Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
January-February 2014 Volume 2 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-February 2014 Volume 2 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin‑induced diabetes in rats

  • Authors:
    • Xiaofei Si
    • Peng Li
    • Yan Zhang
    • Wei Lv
    • Dong Qi
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P.R. China, Yantai Yu Huang Ding Hospital, Yantai, Shandong 264000, P.R. China, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong 264005, P.R. China
  • Pages: 24-28
    |
    Published online on: October 9, 2013
       https://doi.org/10.3892/br.2013.183
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Olmesartan medoxomil (OM) is one of the newest members of the angiotensin receptor blocker (ARB) family. The renoprotective effects of the angiotensin II type 1 receptor antagonist OM was investigated in a streptozotocin (STZ)‑induced diabetic rat model. In this study, we investigated whether OM was able to ameliorate diabetic nephropathy (DN). Thirty male Sprague Dawley rats were assigned to 3 groups: the non‑diabetic (group A, n=10), the untreated STZ‑induced DN control (group B, n=10) and the STZ‑induced DN treated with OM (group C, n=10). Blood pressure (BP) and glucose, creatinine (Cr), blood urea nitrogen (BUN), superoxide dismutase (SOD), malondialdehyde (MDA) microalbumin and urinary protein concentrations were measured. In STZ diabetic rats, BP, glucose, Cr, BUN, MDA and urinary protein levels were significantly increased compared to the non‑diabetic control group. OM significantly improved the biological indices in the DN rats. The renal pathological changes were also observed under a light microscope. Our results suggested that OM exerted renoprotective effects on rats with STZ‑induced diabetes.
View Figures

Figure 1

Figure 2

View References

1 

Wild S, Roglic G, Green A, Sicree R and King H: Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 27:1047–1053. 2004.PubMed/NCBI

2 

Tan AL, Forbes JM and Cooper ME: AGE, RAGE, and ROS in diabetic nephropathy. Semin Nephrol. 27:130–143. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Dalla Vestra M, Saller A, Bortoloso E, Mauer M and Fioretto P: Structural involvement in type 1 and type 2 diabetic nephropathy. Diabetes Metab. 26(Suppl 4): 8–14. 2000.PubMed/NCBI

4 

American Diabetes Association. Standards of medical care in diabetes. Diabetes Care. 28(Suppl 1): 4–36. 2005. View Article : Google Scholar

5 

Ritz E, Rychlik I, Locatelli F and Halimi S: End-stage renal failure in type 2 diabetes: a medical catastrophe of worldwide dimensions. Am J Kidney Dis. 34:795–808. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Pugsley MK: The angiotensin-II (AT-II) receptor blocker olmesartan reduces renal damage in animal models of hypertension and diabetes. Proc West Pharmacol Soc. 48:35–38. 2005.PubMed/NCBI

7 

de Gasparo M, Catt KJ, Inagami T, Wright JW and Unger T: International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 52:415–472. 2000.PubMed/NCBI

8 

Kohzuki M, Yasujima M, Kanazawa M, et al: Antihypertensive and renal-protective effects of losartan in streptozotocin diabetic rats. J Hypertens. 13:97–103. 1995. View Article : Google Scholar : PubMed/NCBI

9 

Uehara Y, Hirawa N, Kawabata Y, et al: Angiotensin II subtype-1 receptor antagonists improve hemodynamic and renal changes without affecting glucose metabolisms in genetic rat model of non-insulin-dependent diabetes mellitus. Am J Hypertens. 12:21–27. 1999. View Article : Google Scholar

10 

Yao L, Kobori H, Rahman M, et al: Olmesartan improves endothelin-induced hypertension and oxidative stress in rats. Hypertens Res. 27:493–500. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Adams AJ: Bench to bedside and bedside to bench: where are we? Optom Vis Sci. 83:125–126. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Kelly A, Li C, Gao Z, Stanley CA and Matschinsky FM: Glutaminolysis and insulin secretion: from bedside to bench and back. Diabetes. 51(Suppl 3): 421–426. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Dai GL, He JK, Xie Y, Han R, Qin ZH and Zhu LJ: Therapeutic potential of Naja naja atra venom in a rat model of diabetic nephropathy. Biomed Environ Sci. 25:630–638. 2012.

14 

Yamabe N, Yokozawa T, Oya T and Kim M: Therapeutic potential of (−)-epigallocatechin 3-O-gallate on renal damage in diabetic nephropathy model rats. J Pharmacol Exp Ther. 319:228–236. 2006.

