Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
March-April 2014 Volume 2 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-April 2014 Volume 2 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of ‑108 C>T PON1 polymorphism with polycystic ovary syndrome

  • Authors:
    • Polonca Ferk
    • Ksenija Gersak
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Maribor, Maribor, Slovenia, Department of Obstetrics and Gynaecology, Ljubljana University Medical Centre, Ljubljana, Slovenia
  • Pages: 255-259
    |
    Published online on: December 30, 2013
       https://doi.org/10.3892/br.2013.214
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

Polycystic ovary syndrome (PCOS) is possibly the most common endocrine disorder in premenopausal women. in this study, we aimed to investigate the association of the ‑108 C>T polymorphism in the PON1 gene, which encodes the antioxidant enzyme paraoxonase‑1, with PCOS. A total of 118 women with PCOS and 108 control subjects were included in this case‑control study. the PON1 polymorphism was genotyped, biochemical and clinical parameters were determined and the correlations between the parameters were statistically evaluated. The differences in the PON1 allele and genotype distributions between PCOS patients and controls did not reach a statistical significance. The serum fasting glucose (GLU) levels did not differ significantly between the PCOS patients and the controls. However, the serum fasting insulin (INS) concentration, INS̸GLU ratio and homeostasis model assessment (HOMA) index, although within the normal range, were significantly higher in the PCOS group. When considering PCOS patients and controls as separate groups or as a single group of patients, none of the analyzed biochemical or clinical parameters were found to be significantly correlated with the PON1 polymorphism. Therefore, the ‑108 C>T PON1 polymorphism was not found to be significantly associated with the presence of PCOS or with its particular clinical and biochemical characteristics in non‑insulin resistant, non‑obese patients.
View Figures

Figure 1

View References

1 

Homburg R: What is polycystic ovarian syndrome? A proposal for a consensus on the definition and diagnosis of polycystic ovarian syndrome. Hum Reprod. 17:2495–2499. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Homburg R: The management of infertility associated with polycystic ovary syndrome. Reprod Biol Endocrinol. 1:1092003. View Article : Google Scholar : PubMed/NCBI

3 

Diamanti-Kandarakis E, Piperi C, Spina J, Argyrakopoulou G, Papanastasiou L, Bergiele A and Panidis D: Polycystic ovary syndrome: the influence of environmental and genetic factors. Hormones (Athens). 5:17–34. 2006. View Article : Google Scholar

4 

Mukherjee S and Maitra A: Molecular and genetic factors contributing to insulin resistance in polycystic ovary syndrome. Indian J Med Res. 131:743–760. 2010.PubMed/NCBI

5 

Prapas N, Karkanaki A, Prapas I, Kalogiannidis I, Katsikis I and Panidis D: Genetics of polycystic ovary syndrome. Hippokratia. 13:216–223. 2009.PubMed/NCBI

6 

Lenarcik A, Bidzinska-Speichert B and Tworowska-Bardzinska U: The role of chronic inflammation and Leu55Met PON1 polymorphism in the pathogenesis of polycystic ovary syndrome. Gynecol Endocrinol. 26:673–683. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Luque-Ramirez M, San Millan JL and Escobar-Morreale HF: Genomic variants in polycystic ovary syndrome. Clin Chim Acta. 366:14–26. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Martinez-Garcia MA, Luque-Ramirez M, San-Millan JL and Escobar-Morreale HF: Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism. Diabetes Care. 32:1525–1530. 2009. View Article : Google Scholar

9 

San Millan JL, Alvarez-Blasco F, Luque-Ramirez M, Botella-Carretero JI and Escobar-Morreale HF: The PON1-108C/T polymorphism, and not the polycystic ovary syndrome, is an important determinant of reduced serum paraoxonase activity in premenopausal women. Hum Reprod. 21:3157–3161. 2006.PubMed/NCBI

10 

Mohamadin AM, Habib FA and Elahi TF: Serum paraoxonase 1 activity and oxidant/antioxidant status in Saudi women with polycystic ovary syndrome. Pathophysiology. 17:189–196. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Fenkci IV, Serteser M, Fenkci S and Kose S: Paraoxonase levels in women with polycystic ovary syndrome. J Reprod Med. 52:879–883. 2007.PubMed/NCBI

12 

Dursun P, Demirtas E, Bayrak A and Yarali H: Decreased serum paraoxonase 1 (PON1) activity: an additional risk factor for atherosclerotic heart disease in patients with PCOS? Hum Reprod. 21:104–108. 2006. View Article : Google Scholar : PubMed/NCBI

13 

San Millan JL, Corton M, Villuendas G, Sancho J, Peral B and Escobar-Morreale HF: Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity. J Clin Endocrinol Metab. 89:2640–2646. 2004.PubMed/NCBI

14 

Brophy VH, Jampsa RL, Clendenning JB, McKinstry LA, Jarvik GP and Furlong CE: Effects of 5′ regulatory-region polymorphisms on paraoxonase-gene (PON1) expression. Am J Hum Genet. 68:1428–1436. 2001.

