|
1
|
Rotterdam ESHRE/ASRM-Sponsored PCOS
consensus workshop group. Revised 2003 consensus on diagnostic
criteria and long-term health risks related to polycystic ovary
syndrome (PCOS). Hum Reprod. 19:41–47. 2004. View Article : Google Scholar
|
|
2
|
Diamanti-Kandarakis E and Piperi C:
Genetics of polycystic ovary syndrome: searching for the way out of
the labyrinth. Hum Reprod Update. 11:631–643. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Alberti KG, Zimmet P and Shaw J:
International Diabetes Federation: a consensus on Type 2 diabetes
prevention. Diabet Med. 24:451–463. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Carmina E, Orio F, Palomba S, et al:
Evidence for altered adipocyte function in polycystic ovary
syndrome. Eur J Endocrinol. 152:389–394. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Ehrmann DA, Barnes RB, Rosenfield RL,
Cavaghan MK and Imperial J: Prevalence of impaired glucose
tolerance and diabetes in women with polycystic ovary syndrome.
Diabetes Care. 22:141–146. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Schmidt J, Landin-Wilhelmsen K, Brannstrom
M and Dahlgren E: Cardiovascular disease and risk factors in PCOS
women of postmenopausal age: a 21-year controlled follow-up study.
J Clin Endocrinol Metab. 96:3794–3803. 2011.PubMed/NCBI
|
|
7
|
Kadowaki T, Hara K, Kubota N, et al: The
role of PPARgamma in high-fat diet-induced obesity and insulin
resistance. J Diabetes Complications. 16:41–45. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Zhang J, Fu M, Cui T, et al: Selective
disruption of PPARgamma 2 impairs the development of adipose tissue
and insulin sensitivity. Proc Natl Acad Sci USA. 101:10703–10708.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Elbrecht A, Chen Y, Cullinan CA, et al:
Molecular cloning, expression and characterization of human
peroxisome proliferator activated receptors gamma 1 and gamma 2.
Biochem Biophys Res Commun. 224:431–437. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Rangwala SM and Lazar MA: Peroxisome
proliferator-activated receptor gamma in diabetes and metabolism.
Trends Pharmacol Sci. 25:331–336. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Deeb SS, Fajas L, Nemoto M, et al: A
Pro12Ala substitution in PPARgamma2 associated with decreased
receptor activity, lower body mass index and improved insulin
sensitivity. Nat Genet. 20:284–287. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Altshuler D, Hirschhorn JN, Klannemark M,
et al: The common PPARgamma Pro12Ala polymorphism is associated
with decreased risk of type 2 diabetes. Nat Genet. 26:76–80. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Hara K, Okada T, Tobe K, et al: The
Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type
2 diabetes. Biochem Biophys Res Commun. 271:212–216. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Jacob S, Stumvoll M, Becker R, et al: The
PPARgamma2 polymorphism pro12Ala is associated with better insulin
sensitivity in the offspring of type 2 diabetic patients. Horm
Metab Res. 32:413–416. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Doney AS, Fischer B, Leese G, Morris AD
and Palmer CN: Cardiovascular risk in type 2 diabetes is associated
with variation at the PPARG locus: a Go-DARTS study. Arterioscler
Thromb Vasc Biol. 24:2403–2407. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Demers A, Caron V, Rodrigue-Way A, Wahli
W, Ong H and Tremblay A: A concerted kinase interplay identifies
PPARgamma as a molecular target of ghrelin signaling in
macrophages. PLoS One. 4:e77282009. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Haseeb A, Iliyas M, Chakrabarti S, et al:
Single-nucleotide polymorphisms in peroxisome
proliferator-activated receptor gamma and their association with
plasma levels of resistin and the metabolic syndrome in a South
Indian population. J Biosci. 34:405–414. 2009. View Article : Google Scholar
|
|
18
|
Simon I, Vendrell J, Gutierrez C, et al:
Pro12Ala substitution in the peroxisome proliferator-activated
receptor-gamma is associated with increased leptin levels in women
with type-2 diabetes mellitus. Horm Res. 58:143–149. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Yamamoto Y, Hirose H, Miyashita K, et al:
PPAR(gamma)2 gene Pro12Ala polymorphism may influence serum level
of an adipocyte-derived protein, adiponectin, in the Japanese
population. Metabolism. 51:1407–1409. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Baldani DP, Skrgatic L, Goldstajn MS, et
al: Clinical and biochemical characteristics of polycystic ovary
syndrome in Croatian population. Coll Antropol. 36:1413–1418.
2012.PubMed/NCBI
|
|
21
|
Ferriman D and Gallwey JD: Clinical
assessment of body hair growth in women. J Clin Endocrinol Metab.