15 

Ozturk Y, Altan VM and Yildizoglu-Ari N: Effects of experimental diabetes and insulin on smooth muscle functions. Pharmacol Rev. 48:69–112. 1996.PubMed/NCBI

16 

Junod A, Lambert AE, Orci L, Pictet R, Gonet AE and Renold AE: Studies of the diabetogenic action of streptozotocin. Proc Soc Exp Biol Med. 126:201–205. 1967. View Article : Google Scholar : PubMed/NCBI

17 

Jones RB, Dickinson K, Anthony DM, Marita AR, Kaul CL and Buckett WR: Evaluation of BTS 67 582, a novel antidiabetic agent, in normal and diabetic rats. Br J Pharmacol. 120:1135–1143. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Srinivasan K and Ramarao P: Animal models in type 2 diabetes research: an overview. Indian J Med Res. 125:451–472. 2007.PubMed/NCBI

19 

Kanwar YS, Wada J, Sun L, et al: Diabetic nephropathy: mechanisms of renal disease progression. Exp Biol Med (Maywood). 233:4–11. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Nakagawa T, Sato W, Glushakova O, et al: Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy. J Am Soc Nephrol. 18:539–550. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Ota T, Takamura T, Ando H, Nohara E, Yamashita H and Kobayashi K: Preventive effect of cerivastatin on diabetic nephropathy through suppression of glomerular macrophage recruitment in a rat model. Diabetologia. 46:843–851. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Oktem F, Ozguner F, Yilmaz HR, Uz E and Dundar B: Melatonin reduces urinary excretion of N-acetyl-beta-D-glucosaminidase, albumin and renal oxidative markers in diabetic rats. Clin Exp Pharmacol Physiol. 33:95–101. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Lewis EJ, Hunsicker LG, Bain RP and Rohde RD: The effect of angiotensin-converting enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med. 329:1456–1462. 1993. View Article : Google Scholar : PubMed/NCBI

24 

Noda M, Matsuo T, Fukuda R, et al: Effect of candesartan cilexetil (TCV-116) in rats with chronic renal failure. Kidney Int. 56:898–909. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Ueno T, Kaname S, Takaichi K, et al: LOX-1, an oxidized low-density lipoprotein receptor, was upregulated in the kidneys of chronic renal failure rats. Hypertens Res. 26:117–122. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Zhou A, Yu L, Li J, Zhang J and Wang H: Renal protective effects of blocking the intrarenal renin-angiotensin system: angiotensin II type I receptor antagonist compared with angiotensin-converting enzyme inhibitor. Hypertens Res. 23:391–397. 2000. View Article : Google Scholar

27 

Tabaei BP, Al-Kassab AS, Ilag LL, Zawacki CM and Herman WH: Does microalbuminuria predict diabetic nephropathy? Diabetes Care. 24:1560–1566. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Inada Y, Murakami M, Tazawa S and Akahane M: KRH-594, a new angiotensin AT1 receptor antagonist, ameliorates nephropathy and hyperlipidaemia in diabetic spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 27:270–276. 2000. View Article : Google Scholar

29 

Baynes JW and Thorpe SR: Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes. 48:1–9. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Fujimoto S, Satoh M, Horike H, et al: Olmesartan ameliorates progressive glomerular injury in subtotal nephrectomized rats through suppression of superoxide production. Hypertens Res. 31:305–313. 2008. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Si X, Li P, Zhang Y, Lv W and Qi D: Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin‑induced diabetes in rats. Biomed Rep 2: 24-28, 2014.
APA
Si, X., Li, P., Zhang, Y., Lv, W., & Qi, D. (2014). Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin‑induced diabetes in rats. Biomedical Reports, 2, 24-28. https://doi.org/10.3892/br.2013.183
MLA
Si, X., Li, P., Zhang, Y., Lv, W., Qi, D."Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin‑induced diabetes in rats". Biomedical Reports 2.1 (2014): 24-28.
Chicago
Si, X., Li, P., Zhang, Y., Lv, W., Qi, D."Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin‑induced diabetes in rats". Biomedical Reports 2, no. 1 (2014): 24-28. https://doi.org/10.3892/br.2013.183
Copy and paste a formatted citation
x
Spandidos Publications style
Si X, Li P, Zhang Y, Lv W and Qi D: Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin‑induced diabetes in rats. Biomed Rep 2: 24-28, 2014.
APA
Si, X., Li, P., Zhang, Y., Lv, W., & Qi, D. (2014). Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin‑induced diabetes in rats. Biomedical Reports, 2, 24-28. https://doi.org/10.3892/br.2013.183
MLA
Si, X., Li, P., Zhang, Y., Lv, W., Qi, D."Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin‑induced diabetes in rats". Biomedical Reports 2.1 (2014): 24-28.
Chicago
Si, X., Li, P., Zhang, Y., Lv, W., Qi, D."Renoprotective effects of olmesartan medoxomil on diabetic nephropathy in streptozotocin‑induced diabetes in rats". Biomedical Reports 2, no. 1 (2014): 24-28. https://doi.org/10.3892/br.2013.183
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team