15 

Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 81:19–25. 2004. View Article : Google Scholar

16 

Balen AH, Laven JS, Tan SL and Dewailly D: Ultrasound assessment of the polycystic ovary: international consensus definitions. Hum Reprod Update. 9:505–514. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Ly LP and Handelsman DJ: Empirical estimation of free testosterone from testosterone and sex hormone-binding globulin immunoassays. Eur J Endocrinol. 152:471–478. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Ferk P, Perme MP and Gersak K: Insulin gene polymorphism in women with polycystic ovary syndrome. J Int Med Res. 36:1180–1187. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Soyman Z, Noyan V, Tulmac M, Yucel A, Sagsoz N, Bayrak T and Cakir E: Serum paraoxonase 1 activity, asymmetric dimethylarginine levels, and brachial artery flow-mediated dilatation in women with polycystic ovary syndrome. Fertil Steril. 95:1067–1072. 2011. View Article : Google Scholar

20 

Leviev I, Kalix B, Brulhart Meynet MC and James RW: The paraoxonase PON1 promoter polymorphism C(-107)T is associated with increased serum glucose concentrations in non-diabetic patients. Diabetologia. 44:1177–1183. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Zhang F, Liu HW, Fan P, Bai H and Song Q: The -108 C/T polymorphism in paraoxonase 1 gene in Chinese patients with polycystic ovary syndrome. J Sichuan Univ Med Sci Ed. 42:24–28. 2011.(In Chinese).

22 

Torun AN, Vural M, Cece H, Camuzcuoglu H, Toy H and Aksoy N: Paraoxonase-1 is not affected in polycystic ovary syndrome without metabolic syndrome and insulin resistance, but oxidative stress is altered. Gynecol Endocrinol. 27:988–992. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Hughes C, Elgasim M, Layfield R and Atiomo W: Genomic and post-genomic approaches to polycystic ovary syndrome - progress so far: Mini Review. Hum Reprod. 21:2766–2775. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Simoni M, Tempfer CB, Destenaves B and Fauser BC: Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response. Hum Reprod Update. 14:459–484. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Lander ES and Schork NJ: Genetic dissection of complex traits. Science. 265:2037–2048. 1994. View Article : Google Scholar : PubMed/NCBI

26 

Unluturk U, Harmanci A, Kocaefe C and Yildiz BO: The genetic basis of the polycystic ovary syndrome: a literature review including discussion of PPAR-gamma. PPAR Res. 2007:491092007. View Article : Google Scholar : PubMed/NCBI

27 

Skerget AE, Herodez SS, Zagorac A, Zagradisnik B and Vokac NK: The use of comparative genomic hybridization as a diagnostic tool in medical genetics laboratories: first application on different clinical samples. Acta Medico-Biotechnica. 4:49–56. 2011.

28 

Goodarzi MO: Looking for polycystic ovary syndrome genes: rational and best strategy. Semin Reprod Med. 26:5–13. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Pasquali R, Stener-Victorin E, Yildiz BO, et al: PCOS Forum: research in polycystic ovary syndrome today and tomorrow. Clin Endocrinol (Oxf). 74:424–433. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ferk P and Gersak K: Association of ‑108 C>T PON1 polymorphism with polycystic ovary syndrome. Biomed Rep 2: 255-259, 2014.
APA
Ferk, P., & Gersak, K. (2014). Association of ‑108 C>T PON1 polymorphism with polycystic ovary syndrome. Biomedical Reports, 2, 255-259. https://doi.org/10.3892/br.2013.214
MLA
Ferk, P., Gersak, K."Association of ‑108 C>T PON1 polymorphism with polycystic ovary syndrome". Biomedical Reports 2.2 (2014): 255-259.
Chicago
Ferk, P., Gersak, K."Association of ‑108 C>T PON1 polymorphism with polycystic ovary syndrome". Biomedical Reports 2, no. 2 (2014): 255-259. https://doi.org/10.3892/br.2013.214
Copy and paste a formatted citation
x
Spandidos Publications style
Ferk P and Gersak K: Association of ‑108 C>T PON1 polymorphism with polycystic ovary syndrome. Biomed Rep 2: 255-259, 2014.
APA
Ferk, P., & Gersak, K. (2014). Association of ‑108 C>T PON1 polymorphism with polycystic ovary syndrome. Biomedical Reports, 2, 255-259. https://doi.org/10.3892/br.2013.214
MLA
Ferk, P., Gersak, K."Association of ‑108 C>T PON1 polymorphism with polycystic ovary syndrome". Biomedical Reports 2.2 (2014): 255-259.
Chicago
Ferk, P., Gersak, K."Association of ‑108 C>T PON1 polymorphism with polycystic ovary syndrome". Biomedical Reports 2, no. 2 (2014): 255-259. https://doi.org/10.3892/br.2013.214
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team