The A10389G polymorphism of ND3 gene and breast cancer: A meta-analysis

Mao,Qunxia; Gao,Linggen; Liu,Qing; Zou,Yan; Yang,Xvhui; Wang,Hongwei; Wang,Qian; Yu,Hua

doi:10.3892/br.2013.58

March-April 2013 Volume 1 Issue 2

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

March-April 2013 Volume 1 Issue 2

Full Size Image

Article

The A10389G polymorphism of ND3 gene and breast cancer: A meta-analysis

Authors:
- Qunxia Mao
- Linggen Gao
- Qing Liu
- Yan Zou
- Xvhui Yang
- Hongwei Wang
- Qian Wang
- Hua Yu
View Affiliations / Copyright

Affiliations: National Research Institute for Family Planning, Beijing, P.R. China, Department of Geriatric Cardiology, General Hospital of Chinese People's Liberation Army, Beijing, P.R. China, Hangzhou Centre for Disease Control and Prevention, Zhejiang, P.R. China, Department of Safety Engineering, China Institute of Industrial Relations, Beijing, P.R. China, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College; Beijing, P.R. China
Pages: 259-264
|
Published online on: January 21, 2013

https://doi.org/10.3892/br.2013.58
Expand metrics +

Abstract

Previous studies have reported the association between A10389G polymorphism of the dehydrogenase subunit 3 (ND3) gene and breast cancer risk with conflicting results. To explore this association, we conducted a meta‑analysis on 5,580 patients and 5,749 controls from eligible published studies. Six reports (11 study populations) were included in this meta‑analysis. Compared with the individuals with the G allele, individuals carrying the A allele did not exhibit increased breast cancer risk. The odds ratio (OR) and 95% confidence interval (CI) were 1.02 and 0.79‑1.31, respectively. Stratified analyses were carried out according to ethnicity and source of controls. The corresponding ORs (95% CIs) were 1.20 (0.90-1.86) for African‑American, 0.47 (0.03-7.64) for European and 0.89 (0.70-1.14) for mixed populations, respectively. A single study on Asian populations yielded an OR (95% CI) of 0.56 (0.32-1.00). The corresponding ORs (95% CIs) were 1.12 (0.23-5.47) for hospital‑based studies, and 0.98 (0.76-1.27) for population‑based studies. Only one study did not mention the source of control, the OR (95% CI) of which was 1.80 (1.15-2.82). Results of the present study suggested that the ND3 gene A10389G polymorphism may not be an independent risk factor for breast cancer. However, additional studies should be performed to clarify the possible roles of the ND3 A10398G polymorphism in the etiology of breast cancer.

View Figures

View References

1	Olopade OI, Grushko TA, Nanda R and Huo D: Advances in breast cancer: pathways to personalized medicine. Clin Cancer Res. 14:7988–7999. 2008. View Article : Google Scholar : PubMed/NCBI
2	Rohan TE, Wong LJ, Wang T, et al: Do alterations in mitochondrial DNA play a role in breast carcinogenesis? J Oncol. 2010:6043042010. View Article : Google Scholar : PubMed/NCBI
3	Czarnecka AM, Krawczyk T, Zdrozny M, et al: Mitochondrial NADH-dehydrogenase subunit 3 (ND3) polymorphism (A10398G) and sporadic breast cancer in Poland. Breast Cancer Res Treat. 121:511–518. 2010. View Article : Google Scholar : PubMed/NCBI
4	Darvishi K, Sharma S, Bhat AK, et al: Mitochondrial DNA G10398A polymorphism imparts maternal Haplogroup N a risk for breast and esophageal cancer. Cancer Lett. 249:249–255. 2007. View Article : Google Scholar : PubMed/NCBI
5	Canter JA, Kallianpur AR, Parl FF and Millikan RC: Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women. Cancer Res. 65:8028–8033. 2005.
6	Wallace DC: Mitochondria as chi. Genetics. 179:727–735. 2008. View Article : Google Scholar : PubMed/NCBI
7	Bai RK, Leal SM, Covarrubias D, et al: Mitochondrial genetic background modifies breast cancer risk. Cancer Res. 67:4687–4694. 2007. View Article : Google Scholar : PubMed/NCBI
8	Aikhionbare FO, Khan M, Carey D, et al: Is cumulative frequency of mitochondrial DNA variants a biomarker for colorectal tumor progression? Mol Cancer. 3:302004. View Article : Google Scholar : PubMed/NCBI
9	Datta S, Majumder M, Biswas NK, et al: Increased risk of oral cancer in relation to common Indian mitochondrial polymorphisms and autosomal GSTP1 locus. Cancer. 110:1991–1999. 2007. View Article : Google Scholar : PubMed/NCBI
10	van der Walt JM, Nicodemus KK, Martin ER, et al: Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease. Am J Hum Genet. 72:804–811. 2003.PubMed/NCBI
11	van der Walt JM, Dementieva YA, Martin ER, et al: Analysis of European mitochondrial haplogroups with Alzheimer disease risk. Neurosci Lett. 365:28–32. 2004.PubMed/NCBI
12	Mancuso M, Conforti FL, Rocchi A, et al: Could mitochondrial haplogroups play a role in sporadic amyotrophic lateral sclerosis? Neurosci Lett. 371:158–162. 2004. View Article : Google Scholar : PubMed/NCBI
13	Giacchetti M, Monticelli A, De Biase I, et al: Mitochondrial DNA haplogroups influence the Friedreich’s ataxia phenotype. J Med Genet. 41:293–295. 2004.PubMed/NCBI
14	Wells GA, Shea B, O’Connell D, et al: The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Available from: URL: http://www.ohri.ca/programs/clinical_epidemiology/oxford.aspuri. Accessed on November 26, 2011.
15	Covarrubias D, Bai RK, Wong LJ and Leal SM: Mitochondrial DNA variant interactions modify breast cancer risk. J Hum Genet. 53:924–928. 2008. View Article : Google Scholar : PubMed/NCBI
16	Fang H, Shen L, Chen T, et al: Cancer type-specific modulation of mitochondrial haplogroups in breast, colorectal and thyroid cancer. BMC Cancer. 10:4212010. View Article : Google Scholar : PubMed/NCBI
17	Pezzotti A, Kraft P, Hankinson SE, et al: The mitochondrial A10398G polymorphism, interaction with alcohol consumption, and breast cancer risk. PLoS One. 4:e53562009. View Article : Google Scholar : PubMed/NCBI
18	Setiawan VW, Chu LH, John EM, et al: Mitochondrial DNA G10398A variant is not associated with breast cancer in African-American women. Cancer Genet Cytogenet. 181:16–19. 2008. View Article : Google Scholar : PubMed/NCBI
19	Brandon M, Baldi P and Wallace DC: Mitochondrial mutations in cancer. Oncogene. 25:4647–4662. 2006. View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

The A10389G polymorphism of ND3 gene and breast cancer: A meta-analysis

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Related Articles