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Review

The paradox of IL‑10‑mediated modulation in cervical cancer (Review)

  • Authors:
    • Yan Wang
    • Xiao‑Hong Liu
    • Yue‑Hong Li
    • Ou Li
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology and Obstetrics, Affiliated Hospital of Hebei United University, Tangshan, Hebei 063000, P.R. China, Department of Pharmacy, Tangshan Gongren Hospital, Tangshan, Hebei 063000, P.R. China, Department of Gynaecology and Obstetrics, Tangshan Gongren Hospital, Tangshan, Hebei 063000, P.R. China
  • Pages: 347-351
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    Published online on: February 26, 2013
       https://doi.org/10.3892/br.2013.69
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Abstract

Interleukin-10 (IL-10) has opposing effects as an anti-inflammatory (potentially cancer-promoting) and antiangiogenic (potentially cancer-inhibiting) agent. The role of IL-10 in cervical cancer is also dual. Here, we review the IL-10‑mediated tumor-promoting effect and tumor-inhibiting effects in cervical cancer, among which, human papilloma virus (HPV), human leukocyte antigen-G (HLA-G) and IL-10 polymorphisms are associated with the development of cervical cancer. IL-10 is also used for the therapy of cervical cancer through enhancing proliferation, expression of immunologically important surface molecules and increasing Th1 cytokine production and cytotoxic potential in HPV-specific CD8 (+) cytotoxic T lymphocytes.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Liu XH, Li YH and Li O: The paradox of IL‑10‑mediated modulation in cervical cancer (Review). Biomed Rep 1: 347-351, 2013.
APA
Wang, Y., Liu, X., Li, Y., & Li, O. (2013). The paradox of IL‑10‑mediated modulation in cervical cancer (Review). Biomedical Reports, 1, 347-351. https://doi.org/10.3892/br.2013.69
MLA
Wang, Y., Liu, X., Li, Y., Li, O."The paradox of IL‑10‑mediated modulation in cervical cancer (Review)". Biomedical Reports 1.3 (2013): 347-351.
Chicago
Wang, Y., Liu, X., Li, Y., Li, O."The paradox of IL‑10‑mediated modulation in cervical cancer (Review)". Biomedical Reports 1, no. 3 (2013): 347-351. https://doi.org/10.3892/br.2013.69
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Liu XH, Li YH and Li O: The paradox of IL‑10‑mediated modulation in cervical cancer (Review). Biomed Rep 1: 347-351, 2013.
APA
Wang, Y., Liu, X., Li, Y., & Li, O. (2013). The paradox of IL‑10‑mediated modulation in cervical cancer (Review). Biomedical Reports, 1, 347-351. https://doi.org/10.3892/br.2013.69
MLA
Wang, Y., Liu, X., Li, Y., Li, O."The paradox of IL‑10‑mediated modulation in cervical cancer (Review)". Biomedical Reports 1.3 (2013): 347-351.
Chicago
Wang, Y., Liu, X., Li, Y., Li, O."The paradox of IL‑10‑mediated modulation in cervical cancer (Review)". Biomedical Reports 1, no. 3 (2013): 347-351. https://doi.org/10.3892/br.2013.69
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