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Article

Association of ultraviolet radiation resistance‑associated gene polymorphisms with rheumatoid arthritis

  • Authors:
    • Hyung‑Ki Kim
    • Wha‑Young Lee
    • Jun‑Tack Kwon
    • Dong‑Ryul Sohn
    • Seung‑Jae Hong
    • Hak‑Jae Kim
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea, Soonchunhyang Medical Research Institute, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
  • Pages: 117-121
    |
    Published online on: October 21, 2013
       https://doi.org/10.3892/br.2013.185
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Abstract

The ultraviolet radiation resistance‑associated gene (UVRAG) protein binds to the Beclin 1̸PI3‑kinase III complex and promotes autophagy. Autophagy may be upregulated by endoplasmic reticulum (ER) stress. Persistent and excessive ER stress may alter synovial fibroblast apoptosis and this alteration may affect the pathogenesis of rheumatoid arthritis (RA). In this study, we investigated whether UVRAG genetic polymorphisms are associated with RA. To determine the association between UVRAG polymorphisms and RA, we genotyped five UVRAG single‑nucleotide polymorphisms (SNPs; rs7111334, intron C̸T; rs7933235, intron A̸G; rs1380075, intron T̸A; rs1458836, near the 5' gene terminal G̸A; and rs636420, exon 15 C̸T) using a direct sequencing method in 243 RA patients and 417 control subjects. Among these, one SNP (rs7111334) exhibited significant genotypic̸allelic differences between RA patients and the control group. Therefore, this study suggested a possible association between UVRAG polymorphisms and RA susceptibility.
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Copy and paste a formatted citation
Spandidos Publications style
Kim HK, Lee WY, Kwon JT, Sohn DR, Hong SJ and Kim HJ: Association of ultraviolet radiation resistance‑associated gene polymorphisms with rheumatoid arthritis. Biomed Rep 2: 117-121, 2014.
APA
Kim, H., Lee, W., Kwon, J., Sohn, D., Hong, S., & Kim, H. (2014). Association of ultraviolet radiation resistance‑associated gene polymorphisms with rheumatoid arthritis. Biomedical Reports, 2, 117-121. https://doi.org/10.3892/br.2013.185
MLA
Kim, H., Lee, W., Kwon, J., Sohn, D., Hong, S., Kim, H."Association of ultraviolet radiation resistance‑associated gene polymorphisms with rheumatoid arthritis". Biomedical Reports 2.1 (2014): 117-121.
Chicago
Kim, H., Lee, W., Kwon, J., Sohn, D., Hong, S., Kim, H."Association of ultraviolet radiation resistance‑associated gene polymorphisms with rheumatoid arthritis". Biomedical Reports 2, no. 1 (2014): 117-121. https://doi.org/10.3892/br.2013.185
Copy and paste a formatted citation
x
Spandidos Publications style
Kim HK, Lee WY, Kwon JT, Sohn DR, Hong SJ and Kim HJ: Association of ultraviolet radiation resistance‑associated gene polymorphisms with rheumatoid arthritis. Biomed Rep 2: 117-121, 2014.
APA
Kim, H., Lee, W., Kwon, J., Sohn, D., Hong, S., & Kim, H. (2014). Association of ultraviolet radiation resistance‑associated gene polymorphisms with rheumatoid arthritis. Biomedical Reports, 2, 117-121. https://doi.org/10.3892/br.2013.185
MLA
Kim, H., Lee, W., Kwon, J., Sohn, D., Hong, S., Kim, H."Association of ultraviolet radiation resistance‑associated gene polymorphisms with rheumatoid arthritis". Biomedical Reports 2.1 (2014): 117-121.
Chicago
Kim, H., Lee, W., Kwon, J., Sohn, D., Hong, S., Kim, H."Association of ultraviolet radiation resistance‑associated gene polymorphisms with rheumatoid arthritis". Biomedical Reports 2, no. 1 (2014): 117-121. https://doi.org/10.3892/br.2013.185
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