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Article

In vivo and in vitro antimalarial activity of bergenin

  • Authors:
    • Jiao Liang
    • Yinghui Li
    • Xuewu Liu
    • Yuxiao Huang
    • Yan Shen
    • Jun Wang
    • Zhongxiang Liu
    • Ya Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Microbiology and Parasitology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China
  • Pages: 260-264
    |
    Published online on: November 25, 2013
       https://doi.org/10.3892/br.2013.207
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Abstract

Malaria is a potentially life-threatening protozoal parasitic disease transmitted by female Anopheles mosquitoes. Drug therapy is currently the most widely used method for the control and treatment of this disease. Several plants were found to contain substances possessing antimalarial properties. In this study, we investigated the antimalarial activity of bergenin, a sesquiterpene lactone compound derived from Rodgersia aesculifolia Batal. The results indicated that bergenin effectively inhibited Plasmodium falciparum growth in vitro (IC50, 14.1 µg̸ml, with ~100% inhibition at 50 µg/ml), without apparent cytotoxicity to erythrocytes or to mammalian HeLa and HepG2 cells. bergenin exhibited less cytotoxic activity and the selectivity index (SI) was 887 and 1,355 for HeLa and HepG2 cells, respectively. The administration of bergenin to Plasmodium berghei‑infected mice for 6 days significantly inhibited the growth of the parasites. Taken together, these findings provide evidence that bergenin may be a promising novel drug for antimalarial treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Liang J, Li Y, Liu X, Huang Y, Shen Y, Wang J, Liu Z and Zhao Y: In vivo and in vitro antimalarial activity of bergenin. Biomed Rep 2: 260-264, 2014.
APA
Liang, J., Li, Y., Liu, X., Huang, Y., Shen, Y., Wang, J. ... Zhao, Y. (2014). In vivo and in vitro antimalarial activity of bergenin. Biomedical Reports, 2, 260-264. https://doi.org/10.3892/br.2013.207
MLA
Liang, J., Li, Y., Liu, X., Huang, Y., Shen, Y., Wang, J., Liu, Z., Zhao, Y."In vivo and in vitro antimalarial activity of bergenin". Biomedical Reports 2.2 (2014): 260-264.
Chicago
Liang, J., Li, Y., Liu, X., Huang, Y., Shen, Y., Wang, J., Liu, Z., Zhao, Y."In vivo and in vitro antimalarial activity of bergenin". Biomedical Reports 2, no. 2 (2014): 260-264. https://doi.org/10.3892/br.2013.207
Copy and paste a formatted citation
x
Spandidos Publications style
Liang J, Li Y, Liu X, Huang Y, Shen Y, Wang J, Liu Z and Zhao Y: In vivo and in vitro antimalarial activity of bergenin. Biomed Rep 2: 260-264, 2014.
APA
Liang, J., Li, Y., Liu, X., Huang, Y., Shen, Y., Wang, J. ... Zhao, Y. (2014). In vivo and in vitro antimalarial activity of bergenin. Biomedical Reports, 2, 260-264. https://doi.org/10.3892/br.2013.207
MLA
Liang, J., Li, Y., Liu, X., Huang, Y., Shen, Y., Wang, J., Liu, Z., Zhao, Y."In vivo and in vitro antimalarial activity of bergenin". Biomedical Reports 2.2 (2014): 260-264.
Chicago
Liang, J., Li, Y., Liu, X., Huang, Y., Shen, Y., Wang, J., Liu, Z., Zhao, Y."In vivo and in vitro antimalarial activity of bergenin". Biomedical Reports 2, no. 2 (2014): 260-264. https://doi.org/10.3892/br.2013.207
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