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Article

The cytotoxicity of mercury chloride to the keratinocytes is associated with metallothionein expression

  • Authors:
    • Tsann‑Long Hwang
    • Hsiao‑Ying Chen
    • Tzu‑Tsung Changchien
    • Chee‑Chan Wang
    • Chi‑Ming Wu
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Tao‑Yuan, Taiwan, R.O.C., Department of Cosmetic Science, Vanung University, Tao‑Yuan, Taiwan, R.O.C.
  • Pages: 379-382
    |
    Published online on: February 14, 2013
       https://doi.org/10.3892/br.2013.65
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Abstract

There are trace amounts of heavy metals in cosmetics. Heavy metals such as mercury (Hg), which is added to skin‑whitening cosmetics, may cause acute or chronic damage to human cells. The aim of this study was to investigate the cytotoxicity of mercury chloride (HgCl2) to human keratinocytes. the keratinocytes were treated with various concentrations of HgCl2 and the cell survival fractions were found to be 38.08, 17.59, 12.76, 3.29 and 0.77% when the cells were treated with 0.25, 0.5, 0.75, 1 and 1.5 µM of HgCl2, respectively. Moreover, we observed that the greatest damage was to the cell membrane. the metallothionein (MT) protein expression was also investigated. MT expression levels increased with increasing concentrations of HgCl2. The results indicated that MT protects the keratinocytes against HgCl2-induced toxicity.
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Copy and paste a formatted citation
Spandidos Publications style
Hwang TL, Chen HY, Changchien TT, Wang CC and Wu CM: The cytotoxicity of mercury chloride to the keratinocytes is associated with metallothionein expression. Biomed Rep 1: 379-382, 2013.
APA
Hwang, T., Chen, H., Changchien, T., Wang, C., & Wu, C. (2013). The cytotoxicity of mercury chloride to the keratinocytes is associated with metallothionein expression. Biomedical Reports, 1, 379-382. https://doi.org/10.3892/br.2013.65
MLA
Hwang, T., Chen, H., Changchien, T., Wang, C., Wu, C."The cytotoxicity of mercury chloride to the keratinocytes is associated with metallothionein expression". Biomedical Reports 1.3 (2013): 379-382.
Chicago
Hwang, T., Chen, H., Changchien, T., Wang, C., Wu, C."The cytotoxicity of mercury chloride to the keratinocytes is associated with metallothionein expression". Biomedical Reports 1, no. 3 (2013): 379-382. https://doi.org/10.3892/br.2013.65
Copy and paste a formatted citation
x
Spandidos Publications style
Hwang TL, Chen HY, Changchien TT, Wang CC and Wu CM: The cytotoxicity of mercury chloride to the keratinocytes is associated with metallothionein expression. Biomed Rep 1: 379-382, 2013.
APA
Hwang, T., Chen, H., Changchien, T., Wang, C., & Wu, C. (2013). The cytotoxicity of mercury chloride to the keratinocytes is associated with metallothionein expression. Biomedical Reports, 1, 379-382. https://doi.org/10.3892/br.2013.65
MLA
Hwang, T., Chen, H., Changchien, T., Wang, C., Wu, C."The cytotoxicity of mercury chloride to the keratinocytes is associated with metallothionein expression". Biomedical Reports 1.3 (2013): 379-382.
Chicago
Hwang, T., Chen, H., Changchien, T., Wang, C., Wu, C."The cytotoxicity of mercury chloride to the keratinocytes is associated with metallothionein expression". Biomedical Reports 1, no. 3 (2013): 379-382. https://doi.org/10.3892/br.2013.65
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