan, Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie, Japan
  • Pages: 940-944
    |
    Published online on: September 25, 2013
       https://doi.org/10.3892/br.2013.173
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Abstract

We previously demonstrated that the α‑kinase 1 gene (ALPK1) is a susceptibility locus for chronic kidney disease in individuals with diabetes mellitus (DM) by a genome‑wide association study. Although genetic variants of ALPK1 have been associated with chronic kidney disease in individuals with DM, whether ALPK1 is a susceptibility locus for DM has not been elucidated. The purpose of the present study was to investigate a possible association of the rs2074388 (A→G, Asp565Gly) or rs2074379 (A→G, Ile732Met) variants of ALPK1 with type 2 DM in community‑dwelling individuals. The study subjects comprised 5,959 community‑dwelling individuals (495 subjects with type 2 DM and 5,464 controls) who were recruited to a population‑based cohort study in Inabe, Mie, Japan. The comparisons of allele frequencies or genotype distributions using the chi‑square test revealed that the rs2074388 and rs2074379 variants of ALPK1 were significantly associated with type 2 DM (P<0.05). A multivariable logistic regression analysis with adjustment for age, gender, body mass index and smoking status revealed that the rs2074388 (P=0.0051; odds ratio, 1.32) and rs2074379 (P=0.0058; odds ratio, 1.32) variants were significantly associated with type 2 DM. The haplotype analysis of these polymorphisms revealed that the frequency of the major haplotype, A (rs2074388)‑A (rs2074379), was significantly lower, whereas that of the minor haplotype G‑G was significantly higher in subjects with type 2 DM compared to controls. thus, ALPK1 may be a susceptible gene for type 2 DM in community‑dwelling Japanese individuals.
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Copy and paste a formatted citation
Spandidos Publications style
Shimokata S, Oguri M, Fujimaki T, Horibe H, Kato K and Yamada Y: Association between polymorphisms of the α-kinase 1 gene and type 2 diabetes mellitus in community‑dwelling individuals. Biomed Rep 1: 940-944, 2013.
APA
Shimokata, S., Oguri, M., Fujimaki, T., Horibe, H., Kato, K., & Yamada, Y. (2013). Association between polymorphisms of the α-kinase 1 gene and type 2 diabetes mellitus in community‑dwelling individuals. Biomedical Reports, 1, 940-944. https://doi.org/10.3892/br.2013.173
MLA
Shimokata, S., Oguri, M., Fujimaki, T., Horibe, H., Kato, K., Yamada, Y."Association between polymorphisms of the α-kinase 1 gene and type 2 diabetes mellitus in community‑dwelling individuals". Biomedical Reports 1.6 (2013): 940-944.
Chicago
Shimokata, S., Oguri, M., Fujimaki, T., Horibe, H., Kato, K., Yamada, Y."Association between polymorphisms of the α-kinase 1 gene and type 2 diabetes mellitus in community‑dwelling individuals". Biomedical Reports 1, no. 6 (2013): 940-944. https://doi.org/10.3892/br.2013.173
Copy and paste a formatted citation
x
Spandidos Publications style
Shimokata S, Oguri M, Fujimaki T, Horibe H, Kato K and Yamada Y: Association between polymorphisms of the α-kinase 1 gene and type 2 diabetes mellitus in community‑dwelling individuals. Biomed Rep 1: 940-944, 2013.
APA
Shimokata, S., Oguri, M., Fujimaki, T., Horibe, H., Kato, K., & Yamada, Y. (2013). Association between polymorphisms of the α-kinase 1 gene and type 2 diabetes mellitus in community‑dwelling individuals. Biomedical Reports, 1, 940-944. https://doi.org/10.3892/br.2013.173
MLA
Shimokata, S., Oguri, M., Fujimaki, T., Horibe, H., Kato, K., Yamada, Y."Association between polymorphisms of the α-kinase 1 gene and type 2 diabetes mellitus in community‑dwelling individuals". Biomedical Reports 1.6 (2013): 940-944.
Chicago
Shimokata, S., Oguri, M., Fujimaki, T., Horibe, H., Kato, K., Yamada, Y."Association between polymorphisms of the α-kinase 1 gene and type 2 diabetes mellitus in community‑dwelling individuals". Biomedical Reports 1, no. 6 (2013): 940-944. https://doi.org/10.3892/br.2013.173
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