Elevated serum levels of vascular endothelial growth factor is effective as a marker for malnutrition and inflammation in patients with ovarian cancer

Watanabe,Takafumi; Shibata,Masahiko; Nishiyama,Hiroshi; Soeda,Shu; Furukawa,Shigenori; Gonda,Kenji; Takenoshita,Seiichi; Fujimori,Keiya

doi:10.3892/br.2013.54

March-April 2013 Volume 1 Issue 2

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March-April 2013 Volume 1 Issue 2

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Article

Elevated serum levels of vascular endothelial growth factor is effective as a marker for malnutrition and inflammation in patients with ovarian cancer

Authors:
- Takafumi Watanabe
- Masahiko Shibata
- Hiroshi Nishiyama
- Shu Soeda
- Shigenori Furukawa
- Kenji Gonda
- Seiichi Takenoshita
- Keiya Fujimori
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Fukushima Medical University, Fukushima, Fukushima 960‑1295, Japan, Department of Tumor and Host Bioscience, Fukushima Medical University, Fukushima, Fukushima 960‑1295, Japan, Department of Organ Regulatory Surgery, Fukushima Medical University, Fukushima, Fukushima 960‑1295, Japan
Pages: 197-201
|
Published online on: January 16, 2013

https://doi.org/10.3892/br.2013.54
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Abstract

Vascular endothelial growth factor (VEGF) reportedly plays an important role in the progression of malignant neoplasms. In the present study, measured serum concentrations of VEGF were measured in patients with ovarian cancer and correlations with nutritional damage and chronic inflammation were analyzed. A significant increase in serum levels in patients compared to healthy volunteers was observed. Levels of VEGF were inversely correlated with serum concentrations of prealbumin, transferrin and retinol‑binding protein. VEGF levels were also correlated with serum levels of c‑reactive protein (CRP), an effective marker of inflammation. CRP levels were significantly elevated in patients with stage III and IV disease and inversely correlated with serum concentrations of total protein, prealbumin, transferrin and retinol‑binding protein. These results demonstrated that an increased production of VEGF correlated with nutritional impairment and inflammation.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Elevated serum levels of vascular endothelial growth factor is effective as a marker for malnutrition and inflammation in patients with ovarian cancer

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