21:1440–1447. 1961. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Vermeulen A, Verdonck L and Kaufman JM: A
critical evaluation of simple methods for the estimation of free
testosterone in serum. J Clin Endocrinol Metab. 84:3666–3672. 1999.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Friedewald WT, Levy RI and Fredrickson DS:
Estimation of the concentration of low-density lipoprotein
cholesterol in plasma, without use of the preparative
ultracentrifuge. Clin Chem. 18:499–502. 1972.PubMed/NCBI
|
|
24
|
Hara M, Alcoser SY, Qaadir A, Beiswenger
KK, Cox NJ and Ehrmann DA: Insulin resistance is attenuated in
women with polycystic ovary syndrome with the Pro(12)Ala
polymorphism in the PPARgamma gene. J Clin Endocrinol Metab.
87:772–775. 2002.PubMed/NCBI
|
|
25
|
Korhonen S, Heinonen S, Hiltunen M, et al:
Polymorphism in the peroxisome proliferator-activated
receptor-gamma gene in women with polycystic ovary syndrome. Hum
Reprod. 18:540–543. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Yilmaz M, Ergun MA, Karakoc A, Yurtcu E,
Cakir N and Arslan M: Pro12Ala polymorphism of the peroxisome
proliferator-activated receptor-gamma gene in women with polycystic
ovary syndrome. Gynecol Endocrinol. 22:336–342. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Christopoulos P, Mastorakos G, Gazouli M,
et al: Peroxisome proliferator-activated receptor-gamma and -delta
polymorphisms in women with polycystic ovary syndrome. Ann NY Acad
Sci. 1205:185–191. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Hahn S, Fingerhut A, Khomtsiv U, et al:
The peroxisome proliferator activated receptor gamma Pro12Ala
polymorphism is associated with a lower hirsutism score and
increased insulin sensitivity in women with polycystic ovary
syndrome. Clin Endocrinol (Oxf). 62:573–579. 2005. View Article : Google Scholar
|
|
29
|
Koika V, Marioli DJ, Saltamavros AD, et
al: Association of the Pro12Ala polymorphism in peroxisome
proliferator-activated receptor gamma2 with decreased basic
metabolic rate in women with polycystic ovary syndrome. Eur J
Endocrinol. 161:317–322. 2009. View Article : Google Scholar
|
|
30
|
Orio F Jr, Matarese G, Di Biase S, et al:
Exon 6 and 2 peroxisome proliferator-activated receptor-gamma
polymorphisms in polycystic ovary syndrome. J Clin Endocrinol
Metab. 88:5887–5892. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Orio F Jr, Palomba S, Cascella T, et al:
Lack of an association between peroxisome proliferator-activated
receptor-gamma gene Pro12Ala polymorphism and adiponectin levels in
the polycystic ovary syndrome. J Clin Endocrinol Metab.
89:5110–5115. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
San-Millan JL and Escobar-Morreale HF: The
role of genetic variation in peroxisome proliferator-activated
receptors in the polycystic ovary syndrome (PCOS): an original
case-control study followed by systematic review and meta-analysis
of existing evidence. Clin Endocrinol (Oxf). 72:383–392. 2010.
View Article : Google Scholar
|
|
33
|
Tok EC, Aktas A, Ertunc D, Erdal EM and
Dilek S: Evaluation of glucose metabolism and reproductive hormones
in polycystic ovary syndrome on the basis of peroxisome
proliferator-activated receptor (PPAR)-gamma2 Pro12Ala genotype.
Hum Reprod. 20:1590–1595. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Xita N, Lazaros L, Georgiou I and
Tsatsoulis A: The Pro12Ala polymorphism of the PPAR-gamma gene is
not associated with the polycystic ovary syndrome. Hormones
(Athens). 8:267–272. 2009.PubMed/NCBI
|
|
35
|
He J, Wang L, Liu J, Liu F and Li X: A
meta-analysis on the association between PPAR-gamma Pro12Ala
polymorphism and polycystic ovary syndrome. J Assist Reprod Genet.
29:669–677. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Zhang H, Bi Y, Hu C, Lu W and Zhu D:
Association between the Pro12Ala polymorphism of PPAR-gamma gene
and the polycystic ovary syndrome: a meta-analysis of case-control
studies. Gene. 503:12–17. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Bidzinska-Speichert B, Demissie M,
Tworowska U, et al: Leptin level and the PPARgamma2 Pro12Ala and
Pro115Gln polymorphisms in women with functional hyperandrogenism.
Preliminary report. Przegl Lek. 62:833–837. 2005.(In Polish).
|
|
38
|
Dragojevic J, Ostanek B, Mencej-Bedrac S,
Komadina R, Prezelj J and Marc J: PPARG gene promoter polymorphism
is associated with non-traumatic hip fracture risk in the elderly
Slovenian population: a pilot study. Clin Biochem. 44:1085–1089.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Antoine HJ, Pall M, Trader BC, Chen YD,
Azziz R and Goodarzi MO: Genetic variants in peroxisome
proliferator-activated receptor gamma influence insulin resistance
and testosterone levels in normal women, but not those with
polycystic ovary syndrome. Fertil Steril. 87:862–869. 2007.
View Article : Google Scholar
|
|
40
|
Lehrke M and Lazar MA: The many faces of
PPARgamma. Cell. 123:993–999. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Ek J, Urhammer SA, Sorensen TI, Andersen
T, Auwerx J and Pedersen O: Homozygosity of the Pro12Ala variant of
the peroxisome proliferation-activated receptor-gamma2
(PPAR-gamma2): divergent modulating effects on body mass index in
obese and lean Caucasian men. Diabetologia. 42:892–895. 1999.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Kao WH, Coresh J, Shuldiner AR, et al;
Atherosclerosis Risk in Communities Study. Pro12Ala of the
peroxisome proliferator-activated receptor-gamma2 gene is
associated with lower serum insulin levels in nonobese African
Americans: the Atherosclerosis Risk in Communities Study. Diabetes.
52:1568–1572. 2003. View Article : Google Scholar
|
|
43
|
Masud S and Ye S; SAS Group. Effect of the
peroxisome proliferator activated receptor-gamma gene Pro12Ala
variant on body mass index: a meta-analysis. J Med Genet.
40:773–780. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Jaziri R, Lobbens S, Aubert R, et al;
DESIR Study Group. The PPARG Pro12Ala polymorphism is associated
with a decreased risk of developing hyperglycemia over 6 years and
combines with the effect of the APM1 G-11391A single nucleotide
polymorphism: the Data From an Epidemiological Study on the Insulin
Resistance Syndrome (DESIR) study. Diabetes. 55:1157–1162.
2006.
|
|
45
|
Huguenin GV and Rosa G: The Ala allele in
the PPAR-gamma2 gene is associated with reduced risk of type 2
diabetes mellitus in Caucasians and improved insulin sensitivity in
overweight subjects. Br J Nutr. 104:488–497. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Luan J, Browne PO, Harding AH, et al:
Evidence for gene-nutrient interaction at the PPARgamma locus.
Diabetes. 50:686–689. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Garaulet M, Smith CE, Hernandez-Gonzalez
T, Lee YC and Ordovas JM: PPARgamma Pro12Ala interacts with fat
intake for obesity and weight loss in a behavioural treatment based
on the Mediterranean diet. Mol Nutr Food Res. 55:1771–1779. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Ranilovic J, Markovina J, Znidar K and
Colic Baric I: Attitudes to healthy eating among a representative
sampling of Croatian adults: a comparison with Mediterranean
countries. Int J Food Sci Nutr. 60:11–29. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Boulman N, Levy Y, Leiba R, et al:
Increased C-reactive protein levels in the polycystic ovary
syndrome: a marker of cardiovascular disease. J Clin Endocrinol
Metab. 89:2160–2165. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Bidzinska-Speichert B, Lenarcik A,
Tworowska-Bardzinska U, et al: Pro12Ala PPAR gamma2 gene
polymorphism in women with polycystic ovary syndrome. Ginekol Pol.
82:426–429. 2011.PubMed/NCBI
|
|
51
|
Kondo H, Shimomura I, Matsukawa Y, et al:
Association of adiponectin mutation with type 2 diabetes: a
candidate gene for the insulin resistance syndrome. Diabetes.
51:2325–2328. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Kubota N, Terauchi Y, Yamauchi T, et al:
Disruption of adiponectin causes insulin resistance and neointimal
formation. J Biol Chem. 277:25863–25866. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Weyer C, Funahashi T, Tanaka S, et al:
Hypoadiponectinemia in obesity and type 2 diabetes: close
association with insulin resistance and hyperinsulinemia. J Clin
Endocrinol Metab. 86:1930–1935. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Wang C, Zhai F, Chi Y and Wang G:
Association of Pro12Ala mutation in peroxisome
proliferator-activated receptor gamma 2 with obesity and diabetes
in Chinese population. J Hyg Res. 33:317–320. 2004.(In
Chinese).
|
|
55
|
Botchkarev VA and Paus R: Molecular
biology of hair morphogenesis: development and cycling. J Exp Zool
B Mol Dev Evol. 298:164–180. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Smith KJ, Dipreta E and Skelton H:
Peroxisomes in dermatology. Part II. J Cutan Med Surg. 5:315–322.
2001. View Article : Google Scholar
|
|
57
|
Sas T, Mulder P, Aanstoot HJ, et al:
Carbohydrate metabolism during long-term growth hormone treatment
in children with short stature born small for gestational age. Clin
Endocrinol (Oxf). 54:243–251. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Leunissen RW, Oosterbeek P, Hol LK,
Hellingman AA, Stijnen T and Hokken-Koelega AC: Fat mass
accumulation during childhood determines insulin sensitivity in
early adulthood. J Clin Endocrinol Metab. 93:445–451. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Eriksson JG, Lindi V, Uusitupa M, et al:
The effects of the Pro12Ala polymorphism of the peroxisome
proliferator-activated receptor-gamma2 gene on insulin sensitivity
and insulin metabolism interact with size at birth. Diabetes.
51:2321–2324. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Ibanez L, Potau N, Francois I and de
Zegher F: Precocious pubarche, hyperinsulinism, and ovarian
hyperandrogenism in girls: relation to reduced fetal growth. J Clin
Endocrinol Metab. 83:3558–3562. 1998. View Article : Google Scholar : PubMed/NCBI
|
